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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH]

Gene

inhA

Organism
Mycobacterium leprae (strain TN)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH]UniRule annotation (EC:1.3.1.9UniRule annotation)
Gene namesi
Name:inhAImported
OrganismiMycobacterium leprae (strain TN)Imported
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1806.

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1806.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NTVX-ray2.10A/B2-269[»]
ProteinModelPortaliQ9CBM1.
SMRiQ9CBM1. Positions 2-269.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CBM1.

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSJ. Bacteria.
COG0623. LUCA.
KOiK11611.
OMAiSACKREG.
OrthoDBiEOG6HF644.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PTHR24322:SF317. PTHR24322:SF317. 1 hit.
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CBM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLLEGKRI LVSGIITDSS IAFHIAKVAQ EAGAQLVLTG FDRLRLIQRI
60 70 80 90 100
ADRLPDKAPL IELDVQNEEH LATLAERVTA EIGEGNKLDG VVHSIGFMPQ
110 120 130 140 150
TGMGTNQFFD APYEDVSKGI HISTYSYASL AKALLLIMNS GGSIVGMDFD
160 170 180 190 200
PTRAMPAYNW MTVAKSALES VNRFVAREAG KYGVRSNLVA AGPIRTLAMS
210 220 230 240 250
AIVGGAFGEE AGAQMQLLEE GWDQRAPIGW NMKDPTPVAK TVCALLSEWL
260
PATTGSIIYA DGGASTQLL
Length:269
Mass (Da):28,708
Last modified:June 1, 2001 - v1
Checksum:iA8658A1DF93F6734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583923 Genomic DNA. Translation: CAC30759.1.
PIRiG87134.
RefSeqiNP_302227.1. NC_002677.1.
WP_010908548.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30759; CAC30759; CAC30759.
GeneIDi910685.
KEGGimle:ML1806.
PATRICi18057008. VBIMycLep78757_3431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583923 Genomic DNA. Translation: CAC30759.1.
PIRiG87134.
RefSeqiNP_302227.1. NC_002677.1.
WP_010908548.1. NC_002677.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NTVX-ray2.10A/B2-269[»]
ProteinModelPortaliQ9CBM1.
SMRiQ9CBM1. Positions 2-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1806.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30759; CAC30759; CAC30759.
GeneIDi910685.
KEGGimle:ML1806.
PATRICi18057008. VBIMycLep78757_3431.

Organism-specific databases

LepromaiML1806.

Phylogenomic databases

eggNOGiENOG4105CSJ. Bacteria.
COG0623. LUCA.
KOiK11611.
OMAiSACKREG.
OrthoDBiEOG6HF644.

Enzyme and pathway databases

UniPathwayiUPA00094.

Miscellaneous databases

EvolutionaryTraceiQ9CBM1.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PTHR24322:SF317. PTHR24322:SF317. 1 hit.
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TNImported.
  2. "Mechanism of thioamide drug action against tuberculosis and leprosy."
    Wang F., Langley R., Gulten G., Dover L.G., Besra G.S., Jacobs W.R., Sacchettini J.C.
    J. Exp. Med. 204:73-78(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-269.

Entry informationi

Entry nameiQ9CBM1_MYCLE
AccessioniPrimary (citable) accession number: Q9CBM1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 13, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.