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Protein

Chromosome partition protein Smc

Gene

smc

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for chromosome condensation and partitioning.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein SmcUniRule annotation
Gene namesi
Name:smcUniRule annotation
Ordered Locus Names:ML1629
ORF Names:MLCB250.01
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1629.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12031203Chromosome partition protein SmcPRO_0000119029Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1629.

Structurei

3D structure databases

ProteinModelPortaliQ9CBT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili167 – 20337UniRule annotationAdd
BLAST
Coiled coili250 – 28839UniRule annotationAdd
BLAST
Coiled coili327 – 497171UniRule annotationAdd
BLAST
Coiled coili657 – 68933UniRule annotationAdd
BLAST
Coiled coili720 – 76546UniRule annotationAdd
BLAST
Coiled coili976 – 103055UniRule annotationAdd
BLAST

Domaini

Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.UniRule annotation

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105CDB. Bacteria.
COG1196. LUCA.
HOGENOMiHOG000036389.
KOiK03529.
OMAiAFQTASN.
OrthoDBiEOG6WQD34.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01894. Smc_prok.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
IPR011890. SMC_prok.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
TIGRFAMsiTIGR02168. SMC_prok_B. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CBT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLKSLTLKG FKSFASPTTL RFEPGITAVV GPNGSGKSNV VDALAWVMGE
60 70 80 90 100
QGAKTLRGSK MEDVIFAGTL SRAPLGRAEV TLIIDNSDNV LPIEYSEVSI
110 120 130 140 150
TRRMFRDGAS EYEINGSSCR LMDVQELLSD SGIGREMHVI VGQGKLDQIL
160 170 180 190 200
QSRPEDRRTF IEEAAGILKY RRRKEKALRK LDAMSANLAR LTDLTTELRR
210 220 230 240 250
QLKPLSRQAE VARRAATIQA DLRDARLRLA ADDLVSRQGQ RDAIVEAETM
260 270 280 290 300
MRRDHDEAAA RLAVASEELA AHEAALTELS GRAESVQQIW FGLSTLVERV
310 320 330 340 350
SATIRIAGER AYHLDVDPAT PSDTDPDVLE AEAQQMEVAE QQLLAELAVA
360 370 380 390 400
RTQLEAARAE LADRERHAVE ADKAHLEAVR AEADRREGLA LLAGQVETMR
410 420 430 440 450
ARIESIDDSV ARLSERIEEV TARTQQILAE FETVQGRVGE LDQSEVHLDE
460 470 480 490 500
QHERAVAALR FANERVAELQ SAERDAERQV VSLRARIDAL TMGLERKDGA
510 520 530 540 550
AWLARNYSDT GLLGSIAKLV KVRPGYEAAL AAVLGPAADA LAVDSLGAAR
560 570 580 590 600
SALTALKEAD AGRATLVLAD WLADAGPACV TGLPDGAQRA LDLIEAPPWL
610 620 630 640 650
QGALIAMLYG VVVVNYLAEA LGVVDICPQL RVVTVDGDLV GAGWVSGGSG
660 670 680 690 700
RRLSTLEVTS EIDKAGAELA AAEAHMAQLN AALSGALSEQ VAHSDATEQA
710 720 730 740 750
LVALNESDTA ILSMYDQLGR LGQEVRAAEA EWESLLAQRE ELEARRVSIL
760 770 780 790 800
EEVVELETRL HNVEQIQHVH ALDENSAAAR QLIVAAAEEA RGVEVEALLA
810 820 830 840 850
VRTAEERVNA VCGRANSLRR AAAAEREVRL RDQQAHAARI RAAAVAAAVT
860 870 880 890 900
DCGQLLASRL TQAVDLAARH RDALATERQQ RSVAIAAVRY EVNTLRVRLA
910 920 930 940 950
TLTDSLHRDE VANVQAALRI EQLEQLVLEQ FGIAPVDLIA EYGPQVALLP
960 970 980 990 1000
TELEMAEFQQ ARERGEQVTS PAPMPYDRAT QERRAKRAER ELAELGRVNP
1010 1020 1030 1040 1050
LALEEFAALE ERYNFLSTQL EDVKGARKDL LDVVAEVDAR ILQVFSDAFV
1060 1070 1080 1090 1100
DVEREFRGVF TSLFPGGEGR LRLTDPDDML TTGIEVEARP SGKKVSRLSL
1110 1120 1130 1140 1150
LSGGEKSLIA VAMLVAIFKA RPSPFYIMDE VEAALDDVNL CRLIGVFEQL
1160 1170 1180 1190 1200
RGQSQLIIIT HQKPTMEVAD TLYGVTMQGD GITAVISQRM RGQQVESLVT

SSS
Length:1,203
Mass (Da):131,027
Last modified:June 1, 2001 - v1
Checksum:iA0B0FB6E41B4075A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA. Translation: CAC30580.1.
Z97369 Genomic DNA. Translation: CAB10595.1.
PIRiG87112.
RefSeqiNP_302121.1. NC_002677.1.
WP_010908442.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30580; CAC30580; CAC30580.
GeneIDi909835.
KEGGimle:ML1629.
PATRICi18056276. VBIMycLep78757_3070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA. Translation: CAC30580.1.
Z97369 Genomic DNA. Translation: CAB10595.1.
PIRiG87112.
RefSeqiNP_302121.1. NC_002677.1.
WP_010908442.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CBT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30580; CAC30580; CAC30580.
GeneIDi909835.
KEGGimle:ML1629.
PATRICi18056276. VBIMycLep78757_3070.

Organism-specific databases

LepromaiML1629.

Phylogenomic databases

eggNOGiENOG4105CDB. Bacteria.
COG1196. LUCA.
HOGENOMiHOG000036389.
KOiK03529.
OMAiAFQTASN.
OrthoDBiEOG6WQD34.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01894. Smc_prok.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
IPR011890. SMC_prok.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
TIGRFAMsiTIGR02168. SMC_prok_B. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiSMC_MYCLE
AccessioniPrimary (citable) accession number: Q9CBT5
Secondary accession number(s): Q9X7D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.