Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetylornithine aminotransferase

Gene

argD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.UniRule annotation

Catalytic activityi

N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationNote: Binds 1 pyridoxal phosphate per subunit.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139Pyridoxal phosphate; via carbonyl oxygenUniRule annotation1
Binding sitei142N2-acetyl-L-ornithineUniRule annotation1
Binding sitei281N2-acetyl-L-ornithineUniRule annotation1
Binding sitei282Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1547-MONOMER
UniPathwayiUPA00068; UER00109

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine aminotransferaseUniRule annotation (EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Ordered Locus Names:ML1409
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1409

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001127551 – 404Acetylornithine aminotransferaseAdd BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1409

Structurei

3D structure databases

ProteinModelPortaliQ9CC12
SMRiQ9CC12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 114Pyridoxal phosphate bindingUniRule annotation2
Regioni224 – 227Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8Y Bacteria
COG4992 LUCA
HOGENOMiHOG000020206
KOiK00821
OMAiGIATCTL
OrthoDBiPOG091H03ZS

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01107 ArgD_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004636 AcOrn/SuccOrn_fam
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00707 argD, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CC12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTQTNTAT MQQRWETVMM NNYGTPPIVL ASGNGAVVTD VDSNTYLDLL
60 70 80 90 100
GGIAVNVLGH RHPAVIEAVT HQITTLGHTS NLYATEPSIT LAEELVALLG
110 120 130 140 150
ADTQTRVFFC NSGTEANELA FKLSRLTGRT KLVAAQAAFH GRTMGSLALT
160 170 180 190 200
GQPAKQAAFE PLPGHVTHVP YGQVDALAAA VDNDTAAVFL EPIMGESGVI
210 220 230 240 250
VPPEGYLAAA RDITTRHGAL LVIDEVQTGI GRTGAFFAHQ HDSITPDVVT
260 270 280 290 300
LAKGLGGGLP IGAFLATGPA AELLTLGLHG STFGGNPVCT AAALAVLRVL
310 320 330 340 350
ATQGLVRRAE VLGDSMRIGI ESLSHPLIDQ VRGRGLLLGI VLTAPRAKDI
360 370 380 390 400
EKAARDAGFL VNATAPEVIR LAPPLIITES QIDSFITALP GILDASIAEL

GKKA
Length:404
Mass (Da):42,007
Last modified:June 1, 2001 - v1
Checksum:iA9465B243A4570B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA Translation: CAC30360.1
PIRiC87085
RefSeqiNP_302002.1, NC_002677.1
WP_010908323.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30360; CAC30360; CAC30360
GeneIDi910549
KEGGimle:ML1409
PATRICifig|272631.5.peg.2614

Similar proteinsi

Entry informationi

Entry nameiARGD_MYCLE
AccessioniPrimary (citable) accession number: Q9CC12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health