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Q9CBS7 (FAB1_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1

EC=2.3.1.41
Alternative name(s):
Beta-ketoacyl-ACP synthase 1
Short name=KAS 1
Gene names
Name:kasA
Ordered Locus Names:ML1655
ORF Names:MLCB1243.20c
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence caution

The sequence CAA19201.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4164163-oxoacyl-[acyl-carrier-protein] synthase 1
PRO_0000180331

Sites

Active site1711 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CBS7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F90F8210F022F4FC

FASTA41643,470
        10         20         30         40         50         60 
MTMPSTANGG FPSVVVTAVT ATTSISPDIE STWKGLLAGE SGIHVLEDEY ITKWDLPVKI 

        70         80         90        100        110        120 
GGHLKEPVDS HMSRLDLRRM SYVQRMSKLL SGRLWESTGS PEVDPDRFTV VVGTGLGGAE 

       130        140        150        160        170        180 
RIVESYDLMN AGGPRKVSPL AVQMIMPNGA AATVGLQLGA CAGVMTPVSA CSSGSEAIAH 

       190        200        210        220        230        240 
AWRQIIMGDA DVAVCGGVEG PIEALPIAAF SMMRAMSTRN DDPEGASRPF DKNRDGFVFG 

       250        260        270        280        290        300 
EAGALMLIET EEHAKARGAK PLARLLGAGI TSDAFHMVAP AADGVRAGRA MTRSLELAGL 

       310        320        330        340        350        360 
SAKDVDHVNA HGTATPIGDS AEANAIRVAG CEQAAVYAPK SALGHSIGAV GALESVLTVL 

       370        380        390        400        410 
ALRDGVIPPT LNYQTPDPEI DLDIVAGEPR YGDYRYAINN SFGFGGHNVA LAFGRY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL023635 Genomic DNA. Translation: CAA19201.1. Different initiation.
AL583922 Genomic DNA. Translation: CAC30606.1.
PIRA87116.
T44711.
RefSeqNP_302136.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CBS7.
SMRQ9CBS7. Positions 10-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1655.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30606; CAC30606; CAC30606.
GeneID909994.
KEGGmle:ML1655.
PATRIC18056382. VBIMycLep78757_3122.

Organism-specific databases

LepromaML1655.
CMRSearch...

Phylogenomic databases

eggNOGCOG0304.
HOGENOMHOG000060166.
KOK11609.
OMATVFSEHA.
OrthoDBEOG6DG2SR.
ProtClustDBPRK07314.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 2 hits.
ProtoNetSearch...

Entry information

Entry nameFAB1_MYCLE
AccessionPrimary (citable) accession number: Q9CBS7
Secondary accession number(s): O69474
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways