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Protein

Protease HtpX homolog

Gene

htpX

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi135Zinc; catalyticUniRule annotation1
Active sitei136UniRule annotation1
Metal bindingi139Zinc; catalyticUniRule annotation1
Metal bindingi206Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM48.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease HtpX homologUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:htpXUniRule annotation
Ordered Locus Names:ML2278
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2278.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalUniRule annotationAdd BLAST21
Transmembranei33 – 53HelicalUniRule annotationAdd BLAST21
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei181 – 201HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001388741 – 287Protease HtpX homologAdd BLAST287

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2278.

Structurei

3D structure databases

ProteinModelPortaliQ9CBA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D0M. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000227301.
KOiK03799.
OMAiSRYREYV.
OrthoDBiPOG091H01BW.

Family and domain databases

HAMAPiMF_00188. Pept_M48_protease_HtpX. 1 hit.
InterProiView protein in InterPro
IPR022919. Pept_M48_protease_HtpX.
IPR001915. Peptidase_M48.
PfamiView protein in Pfam
PF01435. Peptidase_M48. 1 hit.
PROSITEiView protein in PROSITE
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CBA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWHPQANRL KTFVLLVGMS TLIVVVGAIF GRTALFFATL VAVGINVYTY
60 70 80 90 100
YNSDKLALRA MHAQPVSEVQ APVMYRIVRE LATGAHQPMP RLYISDTNAP
110 120 130 140 150
NAFATGRNPR NAAVCCTTGI LEILNERELR AVLGHELSHV YNRDILISCV
160 170 180 190 200
AGALAGVITA LANMAMWAGT FGTTRDEENP FALLLVSLLG PIAATVVRLA
210 220 230 240 250
VSRSREYQAD ESGAMLTGDP LALASALRKI SSGVQAAPLP PEPQLASQAH
260 270 280
LMIANPFRVG DRIGSLFSTH PPIEDRIRRL ETMVAGR
Length:287
Mass (Da):30,998
Last modified:June 1, 2001 - v1
Checksum:i073DF0E8EAE70158
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA. Translation: CAC31794.1.
PIRiB87194.
RefSeqiNP_302484.1. NC_002677.1.
WP_010908804.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31794; CAC31794; CAC31794.
GeneIDi908742.
KEGGimle:ML2278.
PATRICifig|272631.5.peg.4352.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHTPX_MYCLE
AccessioniPrimary (citable) accession number: Q9CBA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families