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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13ZincUniRule annotation1
Metal bindingi16ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:ML1495
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001981 – 3081D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1495.

Structurei

3D structure databases

ProteinModelPortaliQ9CBX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CBX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETPRLLFV HAHPDDESLS NGATIAHYTS RGAQVQVVTC TLGEEGEVIG
60 70 80 90 100
DRWAELTVDH ADQLGGYRIF ELTEALRALG VSAPIYLGGA GRWRDSGMRG
110 120 130 140 150
TAPRRRQRFI DADENEAVGA LVAIIRELRP HVVVTYDPHG GYGHPDHVHT
160 170 180 190 200
HFITAAAVAS SGVAAGLEVG ADEYPGKPWK VPKFYWSVFA LSAFEAGMNA
210 220 230 240 250
LQGKDLRPEW TIPPREEFYF GYSDKDIDAV VEATSDVWAA KTAALTAHAT
260 270 280 290 300
QVVVGPTGRA CALSNNMVMP IFAQEHYVLA AGSAGNRDER GWETDLLAGL

CLDGFDAR
Length:308
Mass (Da):33,345
Last modified:June 1, 2001 - v1
Checksum:i60D061D5FCDCFCA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA. Translation: CAC30445.1.
PIRiH87095.
RefSeqiNP_302050.1. NC_002677.1.
WP_010908371.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30445; CAC30445; CAC30445.
GeneIDi909527.
KEGGimle:ML1495.
PATRICi18055750. VBIMycLep78757_2806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA. Translation: CAC30445.1.
PIRiH87095.
RefSeqiNP_302050.1. NC_002677.1.
WP_010908371.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CBX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1495.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30445; CAC30445; CAC30445.
GeneIDi909527.
KEGGimle:ML1495.
PATRICi18055750. VBIMycLep78757_2806.

Organism-specific databases

LepromaiML1495.

Phylogenomic databases

eggNOGiENOG4108KZ5. Bacteria.
COG2120. LUCA.
HOGENOMiHOG000241173.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHB_MYCLE
AccessioniPrimary (citable) accession number: Q9CBX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 1, 2001
Last modified: October 5, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.