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Reviewed, UniProtKB/Swiss-Prot Q9CBM9 (CBL_MYCLE)

Last modified November 3, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Putative cystathionine beta-lyase
      Short name=CBL
    EC=4.4.1.8
Alternative name(s):
    Beta-cystathionase
    Cysteine lyase
Gene names
Ordered Locus Names: ML1794
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.

Cofactor

Pyridoxal phosphate By similarity.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/patB cystathionine beta-lyase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Putative cystathionine beta-lyase
PRO_0000163849

Amino acid modifications

Modified residue2361N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CBM9-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7696E8684CB220D6

FASTA40243,861
        10         20         30         40         50         60 
MTSNPLEQLT IEQLQCRTSM KWRAHPEDVL PLWVAEMDVL LAPTVAEAVH RAVDNGDTGY 

        70         80         90        100        110        120 
PYGTTFAEAI SEFASQRWQW HDLDVSRTAI VPDVMLGVVE MLRLITDRGD GVIVSPPVYP 

       130        140        150        160        170        180 
PFYAFVTHDG RRVLEAPLGR DGRLDLAALQ DAFSRARRSS GPNGKVAYLL CNPHNPTGSV 

       190        200        210        220        230        240 
HTVAELHGVA ELARRFGVRV ISDEIHAPLV LSGARFTPYL SIPGAENAFA LMSATKGWNL 

       250        260        270        280        290        300 
CGLKAAIAIA GREAAADLRR IPKEVSHGPS HLGIIAHTAA FRTGSSWLDA LLQGLEANRA 

       310        320        330        340        350        360 
LLRDLVTKHL PGVRYQRPQG TYLTWLDCRH LGFDEQINEG LAAISDLSGP ARWFLDHSRV 

       370        380        390        400 
ALTSGHAFGT GGVGHVRVNF ATSQAILIEA LSRMGRALVN FR 

« Hide

Cross-references

Sequence databases

AL583923 Genomic DNA. Translation: CAC30747.1.
PIRC87133.
RefSeqNP_302217.1.

3D structure databases

HSSPHSSP built from PDB template 1GC0 based on UniProtKB P13254.
ModBaseSearch...

Genome annotation databases

GeneID910697.
GenomeReviewsGene locus ML1794 in contig AL450380_GR.
KEGGmle:ML1794.
NMPDRfig|272631.1.peg.1089.

Organism-specific databases

LepromaML1794.
CMRSearch...

Phylogenomic databases

HOGENOMQ9CBM9.
OMAPEEVSHG.

Enzyme and pathway databases

BioCycMLEP272631:ML1794-MON.

Family and domain databases

InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PROSITEPS00599. AA_TRANSFER_CLASS_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBL_MYCLE
AccessionPrimary (citable) accession number: Q9CBM9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents