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Protein

Developmentally-regulated G-protein 2

Gene

DRG2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds GDP and GTP, and has low GTPase activity.1 Publication

Caution

The nomenclature of the 3 Arabidopsis DRG genes is ambiguous; in the literature several gene names have been used for the same protein.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76GTPPROSITE-ProRule annotation8
Nucleotide bindingi115 – 119GTPPROSITE-ProRule annotation5
Nucleotide bindingi246 – 249GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated G-protein 2
Short name:
AtDRG2
Alternative name(s):
Developmentally-regulated G-protein 2B
Short name:
AtDRG2b
Gene namesi
Name:DRG2
Synonyms:DRG2B
Ordered Locus Names:At1g72660
ORF Names:F28P22.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G72660
TAIRilocus:2030240 AT1G72660

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004126091 – 399Developmentally-regulated G-protein 2Add BLAST399

Proteomic databases

PaxDbiQ9CAI1
PRIDEiQ9CAI1

Expressioni

Gene expression databases

ExpressionAtlasiQ9CAI1 baseline and differential
GenevisibleiQ9CAI1 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G72660.1

Structurei

3D structure databases

ProteinModelPortaliQ9CAI1
SMRiQ9CAI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 288OBG-type GPROSITE-ProRule annotationAdd BLAST226

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 183Poly-Lys4

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1486 Eukaryota
COG1163 LUCA
HOGENOMiHOG000112078
InParanoidiQ9CAI1
KOiK06944
OMAiMIREDIT
OrthoDBiEOG09360CXC
PhylomeDBiQ9CAI1

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CAI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIVERIKEI EAEMARTQKN KATEYHLGQL KAKIAKLRTQ LLEPPKGSSG
60 70 80 90 100
GGDGFEVTKY GHGRVALIGF PSVGKSTLLT MLTGTHSEAA SYEFTTLTCI
110 120 130 140 150
PGVIHYNDTK IQLLDLPGII EGASEGKGRG RQVIAVAKSS DLVLMVLDAS
160 170 180 190 200
KSEGHRQILT KELEAVGLRL NKRPPQIYFK KKKTGGISFN TTTPLTRIDE
210 220 230 240 250
KLCYQILHEY KIHNAEVLFR EDATVDDFID VVEGNRKYIK CVYVYNKIDV
260 270 280 290 300
VGIDDVDRLA RQPNSIVISC NLKLNLDRLL ARMWDEMGLV RVYSKPQSQQ
310 320 330 340 350
PDFDEPFVLS ADRGGCTVED FCNQVHRTLV KDMKYALVWG TSARHYPQHC
360 370 380 390
GLFHHLEDED VVQIVKKKVR EEGGRGRFKS HSNAPARIAD REKKAPLKQ
Length:399
Mass (Da):44,803
Last modified:June 1, 2001 - v1
Checksum:i15BFEE07552B19CE
GO
Isoform 2 (identifier: Q9CAI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):29,412
Checksum:i1B5E3A2CBDD1F4FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296P → R in BAD95228 (Ref. 6) Curated1
Sequence conflicti304D → G in BAD95228 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0417221 – 144Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA Translation: AAG51856.1
CP002684 Genomic DNA Translation: AEE35356.1
CP002684 Genomic DNA Translation: AEE35357.1
CP002684 Genomic DNA Translation: AEE35358.1
AK118905 mRNA Translation: BAC43489.1
BT006031 mRNA Translation: AAP04018.1
AK319004 mRNA Translation: BAH57119.1
AK221170 mRNA Translation: BAD95228.1
PIRiC96751
RefSeqiNP_001031270.1, NM_001036193.2 [Q9CAI1-1]
NP_001031271.1, NM_001036194.1 [Q9CAI1-1]
NP_177410.1, NM_105925.4 [Q9CAI1-1]
UniGeneiAt.35074

Genome annotation databases

EnsemblPlantsiAT1G72660.1; AT1G72660.1; AT1G72660 [Q9CAI1-1]
AT1G72660.2; AT1G72660.2; AT1G72660 [Q9CAI1-1]
AT1G72660.3; AT1G72660.3; AT1G72660 [Q9CAI1-1]
GeneIDi843598
GrameneiAT1G72660.1; AT1G72660.1; AT1G72660 [Q9CAI1-1]
AT1G72660.2; AT1G72660.2; AT1G72660 [Q9CAI1-1]
AT1G72660.3; AT1G72660.3; AT1G72660 [Q9CAI1-1]
KEGGiath:AT1G72660

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDRG2_ARATH
AccessioniPrimary (citable) accession number: Q9CAI1
Secondary accession number(s): C0Z340, Q56Z00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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