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Protein

Polyprenol reductase 1

Gene

PPRD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Involved in the regulation of plant growth and reproductive processes.1 Publication

Catalytic activityi

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: TAIR
  • polyprenol reductase activity Source: UniProtKB-EC

GO - Biological processi

  • polyprenol metabolic process Source: TAIR
  • protein glycosylation Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-ATH-193048 Androgen biosynthesis
R-ATH-446199 Synthesis of Dolichyl-phosphate
UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprenol reductase 11 Publication (EC:1.3.1.941 Publication)
Gene namesi
Name:PPRD11 Publication
Ordered Locus Names:At1g72590Imported
ORF Names:F28P22.22Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G72590
TAIRilocus:2030235 AT1G72590

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986551 – 320Polyprenol reductase 1Add BLAST320

Proteomic databases

PaxDbiQ9CAH5

Expressioni

Tissue specificityi

Expressed in roots and flowers.1 Publication

Gene expression databases

GenevisibleiQ9CAH5 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G72590.1

Structurei

3D structure databases

ProteinModelPortaliQ9CAH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1640 Eukaryota
ENOG4111JQM LUCA
HOGENOMiHOG000240963
InParanoidiQ9CAH5
OMAiRFNVWKS
OrthoDBiEOG09360J9J
PhylomeDBiQ9CAH5

Family and domain databases

InterProiView protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CAH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVEIVWLVK AAWITVWIVS ILPLVIASIP SSKLNSFREL VLSFAGRGKI
60 70 80 90 100
LHPSSQKFTV PQKFFGHFYV VGVVWTTLLL AATWMYACKM AGGSHVFSFH
110 120 130 140 150
MTHVEHRFKV GRAVFLLLLM EIHVLRRVIE SFYVFKYSTS ARMHILAYVG
160 170 180 190 200
ALFYYVAAPL SLCSNIAPEV ARFVGSQVAE FIASGKSHSH DFNLLLSISP
210 220 230 240 250
LMKLGSLQWI GGAIFLWGWI HQRRCHAILG SLREYPSQAK EYIIPYGDWF
260 270 280 290 300
EMVSCPHFLA EIVLYLGLLI SSGGTDISIW LLFGFVAANL TYAAGETHRW
310 320
YLQKFENYPA SRHAIFPHVY
Length:320
Mass (Da):36,313
Last modified:June 1, 2001 - v1
Checksum:i326E51CF4A5719E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010926 Genomic DNA Translation: AAG51854.1
CP002684 Genomic DNA Translation: AEE35345.1
PIRiD96750
RefSeqiNP_177403.1, NM_105918.3
UniGeneiAt.35081

Genome annotation databases

EnsemblPlantsiAT1G72590.1; AT1G72590.1; AT1G72590
GeneIDi843591
GrameneiAT1G72590.1; AT1G72590.1; AT1G72590
KEGGiath:AT1G72590

Similar proteinsi

Entry informationi

Entry nameiPOED1_ARATH
AccessioniPrimary (citable) accession number: Q9CAH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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