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Q9CC42

- UPPP_MYCLE

UniProt

Q9CC42 - UPPP_MYCLE

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:ML1297
    ORF Names:B2126_C2_190/B2126_C3_227
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1297.

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Undecaprenyl-diphosphatasePRO_0000151164Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML1297.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei90 – 11021HelicalUniRule annotationAdd
    BLAST
    Transmembranei121 – 14121HelicalUniRule annotationAdd
    BLAST
    Transmembranei165 – 18521HelicalUniRule annotationAdd
    BLAST
    Transmembranei194 – 21421HelicalUniRule annotationAdd
    BLAST
    Transmembranei228 – 24821HelicalUniRule annotationAdd
    BLAST
    Transmembranei256 – 27621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CC42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVSAMSWW QVIVLAVVQG LTEFLPVSSS GHLAIVSRIL FTGDAGASFT    50
    AVSQLGTEVA VLVYFGRDIV RILHAWCRGL TVTLHRTADY WLGWYVIIGT 100
    IPICILGLVC KDEIRSGIRP LWVVATALVA FSGVIAFAEY VGRQNRCIEQ 150
    LNWRDALVVG VAQTLALIPG VSRSGSTISA GLFLGLDREL AARFGFLLAI 200
    PAVFASGLFS IPDAFHPITE GMSATGAQLL VATVIAFVVG LVAVSWLLRF 250
    LVQHNLYWFV GYRIVVGVGV LILLAVKTVA AT 282
    Length:282
    Mass (Da):30,273
    Last modified:June 1, 2001 - v1
    Checksum:i845022213C3A60B9
    GO

    Sequence cautioni

    The sequence AAA17193.1 differs from that shown. Reason: Frameshift at position 89.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161S → P in AAA17193. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00017 Genomic DNA. Translation: AAA17200.1. Frameshift.
    U00017 Genomic DNA. Translation: AAA17193.1. Frameshift.
    AL583921 Genomic DNA. Translation: CAC31678.1.
    PIRiC87071.
    S72853.
    S72860.
    RefSeqiNP_301931.1. NC_002677.1.
    WP_010908252.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31678; CAC31678; CAC31678.
    GeneIDi910413.
    KEGGimle:ML1297.
    PATRICi18054924. VBIMycLep78757_2399.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00017 Genomic DNA. Translation: AAA17200.1 . Frameshift.
    U00017 Genomic DNA. Translation: AAA17193.1 . Frameshift.
    AL583921 Genomic DNA. Translation: CAC31678.1 .
    PIRi C87071.
    S72853.
    S72860.
    RefSeqi NP_301931.1. NC_002677.1.
    WP_010908252.1. NC_002677.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31678 ; CAC31678 ; CAC31678 .
    GeneIDi 910413.
    KEGGi mle:ML1297.
    PATRICi 18054924. VBIMycLep78757_2399.

    Organism-specific databases

    Lepromai ML1297.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiUPPP_MYCLE
    AccessioniPrimary (citable) accession number: Q9CC42
    Secondary accession number(s): Q49783, Q49788
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3