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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.

Cofactori

FADBy similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771By similarity
Active sitei260 – 2601Proton donorBy similarity
Active sitei359 – 3591By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murB
Ordered Locus Names:ML2447
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2447.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367UDP-N-acetylenolpyruvoylglucosamine reductasePRO_0000179229Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2447.

Structurei

3D structure databases

ProteinModelPortaliQ9CB48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 205177FAD-binding PCMH-typeAdd
BLAST

Sequence similaritiesi

Belongs to the MurB family.Curated
Contains 1 FAD-binding PCMH-type domain.Curated

Phylogenomic databases

eggNOGiENOG4107R4N. Bacteria.
COG0812. LUCA.
HOGENOMiHOG000284356.
KOiK00075.
OMAiMQNIGAY.
OrthoDBiPOG091H02K7.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CB48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSAVGSFF AGAHVAEAVS LAPLTTLRVG PVAQRVITCA STEQVVDVIR
60 70 80 90 100
QLDAPAGGRG AGPLLIFAGG SNLVIADTLA DLTAVRLANA GITIDGNLVR
110 120 130 140 150
AEAGAVWDDV VVRAIEHGLG GLECLSGIPG SAGATPVQNV GAYGAEVSDT
160 170 180 190 200
ITRVRLLERS SGSVRWVSAC ELRFGYRTSV FKQADPSGSQ PPAVVLEVEF
210 220 230 240 250
KLDASGQSAP LHYGELVATL DATSGQRANP HAVREAVLAL RVRKGMVLDA
260 270 280 290 300
ADHDTWSVGS FFTNPVVAPD VYRQLAKMVD GPVPHYPAQD GVKLAAGWLV
310 320 330 340 350
ERAGFGKGYP DGAAPCRLST KHVLALTNRG AATAEDVVTL ARTVRNGVLE
360
VFGITLEPEP ALVGCVL
Length:367
Mass (Da):38,112
Last modified:June 1, 2001 - v1
Checksum:iA29D55EFD84921DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA. Translation: CAC31964.1.
PIRiD87215.
RefSeqiNP_302586.1. NC_002677.1.
WP_010908905.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31964; CAC31964; CAC31964.
GeneIDi908302.
KEGGimle:ML2447.
PATRICi18059573. VBIMycLep78757_4701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA. Translation: CAC31964.1.
PIRiD87215.
RefSeqiNP_302586.1. NC_002677.1.
WP_010908905.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CB48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31964; CAC31964; CAC31964.
GeneIDi908302.
KEGGimle:ML2447.
PATRICi18059573. VBIMycLep78757_4701.

Organism-specific databases

LepromaiML2447.

Phylogenomic databases

eggNOGiENOG4107R4N. Bacteria.
COG0812. LUCA.
HOGENOMiHOG000284356.
KOiK00075.
OMAiMQNIGAY.
OrthoDBiPOG091H02K7.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURB_MYCLE
AccessioniPrimary (citable) accession number: Q9CB48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.