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Q9CAG3 (LOX6_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipoxygenase 6, chloroplastic

Short name=AtLOX6
EC=1.13.11.12
Gene names
Name:LOX6
Ordered Locus Names:At1g67560
ORF Names:F12B7.11
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length917 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure By similarity. 13S-lipoxygenase that can use linolenic acid as substrates. Ref.7

Catalytic activity

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.

Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Lipid metabolism; oxylipin biosynthesis.

Subcellular location

Plastidchloroplast Potential Ref.6.

Sequence similarities

Belongs to the lipoxygenase family.

Contains 1 lipoxygenase domain.

Contains 1 PLAT domain.

Sequence caution

The sequence BAD95111.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4040Chloroplast Potential
Chain41 – 917877Lipoxygenase 6, chloroplastic
PRO_0000380595

Regions

Domain98 – 216119PLAT
Domain219 – 917699Lipoxygenase

Sites

Metal binding5751Iron; catalytic By similarity
Metal binding5801Iron; catalytic By similarity
Metal binding7671Iron; catalytic By similarity
Metal binding7711Iron; catalytic By similarity
Metal binding9171Iron; via carboxylate; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CAG3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 14405AD036EC3F64

FASTA917104,516
        10         20         30         40         50         60 
MFVASPVKTN FNGVSLVKSP AFSALSCRKQ HRVPISRQVR AVISREEKAV DQEDGKKSTN 

        70         80         90        100        110        120 
KPLINSSQFP WQRSKYTGSK TVTAVVKIRK KIKEKLTERF EHQLELFMKA IGQGMLIQLV 

       130        140        150        160        170        180 
SEEIDPETGK GRKSLESPVM GLPKAVKDPR YLVFTADFTV PINFGKPGAI LVTNLLSTEI 

       190        200        210        220        230        240 
CLSEIIIEDS TDTILFPANT WIHSKNDNPQ ARIIFRSQPC LPSETPDGIK ELREKDLVSV 

       250        260        270        280        290        300 
RGDGKGERKP HERIYDYDVY NDLGDPRKTE RVRPVLGVPE TPYPRRCRTG RPLVSKDPPC 

       310        320        330        340        350        360 
ESRGKEKEEF YVPRDEVFEE IKRDTFRAGR FKALFHNLVP SIAAALSNLD IPFTCFSDID 

       370        380        390        400        410        420 
NLYKSNIVLG HTEPKDTGLG GFIGGFMNGI LNVTETLLKY DTPAVIKWDR FAWLRDNEFG 

       430        440        450        460        470        480 
RQALAGVNPV NIELLKELPI RSNLDPALYG PQESVLTEEI IAREVEHYGT TIEKALEEKR 

       490        500        510        520        530        540 
LFLVDYHDIL LPFVEKINSI KEDPRKTYAS RTIFFYSKNG ALRPLAIELS LPPTAESENK 

       550        560        570        580        590        600 
FVYTHGHDAT THWIWKLAKA HVCSNDAGVH QLVNHWLRTH ASMEPYIIAT NRQLSTMHPV 

       610        620        630        640        650        660 
YKLLHPHMRY TLEINARARK SLINGGGIIE SCFTPGKYAM ELSSAAYKSM WRFDMEGLPA 

       670        680        690        700        710        720 
DLVRRGMAEE DSSAECGVRL VIDDYPYAAD GLLIWKAIKD LVESYVKHFY SDSKSITSDL 

       730        740        750        760        770        780 
ELQAWWDEIK NKGHYDKKDE PWWPKLNTTQ DLSQILTNMI WIASGQHAAI NFGQYPFGGY 

       790        800        810        820        830        840 
VPNRPTLLRK LIPQETDPDY EMFMRNPQYS FLGSLPTQLQ ATKVMAVQET LSTHSPDEEY 

       850        860        870        880        890        900 
LIELREVQRH WFQDEQVVKY FNKFSEELVK IEKTINERNK DKKLKNRTGA GMPPYELLLP 

       910 
TSPHGVTGRG IPNSISI 

« Hide

References

« Hide 'large scale' references
[1]"AtLOX6, the fourth chloroplastic 13-LOX from Arabidopsis thaliana."
Behrends V., Kunze S., Feussner I.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. expand/collapse author list , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-917.
Strain: cv. Columbia.
[6]"The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions."
Kleffmann T., Russenberger D., von Zychlinski A., Christopher W., Sjoelander K., Gruissem W., Baginsky S.
Curr. Biol. 14:354-362(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana."
Bannenberg G., Martinez M., Hamberg M., Castresana C.
Lipids 44:85-95(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ748537 mRNA. Translation: CAG38328.1.
AC011020 Genomic DNA. Translation: AAG52309.1.
CP002684 Genomic DNA. Translation: AEE34664.1.
AY081253 mRNA. Translation: AAL91142.1.
BT010546 mRNA. Translation: AAQ65169.1.
AK222124 mRNA. Translation: BAD95111.1. Different initiation.
AK230188 mRNA. Translation: BAF01997.1.
PIRB96699.
RefSeqNP_176923.1. NM_105423.2.
UniGeneAt.27885.

3D structure databases

ProteinModelPortalQ9CAG3.
SMRQ9CAG3. Positions 105-917.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9CAG3.
PRIDEQ9CAG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G67560.1; AT1G67560.1; AT1G67560.
GeneID843077.
KEGGath:AT1G67560.

Organism-specific databases

TAIRAT1G67560.

Phylogenomic databases

eggNOGNOG69653.
HOGENOMHOG000230469.
InParanoidQ9CAG3.
KOK00454.
OMATKVMAVQ.
PhylomeDBQ9CAG3.

Enzyme and pathway databases

UniPathwayUPA00382.

Gene expression databases

GenevestigatorQ9CAG3.

Family and domain databases

Gene3D2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERPTHR11771. PTHR11771. 1 hit.
PfamPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLOX6_ARATH
AccessionPrimary (citable) accession number: Q9CAG3
Secondary accession number(s): Q0WLL0, Q56WC0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names