Q9CBU1 (CDSA_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	ML1589

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Phosphatidate cytidylyltransferase		PRO_0000090742
Regions
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	58 – 78	21	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	157 – 177	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	223 – 243	21	Helical; Potential
	Transmembrane	247 – 267	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CBU1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 5A1C1DEFDD3E4913	FASTA	312	32,972
	10 20 30 40 50 60 MASTDPGTGT PLDESVPGIK RAMRQSTKNT PRAGRNLPAA IAVGLSIGGV LVATLVFAPR 70 80 90 100 110 120 IWVVLCAGAI FVASHEVVRR LREAGYVIPA IPLLIGGQFT VWLTWPYRTV GALAGFGATV 130 140 150 160 170 180 VVCMIWRLVM HDNSKQHESR EALAGPPVSN YLRDASATVF LAAWVPLFAS FAALLVYPKD 190 200 210 220 230 240 GAGRVFCLMI AVVASDVGGY TVGVLFGKHP LVPRISPNKS WEGFAGSLVC GTTATILTAT 250 260 270 280 290 300 FLAGKTPWVG ALLSFVLVLT CTLGDLVESQ VKRDLGIKDM GRLLPGHGGL MDRLDGVLPS 310 AVVAWTMLTL LP

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL583922 Genomic DNA. Translation: CAC30540.1.
PIR	G87107.
RefSeq	NP_302096.1. NC_002677.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000028010; EBMYCP00000027616; EBMYCG00000028005.
GeneID	909784.
GenomeReviews	Gene locus ML1589 in contig AL450380_GR.
KEGG	mle:ML1589.
NMPDR	fig|272631.1.peg.968.
PATRIC	18056130. VBIMycLep78757_2997.
Organism-specific databases
Leproma	ML1589.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017496.
HOGENOM	HBG732679.
OMA	FGSHPMA.
ProtClustDB	CLSK792142.
Enzyme and pathway databases
BioCyc	MLEP272631:ML1589-MONOMER.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_MYCLE

Accession

Primary (citable) accession number: Q9CBU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program