Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9CBI6 (SODC_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Cu-Zn]

EC=1.15.1.1
Gene names
Name:sodC
Ordered Locus Names:ML1925
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes By similarity.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 copper ion per subunit Potential.

Binds 1 zinc ion per subunit Potential.

Subcellular location

Cell membrane; Lipid-anchor By similarity.

Sequence similarities

Belongs to the Cu-Zn superoxide dismutase family.

Caution

Lacks three conserved histidine residues and one conserved aspartate residue that bind copper and zinc.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
   LigandCopper
Metal-binding
Zinc
   Molecular functionAntioxidant
Oxidoreductase
   PTMDisulfide bond
Lipoprotein
Palmitate
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 240208Superoxide dismutase [Cu-Zn]
PRO_0000032838

Sites

Metal binding1161Copper; catalytic By similarity
Metal binding1181Copper; catalytic By similarity
Metal binding1951Copper; catalytic By similarity

Amino acid modifications

Lipidation331N-palmitoyl cysteine Potential
Lipidation331S-diacylglycerol cysteine Potential
Disulfide bond123 ↔ 234 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CBI6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F042C680D80799DD

FASTA24024,087
        10         20         30         40         50         60 
MSKLAGHRNV AAVTRSALSL SFVAACVALL SACIQNQPPA TLPGTTPTVW TGSPAPSGML 

        70         80         90        100        110        120 
GAEAESMGPP NIITRLNAPD GTQVATAKFE FNNGFATITI ATTGVGHLAP GFHGVHIHKV 

       130        140        150        160        170        180 
GKCEPSSAGP TGGAPGDFLS AGGHFQVPGH TVEPASGNLT SLQVRKDGIG TLVTTTDAFT 

       190        200        210        220        230        240 
MNDLLAGQKT AIIIHAGADN FGNIPPERYS QVNGTPGPDA TTISTGDAGK RVACGVIGAD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583923 Genomic DNA. Translation: CAC30880.1.
PIRH87149.
RefSeqNP_302298.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CBI6.
SMRQ9CBI6. Positions 71-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1925.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC30880; CAC30880; CAC30880.
GeneID910108.
KEGGmle:ML1925.
PATRIC18057442. VBIMycLep78757_3645.

Organism-specific databases

LepromaML1925.
CMRSearch...

Phylogenomic databases

eggNOGCOG2032.
HOGENOMHOG000263448.
KOK04565.
OMAYNQTNGT.
OrthoDBEOG6K13RS.

Family and domain databases

Gene3D2.60.40.200. 1 hit.
InterProIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMSSF49329. SSF49329. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSODC_MYCLE
AccessionPrimary (citable) accession number: Q9CBI6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families