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Protein

N-acetyl-gamma-glutamyl-phosphate reductase

Gene

argC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductaseUniRule annotation (EC:1.2.1.38UniRule annotation)
Short name:
AGPRUniRule annotation
Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenaseUniRule annotation
Short name:
NAGSA dehydrogenaseUniRule annotation
Gene namesi
Name:argCUniRule annotation
Ordered Locus Names:ML1406
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1406.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001124221 – 347N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1406.

Structurei

3D structure databases

ProteinModelPortaliQ9CC15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
HOGENOMiHOG000254904.
KOiK00145.
OMAiTFVPHLT.
OrthoDBiPOG091H0412.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiPS01224. ARGC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CC15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYAIRVAVV GASGYAGGEI LRLLLGHPAY ADDRLTIGTL TAAASSGDTL
60 70 80 90 100
GEHHPHLTPL AHRVLESTEL TVLAGHDVVF LGLPHGHSAA LAERLGPETL
110 120 130 140 150
IIDCGADFRL TDAGAWGRFY ESPYAGSWPY GLPELPGGRE RLQKARRIAV
160 170 180 190 200
PGCYPTAILL ALLPAMAEGL IEPAVTVFAV SGISGAGRAA KTKLLGSEVI
210 220 230 240 250
GSARAYNIGG THRHTAEIIQ GLRVVTDRAV TVSFTPVLIP TSRGILAACT
260 270 280 290 300
ARTSSSLSKL RTAYEKAYQV EPFVYLMPEG QLPFTGAVIG SNAAHIAVAV
310 320 330 340
DEAAETFIAI SAIDNLVKGT AGAAVQSMNL ALGWPEAEGL SVVGVAP
Length:347
Mass (Da):36,031
Last modified:June 1, 2001 - v1
Checksum:i056619C0A58FBEE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA. Translation: CAC30357.1.
PIRiH87084.
RefSeqiNP_301999.1. NC_002677.1.
WP_010908320.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30357; CAC30357; CAC30357.
GeneIDi910545.
KEGGimle:ML1406.
PATRICi18055356. VBIMycLep78757_2611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA. Translation: CAC30357.1.
PIRiH87084.
RefSeqiNP_301999.1. NC_002677.1.
WP_010908320.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CC15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30357; CAC30357; CAC30357.
GeneIDi910545.
KEGGimle:ML1406.
PATRICi18055356. VBIMycLep78757_2611.

Organism-specific databases

LepromaiML1406.

Phylogenomic databases

eggNOGiENOG4105C0N. Bacteria.
COG0002. LUCA.
HOGENOMiHOG000254904.
KOiK00145.
OMAiTFVPHLT.
OrthoDBiPOG091H0412.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00108.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00150. ArgC_type1. 1 hit.
InterProiIPR023013. AGPR_AS.
IPR000706. AGPR_type-1.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_dimer_dom.
[Graphical view]
PfamiPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01850. argC. 1 hit.
PROSITEiPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGC_MYCLE
AccessioniPrimary (citable) accession number: Q9CC15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: October 5, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.