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Q9CBQ2

- RIR2_MYCLE

UniProt

Q9CBQ2 - RIR2_MYCLE

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi73 – 731Iron 1PROSITE-ProRule annotation
    Metal bindingi104 – 1041Iron 1PROSITE-ProRule annotation
    Metal bindingi104 – 1041Iron 2By similarity
    Metal bindingi107 – 1071Iron 1PROSITE-ProRule annotation
    Active sitei111 – 1111PROSITE-ProRule annotation
    Metal bindingi164 – 1641Iron 2By similarity
    Metal bindingi198 – 1981Iron 2By similarity
    Metal bindingi201 – 2011Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdF
    Ordered Locus Names:ML1731
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1731.

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Ribonucleoside-diphosphate reductase subunit betaPRO_0000190485Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML1731.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CBQ2.
    SMRiQ9CBQ2. Positions 10-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    HOGENOMiHOG000246153.
    KOiK00526.
    OMAiNDIPSWQ.
    OrthoDBiEOG68DD19.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR026494. RNR_NrdF.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000355. NrdB. 1 hit.
    SUPFAMiSSF47240. SSF47240. 1 hit.
    TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CBQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTGKMKLID RVSAINWNWL QDDKDAEVWD RLTGNFWLPE KVPVSNDLPS    50
    WGTLTASEKQ LTMRVFTGLT LLDTIQGTVG AVSLIPDALT PHEEAVYTNI 100
    AFMESVHAKS YSSIFSTLCS TAEIDEAFRW SEENNNLQRK AKIVMEYYRG 150
    DEPLKRKVAS TLLESFLFYS GFYLPMYWSS RAKLTNTADM IRLIIRDEAV 200
    HGYYIGYKFQ RGLVLVDDAR RAELKEYTYE LLFELYDNEV EYTQDLYDRV 250
    GLTEDVKKFL RYNANKALMN LGYEALFPRD ETDVNPAILS ALSPNADENH 300
    DFFSGSGSSY VIGKAVVTED EDWDF 325
    Length:325
    Mass (Da):37,316
    Last modified:June 1, 2001 - v1
    Checksum:iA80D29751183358B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583923 Genomic DNA. Translation: CAC30684.1.
    PIRiE87125.
    RefSeqiNP_302193.1. NC_002677.1.
    WP_010908514.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30684; CAC30684; CAC30684.
    GeneIDi910762.
    KEGGimle:ML1731.
    PATRICi18056654. VBIMycLep78757_3256.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583923 Genomic DNA. Translation: CAC30684.1 .
    PIRi E87125.
    RefSeqi NP_302193.1. NC_002677.1.
    WP_010908514.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali Q9CBQ2.
    SMRi Q9CBQ2. Positions 10-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30684 ; CAC30684 ; CAC30684 .
    GeneIDi 910762.
    KEGGi mle:ML1731.
    PATRICi 18056654. VBIMycLep78757_3256.

    Organism-specific databases

    Lepromai ML1731.

    Phylogenomic databases

    eggNOGi COG0208.
    HOGENOMi HOG000246153.
    KOi K00526.
    OMAi NDIPSWQ.
    OrthoDBi EOG68DD19.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR026494. RNR_NrdF.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000355. NrdB. 1 hit.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    TIGRFAMsi TIGR04171. RNR_1b_NrdF. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiRIR2_MYCLE
    AccessioniPrimary (citable) accession number: Q9CBQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3