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Q9CAH5

- POED1_ARATH

UniProt

Q9CAH5 - POED1_ARATH

Protein

Polyprenol reductase 1

Gene

At1g72590

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.By similarity

    Catalytic activityi

    Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: InterPro
    2. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_185286. Synthesis of Dolichyl-phosphate.
    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyprenol reductase 1 (EC:1.3.1.94)
    Gene namesi
    Ordered Locus Names:At1g72590
    ORF Names:F28P22.22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G72590.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Polyprenol reductase 1PRO_0000398655Add
    BLAST

    Proteomic databases

    PRIDEiQ9CAH5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9CAH5.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G72590.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CAH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330066.
    HOGENOMiHOG000240963.
    InParanoidiQ9CAH5.
    OMAiTHIRCED.
    PhylomeDBiQ9CAH5.

    Family and domain databases

    InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CAH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVEIVWLVK AAWITVWIVS ILPLVIASIP SSKLNSFREL VLSFAGRGKI    50
    LHPSSQKFTV PQKFFGHFYV VGVVWTTLLL AATWMYACKM AGGSHVFSFH 100
    MTHVEHRFKV GRAVFLLLLM EIHVLRRVIE SFYVFKYSTS ARMHILAYVG 150
    ALFYYVAAPL SLCSNIAPEV ARFVGSQVAE FIASGKSHSH DFNLLLSISP 200
    LMKLGSLQWI GGAIFLWGWI HQRRCHAILG SLREYPSQAK EYIIPYGDWF 250
    EMVSCPHFLA EIVLYLGLLI SSGGTDISIW LLFGFVAANL TYAAGETHRW 300
    YLQKFENYPA SRHAIFPHVY 320
    Length:320
    Mass (Da):36,313
    Last modified:June 1, 2001 - v1
    Checksum:i326E51CF4A5719E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010926 Genomic DNA. Translation: AAG51854.1.
    CP002684 Genomic DNA. Translation: AEE35345.1.
    PIRiD96750.
    RefSeqiNP_177403.1. NM_105918.2.
    UniGeneiAt.35081.

    Genome annotation databases

    EnsemblPlantsiAT1G72590.1; AT1G72590.1; AT1G72590.
    GeneIDi843591.
    KEGGiath:AT1G72590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010926 Genomic DNA. Translation: AAG51854.1 .
    CP002684 Genomic DNA. Translation: AEE35345.1 .
    PIRi D96750.
    RefSeqi NP_177403.1. NM_105918.2.
    UniGenei At.35081.

    3D structure databases

    ProteinModelPortali Q9CAH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G72590.1-P.

    Proteomic databases

    PRIDEi Q9CAH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G72590.1 ; AT1G72590.1 ; AT1G72590 .
    GeneIDi 843591.
    KEGGi ath:AT1G72590.

    Organism-specific databases

    TAIRi AT1G72590.

    Phylogenomic databases

    eggNOGi NOG330066.
    HOGENOMi HOG000240963.
    InParanoidi Q9CAH5.
    OMAi THIRCED.
    PhylomeDBi Q9CAH5.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_185286. Synthesis of Dolichyl-phosphate.

    Gene expression databases

    Genevestigatori Q9CAH5.

    Family and domain databases

    InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiPOED1_ARATH
    AccessioniPrimary (citable) accession number: Q9CAH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3