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Q9CBW1 (DYR_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrofolate reductase

EC=1.5.1.3
Gene names
Name:folA
Ordered Locus Names:ML1518
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Dihydrofolate reductase
PRO_0000186399

Regions

Domain3 – 165163DHFR
Nucleotide binding8 – 92NADP By similarity
Nucleotide binding16 – 216NADP By similarity
Nucleotide binding45 – 484NADP By similarity
Nucleotide binding67 – 704NADP By similarity
Nucleotide binding100 – 1056NADP By similarity
Region7 – 93Substrate binding By similarity

Sites

Binding site291Substrate By similarity
Binding site621Substrate By similarity
Binding site1191Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CBW1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E6A76965BFBEC74F

FASTA16518,509
        10         20         30         40         50         60 
MTVVGLIWAQ STTGVIGRDG GMPWRVPEDL TRFKQLTMGH PVVMGRRTWD SLPVGVRPLP 

        70         80         90        100        110        120 
GRRNIVLSRQ IDFMAEGAEV FGSLEETISN LETEPEMWVI GGEQIYRLAL PLATRCGVTE 

       130        140        150        160 
VDTYLLHEDD DVLAPVLDDT WVGVTGEWLV SCSGLRYRLH SYHRS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583922 Genomic DNA. Translation: CAC30469.1.
PIRH87098.
RefSeqNP_302063.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CBW1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1518.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30469; CAC30469; CAC30469.
GeneID909551.
KEGGmle:ML1518.
PATRIC18055860. VBIMycLep78757_2861.

Organism-specific databases

LepromaML1518.
CMRSearch...

Phylogenomic databases

eggNOGCOG0262.
HOGENOMHOG000040234.
KOK00287.
OMAGLRYRFH.
OrthoDBEOG6KT2V2.
ProtClustDBCLSK792062.

Enzyme and pathway databases

UniPathwayUPA00077; UER00158.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PIRSFPIRSF000194. DHFR. 1 hit.
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR_MYCLE
AccessionPrimary (citable) accession number: Q9CBW1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: November 13, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways