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Q9CBI6

- SODC_MYCLE

UniProt

Q9CBI6 - SODC_MYCLE

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Protein
Superoxide dismutase [Cu-Zn]
Gene
sodC, ML1925
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes By similarity.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 copper ion per subunit Reviewed prediction.
Binds 1 zinc ion per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi116 – 1161Copper; catalytic By similarity
Metal bindingi118 – 1181Copper; catalytic By similarity
Metal bindingi195 – 1951Copper; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
Ordered Locus Names:ML1925
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1925.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 240208Superoxide dismutase [Cu-Zn]
PRO_0000032838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi33 – 331N-palmitoyl cysteine Reviewed prediction
Lipidationi33 – 331S-diacylglycerol cysteine Reviewed prediction
Disulfide bondi123 ↔ 234 By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1925.

Structurei

3D structure databases

ProteinModelPortaliQ9CBI6.
SMRiQ9CBI6. Positions 71-239.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiYNQTNGT.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CBI6-1 [UniParc]FASTAAdd to Basket

« Hide

MSKLAGHRNV AAVTRSALSL SFVAACVALL SACIQNQPPA TLPGTTPTVW    50
TGSPAPSGML GAEAESMGPP NIITRLNAPD GTQVATAKFE FNNGFATITI 100
ATTGVGHLAP GFHGVHIHKV GKCEPSSAGP TGGAPGDFLS AGGHFQVPGH 150
TVEPASGNLT SLQVRKDGIG TLVTTTDAFT MNDLLAGQKT AIIIHAGADN 200
FGNIPPERYS QVNGTPGPDA TTISTGDAGK RVACGVIGAD 240
Length:240
Mass (Da):24,087
Last modified:June 1, 2001 - v1
Checksum:iF042C680D80799DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583923 Genomic DNA. Translation: CAC30880.1.
PIRiH87149.
RefSeqiNP_302298.1. NC_002677.1.
WP_010908619.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30880; CAC30880; CAC30880.
GeneIDi910108.
KEGGimle:ML1925.
PATRICi18057442. VBIMycLep78757_3645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583923 Genomic DNA. Translation: CAC30880.1 .
PIRi H87149.
RefSeqi NP_302298.1. NC_002677.1.
WP_010908619.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9CBI6.
SMRi Q9CBI6. Positions 71-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1925.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30880 ; CAC30880 ; CAC30880 .
GeneIDi 910108.
KEGGi mle:ML1925.
PATRICi 18057442. VBIMycLep78757_3645.

Organism-specific databases

Lepromai ML1925.

Phylogenomic databases

eggNOGi COG2032.
HOGENOMi HOG000263448.
KOi K04565.
OMAi YNQTNGT.
OrthoDBi EOG6K13RS.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiSODC_MYCLE
AccessioniPrimary (citable) accession number: Q9CBI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks three conserved histidine residues and one conserved aspartate residue that bind copper and zinc.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi