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Protein

Developmentally-regulated G-protein 2

Gene

DRG2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds GDP and GTP, and has low GTPase activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 76GTPPROSITE-ProRule annotation8
Nucleotide bindingi115 – 119GTPPROSITE-ProRule annotation5
Nucleotide bindingi246 – 249GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated G-protein 2
Short name:
AtDRG2
Alternative name(s):
Developmentally-regulated G-protein 2B
Short name:
AtDRG2b
Gene namesi
Name:DRG2
Synonyms:DRG2B
Ordered Locus Names:At1g72660
ORF Names:F28P22.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G72660.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004126091 – 399Developmentally-regulated G-protein 2Add BLAST399

Proteomic databases

PaxDbiQ9CAI1.

Expressioni

Gene expression databases

GenevisibleiQ9CAI1. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G72660.1.

Structurei

3D structure databases

ProteinModelPortaliQ9CAI1.
SMRiQ9CAI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 288OBG-type GPROSITE-ProRule annotationAdd BLAST226

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 183Poly-Lys4

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1486. Eukaryota.
COG1163. LUCA.
HOGENOMiHOG000112078.
InParanoidiQ9CAI1.
OMAiVEGNRKY.
OrthoDBiEOG09360CXC.
PhylomeDBiQ9CAI1.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CAI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIVERIKEI EAEMARTQKN KATEYHLGQL KAKIAKLRTQ LLEPPKGSSG
60 70 80 90 100
GGDGFEVTKY GHGRVALIGF PSVGKSTLLT MLTGTHSEAA SYEFTTLTCI
110 120 130 140 150
PGVIHYNDTK IQLLDLPGII EGASEGKGRG RQVIAVAKSS DLVLMVLDAS
160 170 180 190 200
KSEGHRQILT KELEAVGLRL NKRPPQIYFK KKKTGGISFN TTTPLTRIDE
210 220 230 240 250
KLCYQILHEY KIHNAEVLFR EDATVDDFID VVEGNRKYIK CVYVYNKIDV
260 270 280 290 300
VGIDDVDRLA RQPNSIVISC NLKLNLDRLL ARMWDEMGLV RVYSKPQSQQ
310 320 330 340 350
PDFDEPFVLS ADRGGCTVED FCNQVHRTLV KDMKYALVWG TSARHYPQHC
360 370 380 390
GLFHHLEDED VVQIVKKKVR EEGGRGRFKS HSNAPARIAD REKKAPLKQ
Length:399
Mass (Da):44,803
Last modified:June 1, 2001 - v1
Checksum:i15BFEE07552B19CE
GO
Isoform 2 (identifier: Q9CAI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):29,412
Checksum:i1B5E3A2CBDD1F4FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296P → R in BAD95228 (Ref. 6) Curated1
Sequence conflicti304D → G in BAD95228 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0417221 – 144Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA. Translation: AAG51856.1.
CP002684 Genomic DNA. Translation: AEE35356.1.
CP002684 Genomic DNA. Translation: AEE35357.1.
CP002684 Genomic DNA. Translation: AEE35358.1.
AK118905 mRNA. Translation: BAC43489.1.
BT006031 mRNA. Translation: AAP04018.1.
AK319004 mRNA. Translation: BAH57119.1.
AK221170 mRNA. Translation: BAD95228.1.
PIRiC96751.
RefSeqiNP_001031270.1. NM_001036193.2. [Q9CAI1-1]
NP_001031271.1. NM_001036194.1. [Q9CAI1-1]
NP_177410.1. NM_105925.4. [Q9CAI1-1]
UniGeneiAt.35074.

Genome annotation databases

EnsemblPlantsiAT1G72660.1; AT1G72660.1; AT1G72660. [Q9CAI1-1]
AT1G72660.2; AT1G72660.2; AT1G72660. [Q9CAI1-1]
AT1G72660.3; AT1G72660.3; AT1G72660. [Q9CAI1-1]
GeneIDi843598.
GrameneiAT1G72660.1; AT1G72660.1; AT1G72660.
AT1G72660.2; AT1G72660.2; AT1G72660.
AT1G72660.3; AT1G72660.3; AT1G72660.
KEGGiath:AT1G72660.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA. Translation: AAG51856.1.
CP002684 Genomic DNA. Translation: AEE35356.1.
CP002684 Genomic DNA. Translation: AEE35357.1.
CP002684 Genomic DNA. Translation: AEE35358.1.
AK118905 mRNA. Translation: BAC43489.1.
BT006031 mRNA. Translation: AAP04018.1.
AK319004 mRNA. Translation: BAH57119.1.
AK221170 mRNA. Translation: BAD95228.1.
PIRiC96751.
RefSeqiNP_001031270.1. NM_001036193.2. [Q9CAI1-1]
NP_001031271.1. NM_001036194.1. [Q9CAI1-1]
NP_177410.1. NM_105925.4. [Q9CAI1-1]
UniGeneiAt.35074.

3D structure databases

ProteinModelPortaliQ9CAI1.
SMRiQ9CAI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G72660.1.

Proteomic databases

PaxDbiQ9CAI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G72660.1; AT1G72660.1; AT1G72660. [Q9CAI1-1]
AT1G72660.2; AT1G72660.2; AT1G72660. [Q9CAI1-1]
AT1G72660.3; AT1G72660.3; AT1G72660. [Q9CAI1-1]
GeneIDi843598.
GrameneiAT1G72660.1; AT1G72660.1; AT1G72660.
AT1G72660.2; AT1G72660.2; AT1G72660.
AT1G72660.3; AT1G72660.3; AT1G72660.
KEGGiath:AT1G72660.

Organism-specific databases

TAIRiAT1G72660.

Phylogenomic databases

eggNOGiKOG1486. Eukaryota.
COG1163. LUCA.
HOGENOMiHOG000112078.
InParanoidiQ9CAI1.
OMAiVEGNRKY.
OrthoDBiEOG09360CXC.
PhylomeDBiQ9CAI1.

Miscellaneous databases

PROiQ9CAI1.

Gene expression databases

GenevisibleiQ9CAI1. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRG2_ARATH
AccessioniPrimary (citable) accession number: Q9CAI1
Secondary accession number(s): C0Z340, Q56Z00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

The nomenclature of the 3 Arabidopsis DRG genes is ambiguous; in the literature several gene names have been used for the same protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.