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Q9CBE9 (Q9CBE9_MYCLE) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL CAC31020.1
Ordered Locus Names:ML2065
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding17 – 226NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding40 – 423NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding82 – 843NADP By similarity PIRSR PIRSR000109-3
Region136 – 1383Substrate binding By similarity PIRSR PIRSR000109-2
Region193 – 1942Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1901Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1971Proton donor By similarity PIRSR PIRSR000109-1
Binding site1101NADP By similarity PIRSR PIRSR000109-3
Binding site1101Substrate By similarity PIRSR PIRSR000109-2
Binding site1981Substrate By similarity PIRSR PIRSR000109-2
Binding site2681Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2951Substrate By similarity PIRSR PIRSR000109-2
Binding site4531Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4591Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q9CBE9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 034E2A84A8D677F7

FASTA48352,005
        10         20         30         40         50         60 
MSAPESKTAI AQIGVTGLAV MGSNIARNFA RHGYTVALHN RSIAKTDTLL KEHGSEGNFV 

        70         80         90        100        110        120 
RTETIPEFLA ALQTPRRVLI MVKAGDATDA VINELADVME PSDIIIDGGN SLFTDTIRRE 

       130        140        150        160        170        180 
KAMRERGLHF VGAGISGGEE GALNGPSIMP GGPAESYTSL GPLLEEISAH VDGVSCCTHI 

       190        200        210        220        230        240 
GPGGSGHFVK MVHNGIEYSD MQLIGEAYQL LRDGLGMSAP QIADVFTEWN RGDLNSYLVE 

       250        260        270        280        290        300 
ITAEVLRQTD IKTGRPLVDV ILDKAEQKGT GRWTVQSALD LGVPITGIAE AVFARALSGS 

       310        320        330        340        350        360 
VLQRKAAIGL ASGKLGNKPT DRETFIEDVR QALYASKIVA YAQGFNHIQT GSTEFGWNIT 

       370        380        390        400        410        420 
PGDLATIWRG GCIIRAKFLN RIKEAFDAAP DLASLIVAPY FRSAVESAID SWRRVVSTAT 

       430        440        450        460        470        480 
QLGIPNPGFS SALSYYDALR TERLPAALTQ AQRDFFGAHS YGRVDARGKF HTLWSEDRSE 


VTV

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583924 Genomic DNA. Translation: CAC31020.1.
PIRD87167.
RefSeqNP_302377.1. NC_002677.1.

3D structure databases

HSSPHSSP built from PDB template 2PGD based on UniProtKB P00349.
ProteinModelPortalQ9CBE9.
SMRQ9CBE9. Positions 11-475.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029363; EBMYCP00000028969; EBMYCG00000029358.
GeneID908971.
GenomeReviewsGene locus ML2065 in contig AL450380_GR.
KEGGmle:ML2065.
NMPDRfig|272631.1.peg.1249.
PATRIC18057925. VBIMycLep78757_3886.

Organism-specific databases

LepromaML2065.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015862.
HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ9CBE9_MYCLE
AccessionPrimary (citable) accession number: Q9CBE9
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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