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Q9CBS7

- FAB1_MYCLE

UniProt

Q9CBS7 - FAB1_MYCLE

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene

kasA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei171 – 1711By similarity

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase 1
    Short name:
    KAS 1
    Gene namesi
    Name:kasA
    Ordered Locus Names:ML1655
    ORF Names:MLCB1243.20c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1655.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4164163-oxoacyl-[acyl-carrier-protein] synthase 1PRO_0000180331Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML1655.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CBS7.
    SMRiQ9CBS7. Positions 10-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    KOiK11609.
    OMAiHAQKRNA.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9CBS7-1 [UniParc]FASTAAdd to Basket

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    MTMPSTANGG FPSVVVTAVT ATTSISPDIE STWKGLLAGE SGIHVLEDEY    50
    ITKWDLPVKI GGHLKEPVDS HMSRLDLRRM SYVQRMSKLL SGRLWESTGS 100
    PEVDPDRFTV VVGTGLGGAE RIVESYDLMN AGGPRKVSPL AVQMIMPNGA 150
    AATVGLQLGA CAGVMTPVSA CSSGSEAIAH AWRQIIMGDA DVAVCGGVEG 200
    PIEALPIAAF SMMRAMSTRN DDPEGASRPF DKNRDGFVFG EAGALMLIET 250
    EEHAKARGAK PLARLLGAGI TSDAFHMVAP AADGVRAGRA MTRSLELAGL 300
    SAKDVDHVNA HGTATPIGDS AEANAIRVAG CEQAAVYAPK SALGHSIGAV 350
    GALESVLTVL ALRDGVIPPT LNYQTPDPEI DLDIVAGEPR YGDYRYAINN 400
    SFGFGGHNVA LAFGRY 416
    Length:416
    Mass (Da):43,470
    Last modified:June 1, 2001 - v1
    Checksum:iF90F8210F022F4FC
    GO

    Sequence cautioni

    The sequence CAA19201.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023635 Genomic DNA. Translation: CAA19201.1. Different initiation.
    AL583922 Genomic DNA. Translation: CAC30606.1.
    PIRiA87116.
    T44711.
    RefSeqiNP_302136.1. NC_002677.1.
    WP_010908457.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30606; CAC30606; CAC30606.
    GeneIDi909994.
    KEGGimle:ML1655.
    PATRICi18056382. VBIMycLep78757_3122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023635 Genomic DNA. Translation: CAA19201.1 . Different initiation.
    AL583922 Genomic DNA. Translation: CAC30606.1 .
    PIRi A87116.
    T44711.
    RefSeqi NP_302136.1. NC_002677.1.
    WP_010908457.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CBS7.
    SMRi Q9CBS7. Positions 10-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30606 ; CAC30606 ; CAC30606 .
    GeneIDi 909994.
    KEGGi mle:ML1655.
    PATRICi 18056382. VBIMycLep78757_3122.

    Organism-specific databases

    Lepromai ML1655.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    KOi K11609.
    OMAi HAQKRNA.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiFAB1_MYCLE
    AccessioniPrimary (citable) accession number: Q9CBS7
    Secondary accession number(s): O69474
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3