Q9CC08 (CDH_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable CDP-diacylglycerol pyrophosphatase
EC=3.6.1.26

Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	ML1417

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell membrane; Single-pass membrane protein Potential HAMAP MF_00319.
Sequence similarities	Belongs to the cdh family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Probable CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198579
Regions
	Transmembrane	5 – 23	19	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CC08 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 54525B3DB4E2FBAC	FASTA	268	29,481
	10 20 30 40 50 60 MRRSIILVSV SVAIAMLTGA SIAEAEPMPP NNPSAATRDA LWKIVHDRCE LGYQHTGAYA 70 80 90 100 110 120 PCTLVDEQAG TALFKANYDP NQYLLLPLAR VTGIEDPALQ ELASPNYLYN AWAARGFVSS 130 140 150 160 170 180 RLNNSLPEPD IFLAINPKNA RTQDQLHIHI SCVSPTTAEI LKQVNWAEYV GWKPLPVTLQ 190 200 210 220 230 240 DHTYQALAVN RSTFESKSLF RDIQTKVTAD GNTMDHASVA VANIAPDQFL LLVAEGTEDQ 250 260 AIAAEELQDH NCSIAKRLTG QLDMETRR

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL583922 Genomic DNA. Translation: CAC30368.1.
PIR	C87086.
RefSeq	NP_302007.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q9CC08.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000027969; EBMYCP00000027575; EBMYCG00000027964.
GeneID	910519.
GenomeReviews	Gene locus ML1417 in contig AL450380_GR.
KEGG	mle:ML1417.
NMPDR	fig|272631.1.peg.879.
PATRIC	18055388. VBIMycLep78757_2627.
Organism-specific databases
Leproma	ML1417.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000018626.
HOGENOM	HBG565233.
OMA	DINGPLQ.
ProtClustDB	PRK05471.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1417-MONOMER.
Family and domain databases
HAMAP	MF_00319. Cdh. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase. [Graphical view]
KO	K01521.
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_MYCLE

Accession

Primary (citable) accession number: Q9CC08

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program