Reviewed,
UniProtKB/Swiss-Prot Q9CBU1 (CDSA_MYCLE)
Last modified
February 9, 2010.
Version 54.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphatidate cytidylyltransferase EC=2.7.7.41 Alternative name(s): CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CDP-diacylglycerol synthase Short name=CDS CTP:phosphatidate cytidylyltransferase CDP-DG synthase CDP-DAG synthase | ||||
| Gene names |
| ||||
| Organism | Mycobacterium leprae [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1769 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 312 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
| Pathway | |
| Subcellular location | Cell membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the CDS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phospholipid biosynthesis |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 312 | 312 | Phosphatidate cytidylyltransferase | PRO_0000090742 | |||||
Regions | |||||||||
| Transmembrane | 37 – 57 | 21 | Potential | ||||||
| Transmembrane | 58 – 78 | 21 | Potential | ||||||
| Transmembrane | 85 – 105 | 21 | Potential | ||||||
| Transmembrane | 110 – 130 | 21 | Potential | ||||||
| Transmembrane | 157 – 177 | 21 | Potential | ||||||
| Transmembrane | 186 – 206 | 21 | Potential | ||||||
| Transmembrane | 223 – 243 | 21 | Potential | ||||||
| Transmembrane | 247 – 267 | 21 | Potential | ||||||
Sequences
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References
| [1] | "Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G.Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL583922 Genomic DNA. Translation: CAC30540.1. |
| PIR | G87107. |
| RefSeq | NP_302096.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 909784. |
| KEGG | mle:ML1589. |
| NMPDR | fig|272631.1.peg.968. |
Organism-specific databases | |
| Leproma | ML1589. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG732679. |
| OMA | FGKHPMA. |
Enzyme and pathway databases | |
| BioCyc | MLEP272631:ML1589-MONOMER. |
| BRENDA | 2.7.7.41. 808. |
Family and domain databases | |
| InterPro | IPR000374. PC_trans. [Graphical view] |
| Pfam | PF01148. CTP_transf_1. 1 hit. [Graphical view] |
| PROSITE | PS01315. CDS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDSA_MYCLE | ||||||||
| Accession | Primary (citable) accession number: Q9CBU1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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