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Protein

Chromosome partition protein Smc

Gene

smc

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for chromosome condensation and partitioning.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1781-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein SmcUniRule annotation
Gene namesi
Name:smcUniRule annotation
Ordered Locus Names:ML1629
ORF Names:MLCB250.01
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1629

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190291 – 1203Chromosome partition protein SmcAdd BLAST1203

Proteomic databases

PRIDEiQ9CBT5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1629

Structurei

3D structure databases

ProteinModelPortaliQ9CBT5
SMRiQ9CBT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili167 – 203UniRule annotationAdd BLAST37
Coiled coili250 – 288UniRule annotationAdd BLAST39
Coiled coili327 – 497UniRule annotationAdd BLAST171
Coiled coili657 – 689UniRule annotationAdd BLAST33
Coiled coili720 – 765UniRule annotationAdd BLAST46
Coiled coili976 – 1030UniRule annotationAdd BLAST55

Domaini

Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.UniRule annotation

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105CDB Bacteria
COG1196 LUCA
HOGENOMiHOG000036389
KOiK03529
OMAiHNKIAME
OrthoDBiPOG091H026E

Family and domain databases

HAMAPiMF_01894 Smc_prok, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
IPR011890 SMC_prok
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF75553 SSF75553, 1 hit
TIGRFAMsiTIGR02168 SMC_prok_B, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CBT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLKSLTLKG FKSFASPTTL RFEPGITAVV GPNGSGKSNV VDALAWVMGE
60 70 80 90 100
QGAKTLRGSK MEDVIFAGTL SRAPLGRAEV TLIIDNSDNV LPIEYSEVSI
110 120 130 140 150
TRRMFRDGAS EYEINGSSCR LMDVQELLSD SGIGREMHVI VGQGKLDQIL
160 170 180 190 200
QSRPEDRRTF IEEAAGILKY RRRKEKALRK LDAMSANLAR LTDLTTELRR
210 220 230 240 250
QLKPLSRQAE VARRAATIQA DLRDARLRLA ADDLVSRQGQ RDAIVEAETM
260 270 280 290 300
MRRDHDEAAA RLAVASEELA AHEAALTELS GRAESVQQIW FGLSTLVERV
310 320 330 340 350
SATIRIAGER AYHLDVDPAT PSDTDPDVLE AEAQQMEVAE QQLLAELAVA
360 370 380 390 400
RTQLEAARAE LADRERHAVE ADKAHLEAVR AEADRREGLA LLAGQVETMR
410 420 430 440 450
ARIESIDDSV ARLSERIEEV TARTQQILAE FETVQGRVGE LDQSEVHLDE
460 470 480 490 500
QHERAVAALR FANERVAELQ SAERDAERQV VSLRARIDAL TMGLERKDGA
510 520 530 540 550
AWLARNYSDT GLLGSIAKLV KVRPGYEAAL AAVLGPAADA LAVDSLGAAR
560 570 580 590 600
SALTALKEAD AGRATLVLAD WLADAGPACV TGLPDGAQRA LDLIEAPPWL
610 620 630 640 650
QGALIAMLYG VVVVNYLAEA LGVVDICPQL RVVTVDGDLV GAGWVSGGSG
660 670 680 690 700
RRLSTLEVTS EIDKAGAELA AAEAHMAQLN AALSGALSEQ VAHSDATEQA
710 720 730 740 750
LVALNESDTA ILSMYDQLGR LGQEVRAAEA EWESLLAQRE ELEARRVSIL
760 770 780 790 800
EEVVELETRL HNVEQIQHVH ALDENSAAAR QLIVAAAEEA RGVEVEALLA
810 820 830 840 850
VRTAEERVNA VCGRANSLRR AAAAEREVRL RDQQAHAARI RAAAVAAAVT
860 870 880 890 900
DCGQLLASRL TQAVDLAARH RDALATERQQ RSVAIAAVRY EVNTLRVRLA
910 920 930 940 950
TLTDSLHRDE VANVQAALRI EQLEQLVLEQ FGIAPVDLIA EYGPQVALLP
960 970 980 990 1000
TELEMAEFQQ ARERGEQVTS PAPMPYDRAT QERRAKRAER ELAELGRVNP
1010 1020 1030 1040 1050
LALEEFAALE ERYNFLSTQL EDVKGARKDL LDVVAEVDAR ILQVFSDAFV
1060 1070 1080 1090 1100
DVEREFRGVF TSLFPGGEGR LRLTDPDDML TTGIEVEARP SGKKVSRLSL
1110 1120 1130 1140 1150
LSGGEKSLIA VAMLVAIFKA RPSPFYIMDE VEAALDDVNL CRLIGVFEQL
1160 1170 1180 1190 1200
RGQSQLIIIT HQKPTMEVAD TLYGVTMQGD GITAVISQRM RGQQVESLVT

SSS
Length:1,203
Mass (Da):131,027
Last modified:June 1, 2001 - v1
Checksum:iA0B0FB6E41B4075A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583922 Genomic DNA Translation: CAC30580.1
Z97369 Genomic DNA Translation: CAB10595.1
PIRiG87112
RefSeqiNP_302121.1, NC_002677.1
WP_010908442.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30580; CAC30580; CAC30580
GeneIDi909835
KEGGimle:ML1629
PATRICifig|272631.5.peg.3070

Similar proteinsi

Entry informationi

Entry nameiSMC_MYCLE
AccessioniPrimary (citable) accession number: Q9CBT5
Secondary accession number(s): Q9X7D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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