Reviewed, UniProtKB/Swiss-Prot Q9CBU1 (CDSA_MYCLE)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	ML1589

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Phosphatidate cytidylyltransferase		PRO_0000090742
Regions
	Transmembrane	37 – 57	21	Potential
	Transmembrane	58 – 78	21	Potential
	Transmembrane	85 – 105	21	Potential
	Transmembrane	110 – 130	21	Potential
	Transmembrane	157 – 177	21	Potential
	Transmembrane	186 – 206	21	Potential
	Transmembrane	223 – 243	21	Potential
	Transmembrane	247 – 267	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CBU1-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5A1C1DEFDD3E4913	FASTA	312	32,972
	10 20 30 40 50 60 MASTDPGTGT PLDESVPGIK RAMRQSTKNT PRAGRNLPAA IAVGLSIGGV LVATLVFAPR 70 80 90 100 110 120 IWVVLCAGAI FVASHEVVRR LREAGYVIPA IPLLIGGQFT VWLTWPYRTV GALAGFGATV 130 140 150 160 170 180 VVCMIWRLVM HDNSKQHESR EALAGPPVSN YLRDASATVF LAAWVPLFAS FAALLVYPKD 190 200 210 220 230 240 GAGRVFCLMI AVVASDVGGY TVGVLFGKHP LVPRISPNKS WEGFAGSLVC GTTATILTAT 250 260 270 280 290 300 FLAGKTPWVG ALLSFVLVLT CTLGDLVESQ VKRDLGIKDM GRLLPGHGGL MDRLDGVLPS 310 AVVAWTMLTL LP

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL583922 Genomic DNA. Translation: CAC30540.1.
PIR	G87107.
RefSeq	NP_302096.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	909784.
KEGG	mle:ML1589.
NMPDR	fig|272631.1.peg.968.
Organism-specific databases
Leproma	ML1589.
CMR	Search...
Phylogenomic databases
HOGENOM	HBG732679.
OMA	FGKHPMA.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1589-MONOMER.
BRENDA	2.7.7.41. 808.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_MYCLE

Accession

Primary (citable) accession number: Q9CBU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)