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Q9CBS8 (Q9CBS8_MYCLE) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL CAC30602.1
Ordered Locus Names:ML1651
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length936 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
Q9CBS8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 253544F17332DF17

FASTA936104,702
        10         20         30         40         50         60 
MTIEFARPDL AKNPSSTNES NSVRVIREGV ASYLPDIDPE ETAEWLESFD ELLKHSGPSR 

        70         80         90        100        110        120 
ARYLILRLLE RAGEQRVTIP ALTWTDYVNT IPTELEPWFP GDEDIERRYR TWIRWNAAIM 

       130        140        150        160        170        180 
VHRAQRPGVG VGGHISTYAS SAALYEVGFN HFFRGKSHPS GGDQVFIQGH ASPGIYARAF 

       190        200        210        220        230        240 
LEGRLSADQL DGFRQEHSHP GGGLPSYPHP RLMPDFWEFP TVSMGLGPLN AIYQARFNRY 

       250        260        270        280        290        300 
LHDRGIKDTS DQHVWCFLGD GEMDEPESRG LAHVASLEDL DNLIFVINCN LQRLDGPVRG 

       310        320        330        340        350        360 
NGKIIQELES FFRGAGWNVI KVVWGREWDA LLHADRDGAL VDLMNATPDG DYQTYKANDG 

       370        380        390        400        410        420 
RFVRDHFFGR DPRTKALVEH MSDQEIWNLK RGGHDYRKVY ASYRAAVDHK GQPTVILAKT 

       430        440        450        460        470        480 
IKGYALGKHF ESRNATHQMK KLTLEDLKEF RDTQRIPISD TELEENPYLP PYYHPGPDSP 

       490        500        510        520        530        540 
EIRYLLDRRR ALGGFLPERR TKSGALTLPG RDTYAALKTG SGQQEVATTM AIVRTFKEVL 

       550        560        570        580        590        600 
RHKEVGPRIV PIIPDEARTF GMDSWFPSLK IYNHNGQLYT AVDAQLMLAY KESEVGQILH 

       610        620        630        640        650        660 
EGIDEAGSVG SFIAAGTSYS THNEPMIPIY IFYSMFGFQR TGDGLWAAAD QMARGFLLGA 

       670        680        690        700        710        720 
TAGRTTLTGE GLQHADGHSL LLAATNPAVV TYDPAFAYEI AYIVESGLTR MFGEDPENVF 

       730        740        750        760        770        780 
FYITVYNEPY PQPPEPENFD PDGVLRGMYR YYTAKEQRSN KAHILASGVS MPAALTAAEM 

       790        800        810        820        830        840 
LSTQWDVAAD VWSVTSWGEL NRDGMSIETA RLRYPDQPTS VPYVTQVLSE ARSDNAGPVI 

       850        860        870        880        890        900 
AVSDWMRAVP EQIRPWVPGT YVTLGTDGFG FSDTRTATRR YFNTDAESQV VAVLEALARD 

       910        920        930 
GEIDPSVPVA ATRQYQIDDV QAAPEQTSDP GPGVQN

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583922 Genomic DNA. Translation: CAC30602.1.
PIRE87115.
RefSeqNP_302132.1. NC_002677.1.

3D structure databases

HSSPHSSP built from PDB template 1L8A based on UniProtKB P06958.
ProteinModelPortalQ9CBS8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028499; EBMYCP00000028105; EBMYCG00000028494.
GeneID909973.
GenomeReviewsGene locus ML1651 in contig AL450380_GR.
KEGGmle:ML1651.
NMPDRfig|272631.1.peg.1004.
PATRIC18056374. VBIMycLep78757_3118.

Organism-specific databases

LepromaML1651.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016271.
HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9CBS8_MYCLE
AccessionPrimary (citable) accession number: Q9CBS8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info