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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611Schiff-base intermediate with acetaldehydeBy similarity
Active sitei191 – 1911By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase (EC:4.1.2.4)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:deoC
Ordered Locus Names:ML2451
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2451.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Deoxyribose-phosphate aldolasePRO_0000057247Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2451.

Structurei

3D structure databases

ProteinModelPortaliQ9CB45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241645.
KOiK01619.
OMAiGGDWDYV.
OrthoDBiEOG6QZMW5.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CB45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGQPTRKQL AALVDHTLLK SEATHADVAA LVAEAVELGV YAVCVSPSMV
60 70 80 90 100
PAAVEAGAGG LRVATVVGFP SGEHVSIVKA QEAVQAVASG ATEIDMVIAV
110 120 130 140 150
GAALAGDLDA VRSDIEMVRS AIAGVVLKVI VESAVLLGQA NERTLAEVCH
160 170 180 190 200
VAEAAGADFV KTSTGFHPAG GASVRAVTLM TEAVGGRLGV KASGGIRTAV
210 220
DAIALLDAGA TRLGLSSTRE VLDGLS
Length:226
Mass (Da):22,527
Last modified:April 27, 2001 - v1
Checksum:i2B79A2D09B84F8A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA. Translation: CAC31968.1.
PIRiH87215.
RefSeqiNP_302589.1. NC_002677.1.
WP_010908908.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31968; CAC31968; CAC31968.
GeneIDi908530.
KEGGimle:ML2451.
PATRICi18059581. VBIMycLep78757_4705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA. Translation: CAC31968.1.
PIRiH87215.
RefSeqiNP_302589.1. NC_002677.1.
WP_010908908.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CB45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31968; CAC31968; CAC31968.
GeneIDi908530.
KEGGimle:ML2451.
PATRICi18059581. VBIMycLep78757_4705.

Organism-specific databases

LepromaiML2451.

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241645.
KOiK01619.
OMAiGGDWDYV.
OrthoDBiEOG6QZMW5.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiDEOC_MYCLE
AccessioniPrimary (citable) accession number: Q9CB45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.