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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Phosphoribosyl isomerase A (priA)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain (EC:4.2.1.20)
Gene namesi
Name:trpB
Ordered Locus Names:ML1272
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Tryptophan synthase beta chainPRO_0000098968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi272631.ML1272.

Structurei

3D structure databases

ProteinModelPortaliQ9CC54.
SMRiQ9CC54. Positions 36-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiCOG0133. LUCA.
HOGENOMiHOG000161710.
KOiK01696.
OMAiIPEMLYP.
OrthoDBiEOG6GFGH7.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CC54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPNLSCFSV AISEPTCHDP DSGGHFGGPD GYGGRYVPEA LMAVIEEVTA
60 70 80 90 100
AYEKERVNQD FLDLLDKLQA NYAGRPSPLY EATRLSEYAG SVRIFLKRED
110 120 130 140 150
LNHTGSHKIN NVLGQTLLAQ RMGKTRVIAE TGAGQHGVAT ATACALFGLD
160 170 180 190 200
CVIYMGALDT ARQALNVARM RLLGAEVVSV ETGSRTLKDA INDAFRDWVT
210 220 230 240 250
NADNTYYCFG TASGPHPFPT MVRDLQRVIG LETRRQIQYQ AGRLPDAVTA
260 270 280 290 300
CIGGGSNAIG IFHAFLDDPG VRLVGFEAAG DGVETGRHAA TLTGGLPGAF
310 320 330 340 350
QGTFSYLLQD EDGQTIESHS IAAGLDYPGV GPEHAWLRET GRAEYQPITD
360 370 380 390 400
SEAIEAFRLL CRTEGILPAL ESAHAVAGAL KLASEIGKGA VIVVNLSGRG
410
DKDIEAAAKW FGLLGTR
Length:417
Mass (Da):44,502
Last modified:June 1, 2001 - v1
Checksum:iD45B6103B731E63A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583921 Genomic DNA. Translation: CAC31653.1.
PIRiB87068.
RefSeqiNP_301917.1. NC_002677.1.
WP_010908238.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31653; CAC31653; CAC31653.
GeneIDi910381.
KEGGimle:ML1272.
PATRICi18054794. VBIMycLep78757_2336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583921 Genomic DNA. Translation: CAC31653.1.
PIRiB87068.
RefSeqiNP_301917.1. NC_002677.1.
WP_010908238.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CC54.
SMRiQ9CC54. Positions 36-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1272.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31653; CAC31653; CAC31653.
GeneIDi910381.
KEGGimle:ML1272.
PATRICi18054794. VBIMycLep78757_2336.

Organism-specific databases

LepromaiML1272.

Phylogenomic databases

eggNOGiCOG0133. LUCA.
HOGENOMiHOG000161710.
KOiK01696.
OMAiIPEMLYP.
OrthoDBiEOG6GFGH7.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiTRPB_MYCLE
AccessioniPrimary (citable) accession number: Q9CC54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.