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Q9CBU1 (CDSA_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase

EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene names
Name:cdsA
Ordered Locus Names:ML1589
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the CDS family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphatidate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Phosphatidate cytidylyltransferase
PRO_0000090742

Regions

Transmembrane37 – 5721Helical; Potential
Transmembrane58 – 7821Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane157 – 17721Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane247 – 26721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CBU1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 5A1C1DEFDD3E4913

FASTA31232,972
        10         20         30         40         50         60 
MASTDPGTGT PLDESVPGIK RAMRQSTKNT PRAGRNLPAA IAVGLSIGGV LVATLVFAPR 

        70         80         90        100        110        120 
IWVVLCAGAI FVASHEVVRR LREAGYVIPA IPLLIGGQFT VWLTWPYRTV GALAGFGATV 

       130        140        150        160        170        180 
VVCMIWRLVM HDNSKQHESR EALAGPPVSN YLRDASATVF LAAWVPLFAS FAALLVYPKD 

       190        200        210        220        230        240 
GAGRVFCLMI AVVASDVGGY TVGVLFGKHP LVPRISPNKS WEGFAGSLVC GTTATILTAT 

       250        260        270        280        290        300 
FLAGKTPWVG ALLSFVLVLT CTLGDLVESQ VKRDLGIKDM GRLLPGHGGL MDRLDGVLPS 

       310 
AVVAWTMLTL LP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583922 Genomic DNA. Translation: CAC30540.1.
PIRG87107.
RefSeqNP_302096.1. NC_002677.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028010; EBMYCP00000027616; EBMYCG00000028005.
GeneID909784.
GenomeReviewsGene locus ML1589 in contig AL450380_GR.
KEGGmle:ML1589.
NMPDRfig|272631.1.peg.968.
PATRIC18056130. VBIMycLep78757_2997.

Organism-specific databases

LepromaML1589.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017496.
HOGENOMHBG732679.
OMAFGSHPMA.
ProtClustDBCLSK792142.

Enzyme and pathway databases

BioCycMLEP272631:ML1589-MONOMER.

Family and domain databases

InterProIPR000374. PC_trans.
[Graphical view]
KOK00981.
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDSA_MYCLE
AccessionPrimary (citable) accession number: Q9CBU1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families