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Q9CC42

- UPPP_MYCLE

UniProt

Q9CC42 - UPPP_MYCLE

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, bacA, upk, ML1297, B2126_C2_190/B2126_C3_227
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:ML1297
ORF Names:B2126_C2_190/B2126_C3_227
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1297.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei121 – 14121Helical; Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Transmembranei194 – 21421Helical; Reviewed predictionAdd
BLAST
Transmembranei228 – 24821Helical; Reviewed predictionAdd
BLAST
Transmembranei256 – 27621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Undecaprenyl-diphosphataseUniRule annotationPRO_0000151164Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1297.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CC42-1 [UniParc]FASTAAdd to Basket

« Hide

MTAVSAMSWW QVIVLAVVQG LTEFLPVSSS GHLAIVSRIL FTGDAGASFT    50
AVSQLGTEVA VLVYFGRDIV RILHAWCRGL TVTLHRTADY WLGWYVIIGT 100
IPICILGLVC KDEIRSGIRP LWVVATALVA FSGVIAFAEY VGRQNRCIEQ 150
LNWRDALVVG VAQTLALIPG VSRSGSTISA GLFLGLDREL AARFGFLLAI 200
PAVFASGLFS IPDAFHPITE GMSATGAQLL VATVIAFVVG LVAVSWLLRF 250
LVQHNLYWFV GYRIVVGVGV LILLAVKTVA AT 282
Length:282
Mass (Da):30,273
Last modified:June 1, 2001 - v1
Checksum:i845022213C3A60B9
GO

Sequence cautioni

The sequence AAA17193.1 differs from that shown. Reason: Frameshift at position 89.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161S → P in AAA17193. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00017 Genomic DNA. Translation: AAA17200.1. Frameshift.
U00017 Genomic DNA. Translation: AAA17193.1. Frameshift.
AL583921 Genomic DNA. Translation: CAC31678.1.
PIRiC87071.
S72853.
S72860.
RefSeqiNP_301931.1. NC_002677.1.
WP_010908252.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31678; CAC31678; CAC31678.
GeneIDi910413.
KEGGimle:ML1297.
PATRICi18054924. VBIMycLep78757_2399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00017 Genomic DNA. Translation: AAA17200.1 . Frameshift.
U00017 Genomic DNA. Translation: AAA17193.1 . Frameshift.
AL583921 Genomic DNA. Translation: CAC31678.1 .
PIRi C87071.
S72853.
S72860.
RefSeqi NP_301931.1. NC_002677.1.
WP_010908252.1. NC_002677.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31678 ; CAC31678 ; CAC31678 .
GeneIDi 910413.
KEGGi mle:ML1297.
PATRICi 18054924. VBIMycLep78757_2399.

Organism-specific databases

Lepromai ML1297.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiUPPP_MYCLE
AccessioniPrimary (citable) accession number: Q9CC42
Secondary accession number(s): Q49783, Q49788
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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