Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Organic cation/carnitine transporter 1

Gene

OCT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity carnitine transporter involved in the active cellular uptake of carnitine. Also transports organic cations. Regulates lateral root development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 220ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • carnitine transmembrane transporter activity Source: TAIR

GO - Biological processi

  • cadaverine transport Source: TAIR
  • leaf senescence Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-112311. Neurotransmitter Clearance In The Synaptic Cleft.
R-ATH-181430. Norepinephrine Neurotransmitter Release Cycle.
R-ATH-2161517. Abacavir transmembrane transport.
R-ATH-442660. Na+/Cl- dependent neurotransmitter transporters.
R-ATH-549127. Organic cation transport.

Protein family/group databases

TCDBi2.A.1.19.13. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Organic cation/carnitine transporter 1
Short name:
AtOCT1
Gene namesi
Name:OCT1
Synonyms:1-Oct
Ordered Locus Names:At1g73220
ORF Names:T18K17.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G73220.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini74 – 133ExtracellularSequence analysisAdd BLAST60
Transmembranei134 – 154Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini155 – 172CytoplasmicSequence analysisAdd BLAST18
Transmembranei173 – 193Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini194 – 195ExtracellularSequence analysis2
Transmembranei196 – 218Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini219 – 224CytoplasmicSequence analysis6
Transmembranei225 – 245Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini246 – 256ExtracellularSequence analysisAdd BLAST11
Transmembranei257 – 277Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini278 – 336CytoplasmicSequence analysisAdd BLAST59
Transmembranei337 – 357Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini358 – 368ExtracellularSequence analysisAdd BLAST11
Transmembranei369 – 389Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini390 – 394CytoplasmicSequence analysis5
Transmembranei395 – 415Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini416 – 434ExtracellularSequence analysisAdd BLAST19
Transmembranei435 – 455Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini456 – 463CytoplasmicSequence analysis8
Transmembranei464 – 484Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini485 – 489ExtracellularSequence analysis5
Transmembranei490 – 510Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini511 – 539CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced sensitivity to carnitine and high degree of root branching.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004153571 – 539Organic cation/carnitine transporter 1Add BLAST539

Proteomic databases

PaxDbiQ9CAT6.
PRIDEiQ9CAT6.

Expressioni

Tissue specificityi

Expressed in vascular tissues and at sites of lateral root formation. Mostly present in floral buds, flowers and immature siliques.1 Publication

Developmental stagei

In flowers, expressed in anthers, sepals, petals and peduncles. Accumulates during germination in embryos, reaching a maximum during the radicle emergence. In seedlings, restricted to the vasculature, with highest levels in the collar and the root. Later present in both elongation and root hair zones in roots. Also present in root cap columella. Detected before and during lateral root initiation and emergence and thereafter remained in vascular tissues of each lateral root.1 Publication

Inductioni

Accumulates in embryo upon imbibition.1 Publication

Gene expression databases

GenevisibleiQ9CAT6. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G73220.1.

Structurei

3D structure databases

ProteinModelPortaliQ9CAT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000234568.
InParanoidiQ9CAT6.
OMAiRNKEAMV.
OrthoDBiEOG093607P5.
PhylomeDBiQ9CAT6.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CAT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSKQEVPK LMETPPNISN DSSATEKGEA TRQQQLPNNR YALTVDEVIE
60 70 80 90 100
QHIGALGFAQ ILHALLVSIA WIFDAQTTLI SIFSDAQPAA RLLATGAIVE
110 120 130 140 150
GASLCGLASG EWEWIGPKSD TVVSEWNLIC QHKFLVAVPS TLFFIGSLFG
160 170 180 190 200
SGVYGYLADS WFGRKKTLLL SCVLTFVTAF AISFSPNVWV YAFLRFANGF
210 220 230 240 250
FRSGIGSCCI VLATEIVGKK WRGQVGQYGF FFFTLGFLSL PLMAYLERKS
260 270 280 290 300
WRNLYRIISF LPLGYAVCLL PFAYESPRWL LVKGRNKEAM VVLKKLARLN
310 320 330 340 350
GKQLPADLSL VDPIPERDDQ TSSSEKFWKT KWAVKRIIMV MMAGFGSGFV
360 370 380 390 400
YYGIQLNAEN LNFNLYLTVA VNALMEFPAV FIGSFLLGVM NRRPLFSNSS
410 420 430 440 450
YLAGFACLLC AVLSIHRVIR AISVAKWLQL AVEAVGFMAS STAYDVLYVY
460 470 480 490 500
CVELFPTNVR NTAVSLLRQA FMLGASAAPL LVALGRESAM MSFIVFGVAS
510 520 530
VLSGIVSLWL RETRNAPLYE TLAQQGKAEE IENETIMIT
Length:539
Mass (Da):59,660
Last modified:June 1, 2001 - v1
Checksum:i746096B8EBED653B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010556 Genomic DNA. Translation: AAG52125.1.
CP002684 Genomic DNA. Translation: AEE35431.1.
BT002455 mRNA. Translation: AAO00815.1.
BT008894 mRNA. Translation: AAP68333.1.
AY087932 mRNA. Translation: AAM67370.1.
PIRiC96758.
RefSeqiNP_565059.2. NM_105981.4.
UniGeneiAt.48369.
At.71027.

Genome annotation databases

EnsemblPlantsiAT1G73220.1; AT1G73220.1; AT1G73220.
GeneIDi843656.
GrameneiAT1G73220.1; AT1G73220.1; AT1G73220.
KEGGiath:AT1G73220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010556 Genomic DNA. Translation: AAG52125.1.
CP002684 Genomic DNA. Translation: AEE35431.1.
BT002455 mRNA. Translation: AAO00815.1.
BT008894 mRNA. Translation: AAP68333.1.
AY087932 mRNA. Translation: AAM67370.1.
PIRiC96758.
RefSeqiNP_565059.2. NM_105981.4.
UniGeneiAt.48369.
At.71027.

3D structure databases

ProteinModelPortaliQ9CAT6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G73220.1.

Protein family/group databases

TCDBi2.A.1.19.13. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiQ9CAT6.
PRIDEiQ9CAT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G73220.1; AT1G73220.1; AT1G73220.
GeneIDi843656.
GrameneiAT1G73220.1; AT1G73220.1; AT1G73220.
KEGGiath:AT1G73220.

Organism-specific databases

TAIRiAT1G73220.

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000234568.
InParanoidiQ9CAT6.
OMAiRNKEAMV.
OrthoDBiEOG093607P5.
PhylomeDBiQ9CAT6.

Enzyme and pathway databases

ReactomeiR-ATH-112311. Neurotransmitter Clearance In The Synaptic Cleft.
R-ATH-181430. Norepinephrine Neurotransmitter Release Cycle.
R-ATH-2161517. Abacavir transmembrane transport.
R-ATH-442660. Na+/Cl- dependent neurotransmitter transporters.
R-ATH-549127. Organic cation transport.

Miscellaneous databases

PROiQ9CAT6.

Gene expression databases

GenevisibleiQ9CAT6. AT.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOCT1_ARATH
AccessioniPrimary (citable) accession number: Q9CAT6
Secondary accession number(s): Q8LAB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.