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Q9CBQ2 (RIR2_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdF
Ordered Locus Names:ML1731
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190485

Sites

Active site1111 By similarity
Metal binding731Iron 1 By similarity
Metal binding1041Iron 1 By similarity
Metal binding1041Iron 2 By similarity
Metal binding1071Iron 1 By similarity
Metal binding1641Iron 2 By similarity
Metal binding1981Iron 2 By similarity
Metal binding2011Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CBQ2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A80D29751183358B

FASTA32537,316
        10         20         30         40         50         60 
MLTGKMKLID RVSAINWNWL QDDKDAEVWD RLTGNFWLPE KVPVSNDLPS WGTLTASEKQ 

        70         80         90        100        110        120 
LTMRVFTGLT LLDTIQGTVG AVSLIPDALT PHEEAVYTNI AFMESVHAKS YSSIFSTLCS 

       130        140        150        160        170        180 
TAEIDEAFRW SEENNNLQRK AKIVMEYYRG DEPLKRKVAS TLLESFLFYS GFYLPMYWSS 

       190        200        210        220        230        240 
RAKLTNTADM IRLIIRDEAV HGYYIGYKFQ RGLVLVDDAR RAELKEYTYE LLFELYDNEV 

       250        260        270        280        290        300 
EYTQDLYDRV GLTEDVKKFL RYNANKALMN LGYEALFPRD ETDVNPAILS ALSPNADENH 

       310        320 
DFFSGSGSSY VIGKAVVTED EDWDF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583923 Genomic DNA. Translation: CAC30684.1.
PIRE87125.
RefSeqNP_302193.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CBQ2.
SMRQ9CBQ2. Positions 10-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1731.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30684; CAC30684; CAC30684.
GeneID910762.
KEGGmle:ML1731.
PATRIC18056654. VBIMycLep78757_3256.

Organism-specific databases

LepromaML1731.
CMRSearch...

Phylogenomic databases

eggNOGCOG0208.
HOGENOMHOG000246153.
KOK00526.
OMANDIPSWQ.
OrthoDBEOG68DD19.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026494. RNR_1b_NrdF.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFPIRSF000355. NrdB. 1 hit.
SUPFAMSSF47240. SSF47240. 1 hit.
TIGRFAMsTIGR04171. RNR_1b_NrdF. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_MYCLE
AccessionPrimary (citable) accession number: Q9CBQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways