Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Enoyl-[acyl-carrier-protein] reductase [NADH]

Gene

inhA

Organism
Mycobacterium leprae (strain TN)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14NAD; via carbonyl oxygenUniRule annotation1
Binding sitei95NAD; via carbonyl oxygenUniRule annotation1
Binding sitei165NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 21NADUniRule annotation2
Nucleotide bindingi64 – 65NADUniRule annotation2
Nucleotide bindingi194 – 198NADUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADUniRule annotation

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1980-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH]UniRule annotation (EC:1.3.1.9UniRule annotation)
Gene namesi
Name:inhAImported
OrganismiMycobacterium leprae (strain TN)Imported
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1806

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1806

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NTVX-ray2.10A/B2-269[»]
ProteinModelPortaliQ9CBM1
SMRiQ9CBM1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CBM1

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSJ Bacteria
COG0623 LUCA
KOiK11611
OMAiGILDMIH
OrthoDBiPOG091H06HU

Family and domain databases

InterProiView protein in InterPro
IPR014358 Enoyl-ACP_Rdtase_NADH
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR43159:SF2 PTHR43159:SF2, 1 hit
PIRSFiPIRSF000094 Enoyl-ACP_rdct, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CBM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLLEGKRI LVSGIITDSS IAFHIAKVAQ EAGAQLVLTG FDRLRLIQRI
60 70 80 90 100
ADRLPDKAPL IELDVQNEEH LATLAERVTA EIGEGNKLDG VVHSIGFMPQ
110 120 130 140 150
TGMGTNQFFD APYEDVSKGI HISTYSYASL AKALLLIMNS GGSIVGMDFD
160 170 180 190 200
PTRAMPAYNW MTVAKSALES VNRFVAREAG KYGVRSNLVA AGPIRTLAMS
210 220 230 240 250
AIVGGAFGEE AGAQMQLLEE GWDQRAPIGW NMKDPTPVAK TVCALLSEWL
260
PATTGSIIYA DGGASTQLL
Length:269
Mass (Da):28,708
Last modified:June 1, 2001 - v1
Checksum:iA8658A1DF93F6734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583923 Genomic DNA Translation: CAC30759.1
PIRiG87134
RefSeqiNP_302227.1, NC_002677.1
WP_010908548.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30759; CAC30759; CAC30759
GeneIDi910685
KEGGimle:ML1806
PATRICifig|272631.5.peg.3431

Similar proteinsi

Entry informationi

Entry nameiQ9CBM1_MYCLE
AccessioniPrimary (citable) accession number: Q9CBM1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health