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Q9CBZ7 (PROA_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase
Gene names
Name:proA
Ordered Locus Names:ML1458
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409Gamma-glutamyl phosphate reductase HAMAP MF_00412
PRO_0000189751

Sequences

Sequence LengthMass (Da)Tools
Q9CBZ7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FFD60877C416DC77

FASTA40942,813
        10         20         30         40         50         60 
MRQEVHDAAR RARVAARALA VMPTVAKDHA LRAAATAVTA HTEEILAANA EDLQAARATD 

        70         80         90        100        110        120 
TLAATLDRLA LDRQRIDQIA GGLRQVAALP DPIGEVLRGY TLPNGLQLRQ QRVPLGVVGM 

       130        140        150        160        170        180 
IYEGRPNITV DAFGLAFKSG NAALLRGSSS AAKSNQALVE VLHAALVSED LPADAVQLLS 

       190        200        210        220        230        240 
AADRSTVTHL IQARGLVDVV IPRGGANLID AVVRDAQVPI IETGVGNCHV YVHQAADLEV 

       250        260        270        280        290        300 
AERILLNSKT RRPSVCNAAE TLLIDAAIAD HTMPRLVAAL QGAGVTVHGG LSGDPDKADL 

       310        320        330        340        350        360 
CREYLSMDIA VAVVDGVDAA IAHINEYGTG HTEAIVTTNM AAAQRFADGV DSATVMVNAS 

       370        380        390        400 
TAFTDGGQFG FGAEIGISTQ KLHARGPMGL SEMTSTKWIV WGDGQIRPA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583922 Genomic DNA. Translation: CAC30408.1.
PIRC87091.
RefSeqNP_302027.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CBZ7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029172; EBMYCP00000028778; EBMYCG00000029167.
GeneID909486.
GenomeReviewsGene locus ML1458 in contig AL450380_GR.
KEGGmle:ML1458.
NMPDRfig|272631.1.peg.899.
PATRIC18055582. VBIMycLep78757_2724.

Organism-specific databases

LepromaML1458.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015663.
HOGENOMHBG318080.
OMAQYPAACN.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycMLEP272631:ML1458-MONOMER.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 2 hits.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROA_MYCLE
AccessionPrimary (citable) accession number: Q9CBZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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