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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.

Cofactori

FADBy similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177By similarity1
Active sitei260Proton donorBy similarity1
Active sitei359By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-2682-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murB
Ordered Locus Names:ML2447
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2447

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792291 – 367UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST367

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2447

Structurei

3D structure databases

ProteinModelPortaliQ9CB48
SMRiQ9CB48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 205FAD-binding PCMH-typeAdd BLAST177

Sequence similaritiesi

Belongs to the MurB family.Curated

Phylogenomic databases

eggNOGiENOG4107R4N Bacteria
COG0812 LUCA
HOGENOMiHOG000284356
KOiK00075
OMAiAWLIDKA
OrthoDBiPOG091H02K7

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CB48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSAVGSFF AGAHVAEAVS LAPLTTLRVG PVAQRVITCA STEQVVDVIR
60 70 80 90 100
QLDAPAGGRG AGPLLIFAGG SNLVIADTLA DLTAVRLANA GITIDGNLVR
110 120 130 140 150
AEAGAVWDDV VVRAIEHGLG GLECLSGIPG SAGATPVQNV GAYGAEVSDT
160 170 180 190 200
ITRVRLLERS SGSVRWVSAC ELRFGYRTSV FKQADPSGSQ PPAVVLEVEF
210 220 230 240 250
KLDASGQSAP LHYGELVATL DATSGQRANP HAVREAVLAL RVRKGMVLDA
260 270 280 290 300
ADHDTWSVGS FFTNPVVAPD VYRQLAKMVD GPVPHYPAQD GVKLAAGWLV
310 320 330 340 350
ERAGFGKGYP DGAAPCRLST KHVLALTNRG AATAEDVVTL ARTVRNGVLE
360
VFGITLEPEP ALVGCVL
Length:367
Mass (Da):38,112
Last modified:June 1, 2001 - v1
Checksum:iA29D55EFD84921DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA Translation: CAC31964.1
PIRiD87215
RefSeqiNP_302586.1, NC_002677.1
WP_010908905.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31964; CAC31964; CAC31964
GeneIDi908302
KEGGimle:ML2447
PATRICifig|272631.5.peg.4701

Similar proteinsi

Entry informationi

Entry nameiMURB_MYCLE
AccessioniPrimary (citable) accession number: Q9CB48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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