Enoyl-[acyl-carrier-protein] reductase [NADH] - Mycobacterium leprae

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Q9CBM1 (Q9CBM1_MYCLE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 61. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] PIRNR PIRNR000094
EC=1.3.1.9 PIRNR PIRNR000094

Gene names

Name:	inhA EMBL CAC30759.1
Ordered Locus Names:	ML1806

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD⁺ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH. PIRNR PIRNR000094
Pathway	Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000094
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. PIRNR PIRNR000094

Ontologies

Keywords
Biological process	Fatty acid biosynthesis PIRNR PIRNR000094 Lipid synthesis
Ligand	NAD PIRNR PIRNR000094
Molecular function	Oxidoreductase PIRNR PIRNR000094
Technical term	3D-structure PDB 2NTV Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Active site

1

Proton acceptor By similarity PIRSR PIRSR000094-1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9CBM1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A8658A1DF93F6734
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269

28,708

        10         20         30         40         50         60 
MAGLLEGKRI LVSGIITDSS IAFHIAKVAQ EAGAQLVLTG FDRLRLIQRI ADRLPDKAPL 

        70         80         90        100        110        120 
IELDVQNEEH LATLAERVTA EIGEGNKLDG VVHSIGFMPQ TGMGTNQFFD APYEDVSKGI 

       130        140        150        160        170        180 
HISTYSYASL AKALLLIMNS GGSIVGMDFD PTRAMPAYNW MTVAKSALES VNRFVAREAG 

       190        200        210        220        230        240 
KYGVRSNLVA AGPIRTLAMS AIVGGAFGEE AGAQMQLLEE GWDQRAPIGW NMKDPTPVAK 

       250        260 
TVCALLSEWL PATTGSIIYA DGGASTQLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
[2]	"Mechanism of thioamide drug action against tuberculosis and leprosy." Wang F., Langley R., Gulten G., Dover L.G., Besra G.S., Jacobs W.R., Sacchettini J.C. J. Exp. Med. 204:73-78(2007) [PubMed: 17227913] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-269.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL583923 Genomic DNA. Translation: CAC30759.1.

PIR

RefSeq

NP_302227.1. NC_002677.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2NTV	X-ray	2.10	A/B	2-269	[»]

ProteinModelPortal

SMR

Q9CBM1. Positions 2-269.

ModBase

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

EBMYCT00000029136; EBMYCP00000028742; EBMYCG00000029131.

GeneID

GenomeReviews

Gene locus ML1806 in contig AL450380_GR.

KEGG

NMPDR

fig|272631.1.peg.1099.

PATRIC

18057008. VBIMycLep78757_3431.

Organism-specific databases

Leproma

CMR

Phylogenomic databases

GeneTree

EBGT00050000015205.

HOGENOM

OMA

ProtClustDB

Family and domain databases

InterPro

IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

KO

PIRSF

PIRSF000094. Enoyl-ACP_rdct. 1 hit.

ProtoNet

Entry information

Entry name

Q9CBM1_MYCLE

Accession

Primary (citable) accession number: Q9CBM1

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info