Q9CBU7 (Q9CBU7_MYCLE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methionine aminopeptidase RuleBase RU003653
EC=3.4.11.18 RuleBase RU003653

Gene names

Name:	mapB EMBL CAC30527.1
Ordered Locus Names:	ML1576

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the N-terminal methionine from nascent proteins By similarity. RuleBase RU003653
Catalytic activity	Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. RuleBase RU003653
Cofactor	Binds 2 cobalt ions per subunit By similarity. RuleBase RU003653
Sequence similarities	Belongs to the peptidase M24A family. RuleBase RU003653

Ontologies

Keywords
Ligand	Cobalt RuleBase RU003653 Metal-binding RuleBase RU003653
Molecular function	Aminopeptidase RuleBase RU003653 EMBL CAC30527.1 Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9CBU7 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 0A4CB81646BE4BF5	FASTA	285	31,126
	10 20 30 40 50 60 MPARTALSPG FLSPTLPVPA WIPRPEYVGK PTAQEGSESW VQTPEVVEKM RVAGRIAAGA 70 80 90 100 110 120 LTEAGKAVAP GVTTDELDRI VHEYMVNHGA YPSTLGYKGY PKSCCTSLNE VICHGIPDST 130 140 150 160 170 180 VIADGDIVNI DVTAYIDGVH GDTNATFLSG DVSESHRLLV ERTREATMRA INAVKPGRAL 190 200 210 220 230 240 SIIGRVIESY ANRFGYNVVR HFTGHGIGTT FHNGLVVLHY DQPFVTTIMQ PGMTFTIEPM 250 260 270 280 INLGTLDYEV WDDGWTVVTK DRKWTAQFEH TLLVTDTGVE ILTVQ

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL583922 Genomic DNA. Translation: CAC30527.1.
PIR	B87106.
RefSeq	NP_302090.1. NC_002677.1.
3D structure databases
HSSP	HSSP built from PDB template 1C24 based on UniProtKB P07906.
ProteinModelPortal	Q9CBU7.
SMR	Q9CBU7. Positions 4-283.
ModBase	Search...
Protein family/group databases
MEROPS	M24.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029495; EBMYCP00000029101; EBMYCG00000029490.
GeneID	909624.
GenomeReviews	Gene locus ML1576 in contig AL450380_GR.
KEGG	mle:ML1576.
NMPDR	fig|272631.1.peg.962.
PATRIC	18056092. VBIMycLep78757_2978.
Organism-specific databases
Leproma	ML1576.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016752.
HOGENOM	HBG299384.
OMA	IEPMISE.
ProtClustDB	PRK12896.
Family and domain databases
InterPro	IPR001714. Pept_M24_MAP. IPR000994. Pept_M24_structural-domain. IPR002467. Pept_M24A_MAP1. [Graphical view]
Gene3D	G3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
KO	K01265.
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
PRINTS	PR00599. MAPEPTIDASE.
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
TIGRFAMs	TIGR00500. Met_pdase_I. 1 hit.
PROSITE	PS00680. MAP_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9CBU7_MYCLE

Accession

Primary (citable) accession number: Q9CBU7

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)