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Q9CBU3 (DXR_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Short name=DXP reductoisomerase
EC=1.1.1.267
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name:dxr
Ordered Locus Names:ML1583
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183

Cofactor

Divalent cation By similarity. HAMAP MF_00183

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183

Sequence similarities

Belongs to the DXR family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   LigandMetal-binding
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity

Inferred from electronic annotation. Source: EC

NADPH binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4064061-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
PRO_0000163676

Regions

Nucleotide binding18 – 4730NADP By similarity

Sites

Metal binding1511Divalent metal cation By similarity
Metal binding1531Divalent metal cation By similarity
Metal binding2221Divalent metal cation By similarity
Binding site1281Substrate By similarity
Binding site1531Substrate By similarity
Binding site1771Substrate By similarity
Binding site2001Substrate By similarity
Binding site2221Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CBU3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: B5213228251666FD

FASTA40642,315
        10         20         30         40         50         60 
MNNPIEGHAG GRLRVLVLGS TGSIGTQALE VIAANPDRFE VVGLAAGGAQ LDTLLRQRAA 

        70         80         90        100        110        120 
TGVTNIAIAD DRAAQLAGDI PYHGTDAVTR LVEETEADVV LNALVGALGL RPTLAALHTG 

       130        140        150        160        170        180 
ARLALANKES LVAGGSLVLA AAQPGQIVPV DSEHSALAQC LRGGTPDEVA KLVLTASGGP 

       190        200        210        220        230        240 
FRGWNAGDLE RVTPEQAGVH PTWSMGTMNT LNSASLVNKG LELIEANLLF GIPYDRIEVV 

       250        260        270        280        290        300 
VHPQSIVHSM VTFIDGSTIA QASPPDMKLP ISLALGWPQR VGGAARACAF TTASTWEFEP 

       310        320        330        340        350        360 
LDIDVFPAVE LARHAGQIGG CMTAIYDAAN EEAAEAFLQG RIGFPAIVAT IADVLQRADQ 

       370        380        390        400 
WAPQWGEGPA TVDDVLDAQR WARERALCAV ATASSGKVSD MVLERS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583922 Genomic DNA. Translation: CAC30534.1.
PIRA87107.
RefSeqNP_302094.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CBU3.
SMRQ9CBU3. Positions 11-391.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028611; EBMYCP00000028217; EBMYCG00000028606.
GeneID909644.
GenomeReviewsGene locus ML1583 in contig AL450380_GR.
KEGGmle:ML1583.
NMPDRfig|272631.1.peg.966.
PATRIC18056104. VBIMycLep78757_2984.

Organism-specific databases

LepromaML1583.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016490.
HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycMLEP272631:ML1583-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDXR_MYCLE
AccessionPrimary (citable) accession number: Q9CBU3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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