Q9CAQ2 (Y1754_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyltransferase At1g77540
EC=2.3.1.-

Alternative name(s):
Minimal acetyltransferase

Gene names

Ordered Locus Names:	At1g77540
ORF Names:	T5M16.13

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possesses in vitro histone acetyltransferase activity with histones H3 and H4. Ref.5
Sequence caution	The sequence AAG51659.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	peroxisome Inferred from direct assay PubMed 19329564. Source: TAIR
Molecular_function	histone acetyltransferase activity Inferred from direct assay Ref.5. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 114

114

Acetyltransferase At1g77540

PRO_0000220598

Regions

Region

52 – 55

4

Coenzyme A binding

Region

61 – 66

6

Coenzyme A binding

Region

88 – 89

2

Coenzyme A binding

Sites

Active site

87

1

Nucleophile Potential

Binding site

93

1

Coenzyme A

Binding site

97

1

Coenzyme A

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

114

Helix Strand Turn

Details...

Beta strand

19 – 22

4

Helix

23 – 25

3

Beta strand

27 – 30

4

Beta strand

33 – 42

10

Turn

43 – 46

4

Beta strand

47 – 54

8

Helix

57 – 59

3

Helix

64 – 78

15

Beta strand

82 – 85

4

Helix

88 – 92

5

Helix

94 – 97

4

Helix

99 – 104

6

Beta strand

105 – 110

6

Sequences

	Sequence		Length	Mass (Da)
	Q9CAQ2 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: DB18B8D8DC7C8F26	FASTA	114	12,855
	10 20 30 40 50 60 MTNTAATTEA KMATEPPKIV WNEGKRRFET EDHEAFIEYK MRNNGKVMDL VHTYVPSFKR 70 80 90 100 110 GLGLASHLCV AAFEHASSHS ISIIPSCSYV SDTFLPRNPS WKPLIHSEVF KSSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Arabidopsis ORF clones." Shinn P., Chen H., Kim C.J., Ecker J.R. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Structure of Arabidopsis thaliana At1g77540 protein, a minimal acetyltransferase from the COG2388 family." Tyler R.C., Bitto E., Berndsen C.E., Bingman C.A., Singh S., Lee M.S., Wesenberg G.E., Denu J.M., Phillips G.N. Jr., Markley J.L. Biochemistry 45:14325-14336(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF 12-114 IN COMPLEX WITH COENZYME A, FUNCTION.
[6]	"Ensemble refinement of protein crystal structures: validation and application." Levin E.J., Kondrashov D.A., Wesenberg G.E., Phillips G.N. Jr. Structure 15:1040-1052(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF 12-114 IN COMPLEX WITH COENZYME A.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC010704 Genomic DNA. Translation: AAG51659.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE35991.1.
BT024548 mRNA. Translation: ABD38887.1.
AY085337 mRNA. Translation: AAM62568.1.

IPI

IPI00524037.

PIR

H96804.

RefSeq

NP_565157.1. NM_106403.3.

UniGene

At.34458.
At.75659.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XMT	X-ray	1.15	A	13-114	[»]
2EVN	NMR	-	A	12-114	[»]
2IL4	X-ray	2.05	A	12-114	[»]
2Q44	X-ray	1.15	A	13-114	[»]
2Q4Y	X-ray	2.06	A	12-114	[»]

ProteinModelPortal

Q9CAQ2.

SMR

Q9CAQ2. Positions 16-110.

ModBase

Search...

Protein-protein interaction databases

STRING

3702.AT1G77540.1-P.

Proteomic databases

PaxDb

Q9CAQ2.

PRIDE

Q9CAQ2.

Protocols and materials databases

DNASU

844090.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblPlants

AT1G77540.1; AT1G77540.1; AT1G77540.

GeneID

844090.

KEGG

ath:AT1G77540.

Organism-specific databases

TAIR

At1g77540.

Phylogenomic databases

eggNOG

NOG311025.

HOGENOM

HOG000167985.

InParanoid

Q9CAQ2.

OMA

ETESIVW.

PhylomeDB

Q9CAQ2.

ProtClustDB

CLSN2687902.

Gene expression databases

Genevestigator

Q9CAQ2.

GermOnline

AT1G77540. Arabidopsis thaliana.

Family and domain databases

Gene3D

3.40.630.30. 1 hit.

InterPro

IPR016181. Acyl_CoA_acyltransferase.
[Graphical view]

SUPFAM

SSF55729. Acyl_CoA_acyltransferase. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q9CAQ2.

Entry information

Entry name

Y1754_ARATH

Accession

Primary (citable) accession number: Q9CAQ2
Secondary accession number(s): Q2HIN3, Q8LEN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program