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Q9CB92 (END3_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endonuclease III

EC=4.2.99.18
Alternative name(s):
DNA-(apurinic or apyrimidinic site) lyase
Gene names
Name:nth
Ordered Locus Names:ML2301
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate By similarity. HAMAP-Rule MF_00942

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00942

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP-Rule MF_00942

Sequence similarities

Belongs to the Nth/MutY family.

Contains 1 HhH domain.

Sequence caution

The sequence CAC31817.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Endonuclease III HAMAP-Rule MF_00942
PRO_0000102218

Regions

Domain119 – 13820HhH

Sites

Metal binding1981Iron-sulfur (4Fe-4S) By similarity
Metal binding2051Iron-sulfur (4Fe-4S) By similarity
Metal binding2081Iron-sulfur (4Fe-4S) By similarity
Metal binding2141Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CB92 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 1BF86C45306395D2

FASTA24527,194
        10         20         30         40         50         60 
MARRWSGETR LGLVRRARRM NRALAQAFPH VYCELDFTSP LELTVATILS AQSTDKRVNL 

        70         80         90        100        110        120 
TTPAVFARYR SALDYMQADR AELENFIRPT GFFRNKAASL IRLGQALVER FDGEVPSTMV 

       130        140        150        160        170        180 
DLFTLPGVGR KTANVILGNA FGIPGITVDT HFGRLVRRWR WTAEEDPVKV EHAVGELIER 

       190        200        210        220        230        240 
DQWTLLSHRV IFHGRRVCHA RKPACGVCVL AKDCPSFGLG PTEPLLAAPL VQGPEAGHLL 


ALAGL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583925 Genomic DNA. Translation: CAC31817.1. Different initiation.
PIRA87197.
RefSeqNP_302496.1. NC_002677.1.

3D structure databases

ProteinModelPortalQ9CB92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML2301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31817; CAC31817; CAC31817.
GeneID908145.
KEGGmle:ML2301.
PATRIC18058989. VBIMycLep78757_4411.

Organism-specific databases

LepromaML2301.
CMRSearch...

Phylogenomic databases

eggNOGCOG0177.
HOGENOMHOG000252208.
KOK10773.
OrthoDBEOG6H4KC5.

Family and domain databases

Gene3D1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPMF_00942. Nth.
InterProIPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR004035. Endouclease-III_FeS-bd_BS.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR023170. HTH_base_excis_C.
IPR005759. Nth.
[Graphical view]
PfamPF10576. EndIII_4Fe-2S. 1 hit.
PF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF001435. Nth. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
TIGRFAMsTIGR01083. nth. 1 hit.
PROSITEPS00764. ENDONUCLEASE_III_1. 1 hit.
PS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEND3_MYCLE
AccessionPrimary (citable) accession number: Q9CB92
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: May 14, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families