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Q9CBQ2

- RIR2_MYCLE

UniProt

Q9CBQ2 - RIR2_MYCLE

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Iron 1PROSITE-ProRule annotation
Metal bindingi104 – 1041Iron 1PROSITE-ProRule annotation
Metal bindingi104 – 1041Iron 2By similarity
Metal bindingi107 – 1071Iron 1PROSITE-ProRule annotation
Active sitei111 – 1111PROSITE-ProRule annotation
Metal bindingi164 – 1641Iron 2By similarity
Metal bindingi198 – 1981Iron 2By similarity
Metal bindingi201 – 2011Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdF
Ordered Locus Names:ML1731
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1731.

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Ribonucleoside-diphosphate reductase subunit betaPRO_0000190485Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi272631.ML1731.

Structurei

3D structure databases

ProteinModelPortaliQ9CBQ2.
SMRiQ9CBQ2. Positions 10-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
HOGENOMiHOG000246153.
KOiK00526.
OMAiNDIPSWQ.
OrthoDBiEOG68DD19.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR026494. RNR_NrdF.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CBQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTGKMKLID RVSAINWNWL QDDKDAEVWD RLTGNFWLPE KVPVSNDLPS
60 70 80 90 100
WGTLTASEKQ LTMRVFTGLT LLDTIQGTVG AVSLIPDALT PHEEAVYTNI
110 120 130 140 150
AFMESVHAKS YSSIFSTLCS TAEIDEAFRW SEENNNLQRK AKIVMEYYRG
160 170 180 190 200
DEPLKRKVAS TLLESFLFYS GFYLPMYWSS RAKLTNTADM IRLIIRDEAV
210 220 230 240 250
HGYYIGYKFQ RGLVLVDDAR RAELKEYTYE LLFELYDNEV EYTQDLYDRV
260 270 280 290 300
GLTEDVKKFL RYNANKALMN LGYEALFPRD ETDVNPAILS ALSPNADENH
310 320
DFFSGSGSSY VIGKAVVTED EDWDF
Length:325
Mass (Da):37,316
Last modified:June 1, 2001 - v1
Checksum:iA80D29751183358B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583923 Genomic DNA. Translation: CAC30684.1.
PIRiE87125.
RefSeqiNP_302193.1. NC_002677.1.
WP_010908514.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30684; CAC30684; CAC30684.
GeneIDi910762.
KEGGimle:ML1731.
PATRICi18056654. VBIMycLep78757_3256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583923 Genomic DNA. Translation: CAC30684.1 .
PIRi E87125.
RefSeqi NP_302193.1. NC_002677.1.
WP_010908514.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CBQ2.
SMRi Q9CBQ2. Positions 10-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30684 ; CAC30684 ; CAC30684 .
GeneIDi 910762.
KEGGi mle:ML1731.
PATRICi 18056654. VBIMycLep78757_3256.

Organism-specific databases

Lepromai ML1731.

Phylogenomic databases

eggNOGi COG0208.
HOGENOMi HOG000246153.
KOi K00526.
OMAi NDIPSWQ.
OrthoDBi EOG68DD19.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR026494. RNR_NrdF.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR04171. RNR_1b_NrdF. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiRIR2_MYCLE
AccessioniPrimary (citable) accession number: Q9CBQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3