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Q9CAH5

- POED1_ARATH

UniProt

Q9CAH5 - POED1_ARATH

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Protein

Polyprenol reductase 1

Gene
At1g72590, F28P22.22
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.

Catalytic activityi

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

GO - Biological processi

  1. lipid metabolic process Source: InterPro
  2. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_185286. Synthesis of Dolichyl-phosphate.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprenol reductase 1 (EC:1.3.1.94)
Gene namesi
Ordered Locus Names:At1g72590
ORF Names:F28P22.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G72590.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Reviewed predictionAdd
BLAST
Transmembranei64 – 8421Helical; Reviewed predictionAdd
BLAST
Transmembranei143 – 16321Helical; Reviewed predictionAdd
BLAST
Transmembranei200 – 22021Helical; Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Transmembranei266 – 28621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Polyprenol reductase 1PRO_0000398655Add
BLAST

Proteomic databases

PRIDEiQ9CAH5.

Expressioni

Gene expression databases

GenevestigatoriQ9CAH5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G72590.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9CAH5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330066.
HOGENOMiHOG000240963.
InParanoidiQ9CAH5.
OMAiTHIRCED.
PhylomeDBiQ9CAH5.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CAH5-1 [UniParc]FASTAAdd to Basket

« Hide

MEVEIVWLVK AAWITVWIVS ILPLVIASIP SSKLNSFREL VLSFAGRGKI    50
LHPSSQKFTV PQKFFGHFYV VGVVWTTLLL AATWMYACKM AGGSHVFSFH 100
MTHVEHRFKV GRAVFLLLLM EIHVLRRVIE SFYVFKYSTS ARMHILAYVG 150
ALFYYVAAPL SLCSNIAPEV ARFVGSQVAE FIASGKSHSH DFNLLLSISP 200
LMKLGSLQWI GGAIFLWGWI HQRRCHAILG SLREYPSQAK EYIIPYGDWF 250
EMVSCPHFLA EIVLYLGLLI SSGGTDISIW LLFGFVAANL TYAAGETHRW 300
YLQKFENYPA SRHAIFPHVY 320
Length:320
Mass (Da):36,313
Last modified:June 1, 2001 - v1
Checksum:i326E51CF4A5719E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010926 Genomic DNA. Translation: AAG51854.1.
CP002684 Genomic DNA. Translation: AEE35345.1.
PIRiD96750.
RefSeqiNP_177403.1. NM_105918.2.
UniGeneiAt.35081.

Genome annotation databases

EnsemblPlantsiAT1G72590.1; AT1G72590.1; AT1G72590.
GeneIDi843591.
KEGGiath:AT1G72590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010926 Genomic DNA. Translation: AAG51854.1 .
CP002684 Genomic DNA. Translation: AEE35345.1 .
PIRi D96750.
RefSeqi NP_177403.1. NM_105918.2.
UniGenei At.35081.

3D structure databases

ProteinModelPortali Q9CAH5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G72590.1-P.

Proteomic databases

PRIDEi Q9CAH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G72590.1 ; AT1G72590.1 ; AT1G72590 .
GeneIDi 843591.
KEGGi ath:AT1G72590.

Organism-specific databases

TAIRi AT1G72590.

Phylogenomic databases

eggNOGi NOG330066.
HOGENOMi HOG000240963.
InParanoidi Q9CAH5.
OMAi THIRCED.
PhylomeDBi Q9CAH5.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_185286. Synthesis of Dolichyl-phosphate.

Gene expression databases

Genevestigatori Q9CAH5.

Family and domain databases

InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiPOED1_ARATH
AccessioniPrimary (citable) accession number: Q9CAH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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