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Q9CC10 (ASSY_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:ML1412
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000148614

Regions

Nucleotide binding9 – 179ATP By similarity

Sites

Binding site881Citrulline By similarity
Binding site1181ATP; via amide nitrogen By similarity
Binding site1201Aspartate By similarity
Binding site1241Aspartate By similarity
Binding site1241Citrulline By similarity
Binding site1251Aspartate By similarity
Binding site1281Citrulline By similarity
Binding site1761Citrulline By similarity
Binding site2611Citrulline By similarity
Binding site2731Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CC10 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3AD2B1D33EE50E7F

FASTA39943,916
        10         20         30         40         50         60 
MMPERIILAY SGGLDTSVAI NWIGKETSHE VVAVVIDLGQ GGEDMEVVRQ RALDCGAVEA 

        70         80         90        100        110        120 
IVVDARDEFA EGYCLPTVLN NALYMDRYPL VSAISRPLIV KHLVAAARAH GGSIVAHGCT 

       130        140        150        160        170        180 
GKGNDQVRFE VGFASLAPDL EILAPVRDYA WTREKAIAFA EENAIPINVT KRSPFSIDQN 

       190        200        210        220        230        240 
VWGRAVETGF LEHLWHAPTK EVYSYTDDPT INWNTPDEVI VGFEHGVPVS IDGSPVSMLG 

       250        260        270        280        290        300 
AIEALNRRAG AQGVGRLDVV EDRLVGIKSR EIYEAPGAMV LITAHAELEH VTLERELGRF 

       310        320        330        340        350        360 
KRQTDRRWAE LVYDGLWYSP LKTALESFVA ATQQHVTGEV RMVLHGGHIA VNGRRSAESL 

       370        380        390 
YDFNLATYDE GDTFDQSAAR GFVYVYGLPS KLAARRDLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583922 Genomic DNA. Translation: CAC30363.1.
PIRF87085.
RefSeqNP_302005.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CC10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30363; CAC30363; CAC30363.
GeneID910554.
KEGGmle:ML1412.
PATRIC18055368. VBIMycLep78757_2617.

Organism-specific databases

LepromaML1412.
CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAIYNGYWW.
OrthoDBEOG6K9QCV.
ProtClustDBPRK00509.

Enzyme and pathway databases

UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_MYCLE
AccessionPrimary (citable) accession number: Q9CC10
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways