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Protein

Organic cation/carnitine transporter 1

Gene

OCT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity carnitine transporter involved in the active cellular uptake of carnitine. Also transports organic cations. Regulates lateral root development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 220ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • cadaverine transport Source: TAIR
  • leaf senescence Source: TAIR

Keywordsi

Molecular functionDevelopmental protein
Biological processIon transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-112311. Neurotransmitter clearance.
R-ATH-181430. Norepinephrine Neurotransmitter Release Cycle.
R-ATH-197264. Nicotinamide salvaging.
R-ATH-200425. Import of palmitoyl-CoA into the mitochondrial matrix.
R-ATH-2161517. Abacavir transmembrane transport.
R-ATH-442660. Na+/Cl- dependent neurotransmitter transporters.
R-ATH-549127. Organic cation transport.
R-ATH-561048. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.13. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Organic cation/carnitine transporter 1
Short name:
AtOCT1
Gene namesi
Name:OCT1
Synonyms:1-Oct
Ordered Locus Names:At1g73220
ORF Names:T18K17.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G73220.
TAIRilocus:2197244. AT1G73220.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini74 – 133ExtracellularSequence analysisAdd BLAST60
Transmembranei134 – 154Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini155 – 172CytoplasmicSequence analysisAdd BLAST18
Transmembranei173 – 193Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini194 – 195ExtracellularSequence analysis2
Transmembranei196 – 218Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini219 – 224CytoplasmicSequence analysis6
Transmembranei225 – 245Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini246 – 256ExtracellularSequence analysisAdd BLAST11
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 336CytoplasmicSequence analysisAdd BLAST59
Transmembranei337 – 357Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini358 – 368ExtracellularSequence analysisAdd BLAST11
Transmembranei369 – 389Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini390 – 394CytoplasmicSequence analysis5
Transmembranei395 – 415Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini416 – 434ExtracellularSequence analysisAdd BLAST19
Transmembranei435 – 455Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini456 – 463CytoplasmicSequence analysis8
Transmembranei464 – 484Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini485 – 489ExtracellularSequence analysis5
Transmembranei490 – 510Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini511 – 539CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced sensitivity to carnitine and high degree of root branching.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004153571 – 539Organic cation/carnitine transporter 1Add BLAST539

Proteomic databases

PaxDbiQ9CAT6.
PRIDEiQ9CAT6.

Expressioni

Tissue specificityi

Expressed in vascular tissues and at sites of lateral root formation. Mostly present in floral buds, flowers and immature siliques.1 Publication

Developmental stagei

In flowers, expressed in anthers, sepals, petals and peduncles. Accumulates during germination in embryos, reaching a maximum during the radicle emergence. In seedlings, restricted to the vasculature, with highest levels in the collar and the root. Later present in both elongation and root hair zones in roots. Also present in root cap columella. Detected before and during lateral root initiation and emergence and thereafter remained in vascular tissues of each lateral root.1 Publication

Inductioni

Accumulates in embryo upon imbibition.1 Publication

Gene expression databases

ExpressionAtlasiQ9CAT6. baseline and differential.
GenevisibleiQ9CAT6. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G73220.1.

Structurei

3D structure databases

ProteinModelPortaliQ9CAT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000234568.
InParanoidiQ9CAT6.
OMAiGMKSRTW.
OrthoDBiEOG093607P5.
PhylomeDBiQ9CAT6.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR036259. MFS_trans_sf.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CAT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSKQEVPK LMETPPNISN DSSATEKGEA TRQQQLPNNR YALTVDEVIE
60 70 80 90 100
QHIGALGFAQ ILHALLVSIA WIFDAQTTLI SIFSDAQPAA RLLATGAIVE
110 120 130 140 150
GASLCGLASG EWEWIGPKSD TVVSEWNLIC QHKFLVAVPS TLFFIGSLFG
160 170 180 190 200
SGVYGYLADS WFGRKKTLLL SCVLTFVTAF AISFSPNVWV YAFLRFANGF
210 220 230 240 250
FRSGIGSCCI VLATEIVGKK WRGQVGQYGF FFFTLGFLSL PLMAYLERKS
260 270 280 290 300
WRNLYRIISF LPLGYAVCLL PFAYESPRWL LVKGRNKEAM VVLKKLARLN
310 320 330 340 350
GKQLPADLSL VDPIPERDDQ TSSSEKFWKT KWAVKRIIMV MMAGFGSGFV
360 370 380 390 400
YYGIQLNAEN LNFNLYLTVA VNALMEFPAV FIGSFLLGVM NRRPLFSNSS
410 420 430 440 450
YLAGFACLLC AVLSIHRVIR AISVAKWLQL AVEAVGFMAS STAYDVLYVY
460 470 480 490 500
CVELFPTNVR NTAVSLLRQA FMLGASAAPL LVALGRESAM MSFIVFGVAS
510 520 530
VLSGIVSLWL RETRNAPLYE TLAQQGKAEE IENETIMIT
Length:539
Mass (Da):59,660
Last modified:June 1, 2001 - v1
Checksum:i746096B8EBED653B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010556 Genomic DNA. Translation: AAG52125.1.
CP002684 Genomic DNA. Translation: AEE35431.1.
BT002455 mRNA. Translation: AAO00815.1.
BT008894 mRNA. Translation: AAP68333.1.
AY087932 mRNA. Translation: AAM67370.1.
PIRiC96758.
RefSeqiNP_565059.2. NM_105981.4.
UniGeneiAt.48369.
At.71027.

Genome annotation databases

EnsemblPlantsiAT1G73220.1; AT1G73220.1; AT1G73220.
GeneIDi843656.
GrameneiAT1G73220.1; AT1G73220.1; AT1G73220.
KEGGiath:AT1G73220.

Similar proteinsi

Entry informationi

Entry nameiOCT1_ARATH
AccessioniPrimary (citable) accession number: Q9CAT6
Secondary accession number(s): Q8LAB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families