Q9CB17 (DCD_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	ML2507

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_0000155996

Sequences

	Sequence		Length	Mass (Da)
	Q9CB17 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1CA936700500B6FA	FASTA	190	20,821
	10 20 30 40 50 60 MLLSDRDLRA EITAGRFSID PFDDTLVQPS SIDVRLDCMF RVFNNTRYTH IDPARQQDEL 70 80 90 100 110 120 TSLVELVDGE PFVLHPGGFV LGSTLELFTL PEDLAGRLEG KSSLGRLGLL THSTAGFIDP 130 140 150 160 170 180 GFCGHITLEL SNVANLPITL WPGMKIGQLC VLRLTSPAEH PYGSASAGSK YQGQRGPTPS 190 RSYENFIKNT

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL583925 Genomic DNA. Translation: CAC32024.1.
PIR	H87222.
RefSeq	NP_302619.1. NC_002677.1.
3D structure databases
ProteinModelPortal	Q9CB17.
SMR	Q9CB17. Positions 1-189.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000028314; EBMYCP00000027920; EBMYCG00000028309.
GeneID	910802.
GenomeReviews	Gene locus ML2507 in contig AL450380_GR.
KEGG	mle:ML2507.
NMPDR	fig|272631.1.peg.1491.
PATRIC	18059801. VBIMycLep78757_4815.
Organism-specific databases
Leproma	ML2507.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016475.
HOGENOM	HBG553199.
OMA	MEYFRIP.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	MLEP272631:ML2507-MONOMER.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
KO	K01494.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_MYCLE

Accession

Primary (citable) accession number: Q9CB17

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program