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Q9CBS7

- FAB1_MYCLE

UniProt

Q9CBS7 - FAB1_MYCLE

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene

kasA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase 1
Short name:
KAS 1
Gene namesi
Name:kasA
Ordered Locus Names:ML1655
ORF Names:MLCB1243.20c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1655.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4164163-oxoacyl-[acyl-carrier-protein] synthase 1PRO_0000180331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1655.

Structurei

3D structure databases

ProteinModelPortaliQ9CBS7.
SMRiQ9CBS7. Positions 10-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK11609.
OMAiHAQKRNA.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9CBS7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMPSTANGG FPSVVVTAVT ATTSISPDIE STWKGLLAGE SGIHVLEDEY
60 70 80 90 100
ITKWDLPVKI GGHLKEPVDS HMSRLDLRRM SYVQRMSKLL SGRLWESTGS
110 120 130 140 150
PEVDPDRFTV VVGTGLGGAE RIVESYDLMN AGGPRKVSPL AVQMIMPNGA
160 170 180 190 200
AATVGLQLGA CAGVMTPVSA CSSGSEAIAH AWRQIIMGDA DVAVCGGVEG
210 220 230 240 250
PIEALPIAAF SMMRAMSTRN DDPEGASRPF DKNRDGFVFG EAGALMLIET
260 270 280 290 300
EEHAKARGAK PLARLLGAGI TSDAFHMVAP AADGVRAGRA MTRSLELAGL
310 320 330 340 350
SAKDVDHVNA HGTATPIGDS AEANAIRVAG CEQAAVYAPK SALGHSIGAV
360 370 380 390 400
GALESVLTVL ALRDGVIPPT LNYQTPDPEI DLDIVAGEPR YGDYRYAINN
410
SFGFGGHNVA LAFGRY
Length:416
Mass (Da):43,470
Last modified:June 1, 2001 - v1
Checksum:iF90F8210F022F4FC
GO

Sequence cautioni

The sequence CAA19201.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023635 Genomic DNA. Translation: CAA19201.1. Different initiation.
AL583922 Genomic DNA. Translation: CAC30606.1.
PIRiA87116.
T44711.
RefSeqiNP_302136.1. NC_002677.1.
WP_010908457.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30606; CAC30606; CAC30606.
GeneIDi909994.
KEGGimle:ML1655.
PATRICi18056382. VBIMycLep78757_3122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023635 Genomic DNA. Translation: CAA19201.1 . Different initiation.
AL583922 Genomic DNA. Translation: CAC30606.1 .
PIRi A87116.
T44711.
RefSeqi NP_302136.1. NC_002677.1.
WP_010908457.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CBS7.
SMRi Q9CBS7. Positions 10-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1655.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30606 ; CAC30606 ; CAC30606 .
GeneIDi 909994.
KEGGi mle:ML1655.
PATRICi 18056382. VBIMycLep78757_3122.

Organism-specific databases

Lepromai ML1655.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060166.
KOi K11609.
OMAi HAQKRNA.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiFAB1_MYCLE
AccessioniPrimary (citable) accession number: Q9CBS7
Secondary accession number(s): O69474
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3