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Q9CC42 (UPPP_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:ML1297
ORF Names:B2126_C2_190/B2126_C3_227
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence AAA17193.1 differs from that shown. Reason: Frameshift at position 89.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151164

Regions

Transmembrane90 – 11021Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane228 – 24821Helical; Potential
Transmembrane256 – 27621Helical; Potential

Experimental info

Sequence conflict1161S → P in AAA17193. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9CC42 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 845022213C3A60B9

FASTA28230,273
        10         20         30         40         50         60 
MTAVSAMSWW QVIVLAVVQG LTEFLPVSSS GHLAIVSRIL FTGDAGASFT AVSQLGTEVA 

        70         80         90        100        110        120 
VLVYFGRDIV RILHAWCRGL TVTLHRTADY WLGWYVIIGT IPICILGLVC KDEIRSGIRP 

       130        140        150        160        170        180 
LWVVATALVA FSGVIAFAEY VGRQNRCIEQ LNWRDALVVG VAQTLALIPG VSRSGSTISA 

       190        200        210        220        230        240 
GLFLGLDREL AARFGFLLAI PAVFASGLFS IPDAFHPITE GMSATGAQLL VATVIAFVVG 

       250        260        270        280 
LVAVSWLLRF LVQHNLYWFV GYRIVVGVGV LILLAVKTVA AT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00017 Genomic DNA. Translation: AAA17200.1. Frameshift.
U00017 Genomic DNA. Translation: AAA17193.1. Frameshift.
AL583921 Genomic DNA. Translation: CAC31678.1.
PIRC87071.
S72853.
S72860.
RefSeqNP_301931.1. NC_002677.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31678; CAC31678; CAC31678.
GeneID910413.
KEGGmle:ML1297.
PATRIC18054924. VBIMycLep78757_2399.

Organism-specific databases

LepromaML1297.
CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_MYCLE
AccessionPrimary (citable) accession number: Q9CC42
Secondary accession number(s): Q49783, Q49788
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families