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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107Proton donorUniRule annotation1
Metal bindingi135MagnesiumUniRule annotation1
Metal bindingi162MagnesiumUniRule annotation1
Metal bindingi185MagnesiumUniRule annotation1
Active sitei209Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMenaquinone biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2482-MONOMER
UniPathwayiUPA00079
UPA01057; UER00165

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotation (EC:4.2.1.113UniRule annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:ML2268
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2268

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712781 – 334o-succinylbenzoate synthaseAdd BLAST334

Proteomic databases

PRIDEiQ9CBB2

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2268

Structurei

3D structure databases

ProteinModelPortaliQ9CBB2
SMRiQ9CBB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TCW Bacteria
COG4948 LUCA
HOGENOMiHOG000249513
KOiK02549
OMAiAGWGEFS
OrthoDBiPOG091H04PO

Family and domain databases

Gene3Di3.20.20.120, 1 hit
3.30.390.10, 2 hits
HAMAPiMF_00470 MenC_1, 1 hit
InterProiView protein in InterPro
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR029065 Enolase_C-like
IPR013342 Mandelate_racemase_C
IPR010196 OSB_synthase_MenC1
PfamiView protein in Pfam
PF13378 MR_MLE_C, 1 hit
SMARTiView protein in SMART
SM00922 MR_MLE, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CBB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPTLTELLD RLHVVALPMR VRFRGITTRE VALIDGPAGW GEFGAFLEYQ
60 70 80 90 100
PLEASAWLVA GIEAAYGEPP EGRRDRIPIN ATVPAVSATQ VPEVLARFPG
110 120 130 140 150
VRTAKVKVAE PGQNLADDVD RVNAVRELVE TVRVDANGGW SVEAAAQAAV
160 170 180 190 200
ALTADGPLEY LEQPCATVAE LAALRRRVDI PIAADESIRK ADDPLAVVRS
210 220 230 240 250
HAADVAVLKV APLGGIASFL AIAAQIDIPV VVSSALDSVV GITAGLIAAA
260 270 280 290 300
ALPELDYACG LGTGRLFVAD VAEPMLPVDG FLPVGPVTPD PARLQALGTP
310 320 330
PARRQWWIDR VKTCYSLLVP CAGDQSGLRR PRDR
Length:334
Mass (Da):35,311
Last modified:June 1, 2001 - v1
Checksum:i9590196DACF93145
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA Translation: CAC31784.1
PIRiH87192
RefSeqiNP_302476.1, NC_002677.1
WP_010908796.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31784; CAC31784; CAC31784
GeneIDi908756
KEGGimle:ML2268
PATRICifig|272631.5.peg.4339

Similar proteinsi

Entry informationi

Entry nameiMENC_MYCLE
AccessioniPrimary (citable) accession number: Q9CBB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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