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Q9CBQ5

- COX1_MYCLE

UniProt

Q9CBQ5 - COX1_MYCLE

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Protein

Probable cytochrome c oxidase subunit 1

Gene
ctaD, ML1728
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Iron (heme A axial ligand) By similarity
Metal bindingi264 – 2641Copper B By similarity
Metal bindingi268 – 2681Copper B By similarity
Metal bindingi313 – 3131Copper B By similarity
Metal bindingi314 – 3141Copper B By similarity
Metal bindingi397 – 3971Iron (heme A3 axial ligand) By similarity
Metal bindingi399 – 3991Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:ML1728
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1728.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021Helical; Reviewed predictionAdd
BLAST
Transmembranei89 – 10921Helical; Reviewed predictionAdd
BLAST
Transmembranei121 – 14121Helical; Reviewed predictionAdd
BLAST
Transmembranei170 – 19021Helical; Reviewed predictionAdd
BLAST
Transmembranei213 – 23321Helical; Reviewed predictionAdd
BLAST
Transmembranei258 – 27821Helical; Reviewed predictionAdd
BLAST
Transmembranei290 – 31021Helical; Reviewed predictionAdd
BLAST
Transmembranei315 – 33521Helical; Reviewed predictionAdd
BLAST
Transmembranei359 – 37921Helical; Reviewed predictionAdd
BLAST
Transmembranei398 – 41821Helical; Reviewed predictionAdd
BLAST
Transmembranei433 – 45321Helical; Reviewed predictionAdd
BLAST
Transmembranei476 – 49621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Probable cytochrome c oxidase subunit 1PRO_0000183441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki264 ↔ 2681'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi272631.ML1728.

Structurei

3D structure databases

ProteinModelPortaliQ9CBQ5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085275.
KOiK02274.
OMAiMGMTRRV.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CBQ5-1 [UniParc]FASTAAdd to Basket

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MTAEALSSGE LKAIRPYPAR TGPKGNLVYK LITTTDHKMI GIMYCVACFI    50
FFFVGGLLAL LMRTELAAPG LQFLSNEQFN QLFTMHGTIM LLFYATPIVF 100
GFANLVLPLQ IGAPDVAFPR LNAFSFWLFL FGAAIGMAGF ITPGGAADFG 150
WTAYTPLTDA IHSPGVGGDL WIMGLIVAGL GTILGAVNMI TTVVCLRAPG 200
MTMFRMPIFT WNILVTSILV LIAFPLLTAA LFGLAADRHL GAHIYDAANG 250
GVLLWQHLFW FFGHPEVYII ALPFFGIVSE IFPVFSRKPI FGYTTLVYAT 300
LSIAALSVAV WAHHMFATGA VLLPFFSFMT YLIAVPTGIK FFNWVGTMWK 350
GQLTFETPML FSVGFAVTFL LGGLTGVLLA SPPLDFHVTD SYFVVAHFHY 400
VLFGTIVFST FAGIYFWFPK MTGRLLDEQL GKLHFWLTFI GFHTTFLVQH 450
WLGDMGMPRR YADYLPTDGF QGLNVVSTIG SFILGASMFP FVWNVFKSWR 500
YGEVVTVDDP WGYGNSLEWA TSCPPPRHNF TELPRIRSER PAFELHYPHM 550
VERLRDEAYV GRRHAEELVE VSLH 574
Length:574
Mass (Da):63,957
Last modified:June 1, 2001 - v1
Checksum:i9CFE8C610E09F475
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583923 Genomic DNA. Translation: CAC30681.1.
PIRiB87125.
RefSeqiNP_302190.1. NC_002677.1.
WP_010908511.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30681; CAC30681; CAC30681.
GeneIDi910765.
KEGGimle:ML1728.
PATRICi18056644. VBIMycLep78757_3251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583923 Genomic DNA. Translation: CAC30681.1 .
PIRi B87125.
RefSeqi NP_302190.1. NC_002677.1.
WP_010908511.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CBQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30681 ; CAC30681 ; CAC30681 .
GeneIDi 910765.
KEGGi mle:ML1728.
PATRICi 18056644. VBIMycLep78757_3251.

Organism-specific databases

Lepromai ML1728.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085275.
KOi K02274.
OMAi MGMTRRV.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiCOX1_MYCLE
AccessioniPrimary (citable) accession number: Q9CBQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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