Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein GrpE

Gene

grpE

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:ML2495
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2495.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Protein GrpEPRO_0000113823Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML2495.

Structurei

3D structure databases

ProteinModelPortaliQ9CB23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108093. Bacteria.
COG0576. LUCA.
HOGENOMiHOG000252083.
KOiK03687.
OMAiDKRKIDP.
OrthoDBiPOG091H00J8.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CB23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEGNPHEQV TVTDKRRIDP DTGEVRSIPL GDTPGGSEPA GMTDRSANST
60 70 80 90 100
DTMVDKVAEL TSDLQRVQAD FANYRKRALR DQQTASDRAK ATVISQLLGV
110 120 130 140 150
LDDFDRAREH GDLDSGPLKS VADKLMSALT GLGLVAFGVE GEDFDPVLHE
160 170 180 190 200
AVQHEGDGGE GSKPVIGDVL RHGYKLGDQV LRHALVGVVD TIAGDGAETV
210 220
AIVAPVDSTA KTEQGELGDN VTPHKEDGD
Length:229
Mass (Da):24,248
Last modified:June 1, 2001 - v1
Checksum:iAD1F15FB309EAD48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA. Translation: CAC32012.1.
PIRiD87221.
RefSeqiNP_302612.1. NC_002677.1.
WP_010908931.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC32012; CAC32012; CAC32012.
GeneIDi908465.
KEGGimle:ML2495.
PATRICi18059751. VBIMycLep78757_4790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583925 Genomic DNA. Translation: CAC32012.1.
PIRiD87221.
RefSeqiNP_302612.1. NC_002677.1.
WP_010908931.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ9CB23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2495.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC32012; CAC32012; CAC32012.
GeneIDi908465.
KEGGimle:ML2495.
PATRICi18059751. VBIMycLep78757_4790.

Organism-specific databases

LepromaiML2495.

Phylogenomic databases

eggNOGiENOG4108093. Bacteria.
COG0576. LUCA.
HOGENOMiHOG000252083.
KOiK03687.
OMAiDKRKIDP.
OrthoDBiPOG091H00J8.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE_MYCLE
AccessioniPrimary (citable) accession number: Q9CB23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.