Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9CC09 (ARLY_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:ML1413
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_0000137791

Sequences

Sequence LengthMass (Da)Tools
Q9CC09 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 922E5D4119FB1CF6

FASTA47049,937
        10         20         30         40         50         60 
MSTNQGSLWG GRFAAGPSEA LVALSKSTHF DWVLAPYDIT ASRAHTKMLF RAGLLNEEQR 

        70         80         90        100        110        120 
DGLLAGLDNL AEDVADGSFL PLVTDEDVHA ALERGLIDRV GPDLGGRLRA GRSRNDQVAT 

       130        140        150        160        170        180 
LFRMWLRDAV RRVAAGALEV VDALANQAAE HSSTIMPGKT HLQSAQPILL AHHLLAHAHP 

       190        200        210        220        230        240 
LLRDVGRIVD FDKRAAVSPY GSGALAGSSL GLDPDAMAQD LGFPAAADNS VDATAARDFA 

       250        260        270        280        290        300 
AEAAFVFAMI AVDLSRLAED IILWSSTEFG YARLHDSWST GSSIMPQKKN PDIAELARGK 

       310        320        330        340        350        360 
SGRLIGNLAG LLATLKAQPL AYNRDLQEDK EPVFDSVAQL ELLLPAMAGL VASLTFNVER 

       370        380        390        400        410        420 
MAALAPAGYT LATDIAEWLV RQGVPFRSAH EAAGTAVRVA EGRGVGLEEL TDDELAAISA 

       430        440        450        460        470 
NLTPQVREVL TVEGSVSSRA ARGGTAPSQA AKQLTVVRAN ANQLRQLLMR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583922 Genomic DNA. Translation: CAC30364.1.
PIRG87085.
RefSeqNP_302006.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CC09.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029383; EBMYCP00000028989; EBMYCG00000029378.
GeneID910552.
GenomeReviewsGene locus ML1413 in contig AL450380_GR.
KEGGmle:ML1413.
NMPDRfig|272631.1.peg.878.
PATRIC18055370. VBIMycLep78757_2618.

Organism-specific databases

LepromaML1413.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016253.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMLEP272631:ML1413-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_MYCLE
AccessionPrimary (citable) accession number: Q9CC09
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents