ID   Q9CBZ1_MYCLE            Unreviewed;       924 AA.
AC   Q9CBZ1;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=Possible ribonuclease {ECO:0000313|EMBL:CAC30418.1};
GN   OrderedLocusNames=ML1468 {ECO:0000313|EMBL:CAC30418.1};
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631 {ECO:0000313|EMBL:CAC30418.1, ECO:0000313|Proteomes:UP000000806};
RN   [1] {ECO:0000313|EMBL:CAC30418.1, ECO:0000313|Proteomes:UP000000806}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN {ECO:0000313|EMBL:CAC30418.1,
RC   ECO:0000313|Proteomes:UP000000806};
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   EMBL; AL583922; CAC30418.1; -; Genomic_DNA.
DR   PIR; E87092; E87092.
DR   RefSeq; NP_302033.1; NC_002677.1.
DR   RefSeq; WP_010908354.1; NC_002677.1.
DR   AlphaFoldDB; Q9CBZ1; -.
DR   STRING; 272631.gene:17575306; -.
DR   KEGG; mle:ML1468; -.
DR   PATRIC; fig|272631.5.peg.2744; -.
DR   Leproma; ML1468; -.
DR   eggNOG; COG1530; Bacteria.
DR   HOGENOM; CLU_003468_2_0_11; -.
DR   OrthoDB; 9804278at2; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd04453; S1_RNase_E; 1.
DR   Gene3D; 1.10.10.2480; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR   InterPro; IPR004659; RNase_E/G.
DR   InterPro; IPR003029; S1_domain.
DR   NCBIfam; TIGR00757; RNaseEG; 1.
DR   PANTHER; PTHR30001; RIBONUCLEASE; 1.
DR   PANTHER; PTHR30001:SF0; RIBONUCLEASE G; 1.
DR   Pfam; PF10150; RNase_E_G; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50126; S1; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000806};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          358..435
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   REGION          113..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          742..784
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          796..888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..142
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..205
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..298
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        826..885
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   924 AA;  101259 MW;  AE0BE876D0EE4319 CRC64;
     MIDGAPPLEP SKEPTQHMEL PDRLRVHSLA RTLGTTSRRV LDVLSALDGR IRSAHSSVDR
     VDAVRVRDLL ASQPNSPHEL TAVPDNPVAL EERDSRLVLE TTVERPHYMP LFVAPQPIEV
     DDDSCADDDV ESGDDSDVGD DEEQPDRPAN RRRRRGRRGR GRGRGEQGGS DVQSDDVDGA
     VDSTESEDFD GQDFDESEDT EIGYDESGSS EAGNRRRRRR RRRKSGVGED EGCAPDDPPN
     TVVHERTPRA AGRSASFDNG VNGTGSADIK GIDGSTRLEA KRQRRRDGRD AGRRRSSVLS
     EAEFLARRES VERVMVVRDR IRTEPPHPGA RYTQIAVLED GIVVEHFVTS AASASLVGNI
     YLGIVQNVLP SMEAAFVDIG RGRNGVLYAG EVNWEAAGLG GADRKIEQAL KPGDYIVVQV
     NKDPVGHKGA RLTTQVSLAG RYLVYVPGAS STGISRKLPD TERQRLKEIL REVVPPDAGV
     IIRTASEGVK EEDIRKDVTR LQEHWEQIEA KTIQTKEKAA GAAVALYEEP DVLVKVIRDL
     FNDDFSGLVV SGDEAWNTIN EYVNSVAPEL VSKLTKYDPP IGPDGQHGPD VFAVHRIDEQ
     LAKAMDRKVW LPSGGTLVID RTEAMTVIDV NTGKFTGSGG NLEQTVTKNN LEAAEEIVRQ
     LRLRDIGGIV VIDFIDMVLE SNRDLVLRRL TEVLARDRTR HQVSEVTSLG LVQLTRKRLG
     TGLVEAFSTS CPNCTGRGIL LHTDPANSTP MVGRKSESGG RRSKRSKKNR SDETAVVKVP
     VHAPGEHPMF KAMAAGSSSV VVGGEDESNE SGTELTGKID EPLEEQAVAG LDDVDQEDFD
     TDEEDDLDDD EELDDEEDLG DDDEELDLDD DLDVDEDESD SEADLDSADV LDRSTLLIRN
     RSGFARPRRR RAAGRPAGPP IHVD
//