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Q9CBS0 (DDL_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Synonyms:ddlA
Ordered Locus Names:ML1678
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000177842

Regions

Domain167 – 374208ATP-grasp
Nucleotide binding195 – 25056ATP By similarity

Sites

Metal binding3291Magnesium or manganese 1 By similarity
Metal binding3411Magnesium or manganese 1 By similarity
Metal binding3411Magnesium or manganese 2 By similarity
Metal binding3431Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CBS0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F6CF12BA4AE15213

FASTA38440,981
        10         20         30         40         50         60 
MNVYQRPLMP WLPSGGRVRV AVVFGGRSNE HAVSCLSAGS ILRNLDRQRF DVVAVGITPE 

        70         80         90        100        110        120 
GTWMLTDPNP DALAIANRQL PAVSCESGIE LTLPADPRRS GQLVSLSHGA GLGAGEVLTS 

       130        140        150        160        170        180 
VDVVFPVLHG PYGEDGTIQG LLELARVPYV GAGVLASAAG MDKEFTKKLF AAEGLPLSAY 

       190        200        210        220        230        240 
TVLRPLRPTL HRQECERLSL PVFVKPARGG SSIGISRVSS WGQLPSAIAY ARRHDPKVIV 

       250        260        270        280        290        300 
EAAVNGRELE CGVLEMPDGT VAASAVGEIR VAGVSGSEDS FYDFTTKYLD DAAELDVPAK 

       310        320        330        340        350        360 
VDDDVADEVR QLAIQAFRAI DCQGLARVDF FLTDDGPVIN EINTMPGFTM TSMYPKLWAV 

       370        380 
SSVDYPTLLA TMVDTALARG VGMR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583923 Genomic DNA. Translation: CAC30631.1.
PIRH87118.
RefSeqNP_302152.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CBS0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1678.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30631; CAC30631; CAC30631.
GeneID910044.
KEGGmle:ML1678.
PATRIC18056478. VBIMycLep78757_3170.

Organism-specific databases

LepromaML1678.
CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_MYCLE
AccessionPrimary (citable) accession number: Q9CBS0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways