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Q9CAH5 (POED1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Polyprenol reductase 1

EC=1.3.1.94
Gene names
Ordered Locus Names:At1g72590
ORF Names:F28P22.22
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.

Catalytic activity

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Polyprenol reductase 1
PRO_0000398655

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane64 – 8421Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane266 – 28621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CAH5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 326E51CF4A5719E5

FASTA32036,313
        10         20         30         40         50         60 
MEVEIVWLVK AAWITVWIVS ILPLVIASIP SSKLNSFREL VLSFAGRGKI LHPSSQKFTV 

        70         80         90        100        110        120 
PQKFFGHFYV VGVVWTTLLL AATWMYACKM AGGSHVFSFH MTHVEHRFKV GRAVFLLLLM 

       130        140        150        160        170        180 
EIHVLRRVIE SFYVFKYSTS ARMHILAYVG ALFYYVAAPL SLCSNIAPEV ARFVGSQVAE 

       190        200        210        220        230        240 
FIASGKSHSH DFNLLLSISP LMKLGSLQWI GGAIFLWGWI HQRRCHAILG SLREYPSQAK 

       250        260        270        280        290        300 
EYIIPYGDWF EMVSCPHFLA EIVLYLGLLI SSGGTDISIW LLFGFVAANL TYAAGETHRW 

       310        320 
YLQKFENYPA SRHAIFPHVY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010926 Genomic DNA. Translation: AAG51854.1.
CP002684 Genomic DNA. Translation: AEE35345.1.
PIRD96750.
RefSeqNP_177403.1. NM_105918.2.
UniGeneAt.35081.

3D structure databases

ProteinModelPortalQ9CAH5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G72590.1-P.

Proteomic databases

PRIDEQ9CAH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G72590.1; AT1G72590.1; AT1G72590.
GeneID843591.
KEGGath:AT1G72590.

Organism-specific databases

TAIRAT1G72590.

Phylogenomic databases

eggNOGNOG330066.
HOGENOMHOG000240963.
InParanoidQ9CAH5.
OMASHIILAN.
PhylomeDBQ9CAH5.
ProtClustDBPLN03164.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

GenevestigatorQ9CAH5.

Family and domain databases

InterProIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOED1_ARATH
AccessionPrimary (citable) accession number: Q9CAH5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names