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Q9CBC2 (Q9CBC2_MYCLE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370
Gene names
Name:purM EMBL CAC31160.1
Ordered Locus Names:ML2205
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733

Subcellular location

Cytoplasm By similarity SAAS SAAS004733.

Sequence similarities

Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
   Biological processPurine biosynthesis SAAS SAAS004733
   Cellular componentCytoplasm SAAS SAAS004733
   LigandATP-binding SAAS SAAS004733
Nucleotide-binding
   Molecular functionLigase RuleBase RU004370 SAAS SAAS004733
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9CBC2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A51DD47CB3BEABD0

FASTA36438,352
        10         20         30         40         50         60 
MMDPGKSPGG QLGNHGITYA STGVDIEAGD RSVELFKPMA VKAIRTEVLG GLGGFAGLFA 

        70         80         90        100        110        120 
LRSGYREPVL AASTDGVGTK LAVAQAMDKH DTVGLDLVAM VVDDLVVCGA EPLFLQDYIA 

       130        140        150        160        170        180 
VGRTVPERLS AIVDGIAEGC MLAGCALLGG ETAEHPGLME VDHYDIAATG VGVVEADDTL 

       190        200        210        220        230        240 
GPDRVKPGDV IIALRSSGLH SNGYSLARSV LLEIDRMNLA GYVEEFGRTL GEELLEPTRI 

       250        260        270        280        290        300 
YAKDCLALAA ETHVRTFCHV TGGGLAGNLQ RVIPHGLVAE VDRGTWTPAP VFAMIAQRGR 

       310        320        330        340        350        360 
VAREEMEKTF NMGVGMIAVV APEDTDRALA ILTARHLDCW VLGTVCKGSK VGPRAKLVGQ 


HPRF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL583924 Genomic DNA. Translation: CAC31160.1.
PIRH87184.
RefSeqNP_302446.1. NC_002677.1.

3D structure databases

HSSPHSSP built from PDB template 1CLI based on UniProtKB P08178.
ProteinModelPortalQ9CBC2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000027955; EBMYCP00000027561; EBMYCG00000027950.
GeneID908828.
GenomeReviewsGene locus ML2205 in contig AL450380_GR.
KEGGmle:ML2205.
NMPDRfig|272631.1.peg.1318.
PATRIC18058517. VBIMycLep78757_4177.

Organism-specific databases

LepromaML2205.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016383.
HOGENOMHBG531222.
OMAPENIPRV.
ProtClustDBPRK05385.

Family and domain databases

InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
KOK01933.
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR00878. PurM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9CBC2_MYCLE
AccessionPrimary (citable) accession number: Q9CBC2
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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