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Q9CAG3

- LOX6_ARATH

UniProt

Q9CAG3 - LOX6_ARATH

Protein

Lipoxygenase 6, chloroplastic

Gene

LOX6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure By similarity. 13S-lipoxygenase that can use linolenic acid as substrates.1 PublicationPROSITE-ProRule annotation

    Catalytic activityi

    Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
    Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

    Cofactori

    Binds 1 iron ion per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi575 – 5751Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi580 – 5801Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi767 – 7671Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi771 – 7711Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi917 – 9171Iron; via carboxylate; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. linoleate 13S-lipoxygenase activity Source: UniProtKB

    GO - Biological processi

    1. jasmonic acid biosynthetic process Source: TAIR
    2. lipid oxidation Source: TAIR
    3. oxylipin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00382.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoxygenase 6, chloroplastic (EC:1.13.11.12)
    Short name:
    AtLOX6
    Gene namesi
    Name:LOX6
    Ordered Locus Names:At1g67560
    ORF Names:F12B7.11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G67560.

    Subcellular locationi

    Plastidchloroplast Curated

    GO - Cellular componenti

    1. chloroplast Source: TAIR
    2. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040ChloroplastSequence AnalysisAdd
    BLAST
    Chaini41 – 917877Lipoxygenase 6, chloroplasticPRO_0000380595Add
    BLAST

    Proteomic databases

    PaxDbiQ9CAG3.
    PRIDEiQ9CAG3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9CAG3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CAG3.
    SMRiQ9CAG3. Positions 105-917.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini98 – 216119PLATPROSITE-ProRule annotationAdd
    BLAST
    Domaini219 – 917699LipoxygenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lipoxygenase family.Curated
    Contains 1 lipoxygenase domain.PROSITE-ProRule annotation
    Contains 1 PLAT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG69653.
    HOGENOMiHOG000230469.
    InParanoidiQ9CAG3.
    KOiK00454.
    OMAiTKVMAVQ.
    PhylomeDBiQ9CAG3.

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    4.10.372.10. 1 hit.
    InterProiIPR008976. Lipase_LipOase.
    IPR000907. LipOase.
    IPR013819. LipOase_C.
    IPR020834. LipOase_CS.
    IPR020833. LipOase_Fe_BS.
    IPR001246. LipOase_pln.
    IPR027433. Lipoxygenase_domain_3.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11771. PTHR11771. 1 hit.
    PfamiPF00305. Lipoxygenase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PRINTSiPR00087. LIPOXYGENASE.
    PR00468. PLTLPOXGNASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48484. SSF48484. 1 hit.
    SSF49723. SSF49723. 1 hit.
    PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
    PS00081. LIPOXYGENASE_2. 1 hit.
    PS51393. LIPOXYGENASE_3. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CAG3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFVASPVKTN FNGVSLVKSP AFSALSCRKQ HRVPISRQVR AVISREEKAV    50
    DQEDGKKSTN KPLINSSQFP WQRSKYTGSK TVTAVVKIRK KIKEKLTERF 100
    EHQLELFMKA IGQGMLIQLV SEEIDPETGK GRKSLESPVM GLPKAVKDPR 150
    YLVFTADFTV PINFGKPGAI LVTNLLSTEI CLSEIIIEDS TDTILFPANT 200
    WIHSKNDNPQ ARIIFRSQPC LPSETPDGIK ELREKDLVSV RGDGKGERKP 250
    HERIYDYDVY NDLGDPRKTE RVRPVLGVPE TPYPRRCRTG RPLVSKDPPC 300
    ESRGKEKEEF YVPRDEVFEE IKRDTFRAGR FKALFHNLVP SIAAALSNLD 350
    IPFTCFSDID NLYKSNIVLG HTEPKDTGLG GFIGGFMNGI LNVTETLLKY 400
    DTPAVIKWDR FAWLRDNEFG RQALAGVNPV NIELLKELPI RSNLDPALYG 450
    PQESVLTEEI IAREVEHYGT TIEKALEEKR LFLVDYHDIL LPFVEKINSI 500
    KEDPRKTYAS RTIFFYSKNG ALRPLAIELS LPPTAESENK FVYTHGHDAT 550
    THWIWKLAKA HVCSNDAGVH QLVNHWLRTH ASMEPYIIAT NRQLSTMHPV 600
    YKLLHPHMRY TLEINARARK SLINGGGIIE SCFTPGKYAM ELSSAAYKSM 650
    WRFDMEGLPA DLVRRGMAEE DSSAECGVRL VIDDYPYAAD GLLIWKAIKD 700
    LVESYVKHFY SDSKSITSDL ELQAWWDEIK NKGHYDKKDE PWWPKLNTTQ 750
    DLSQILTNMI WIASGQHAAI NFGQYPFGGY VPNRPTLLRK LIPQETDPDY 800
    EMFMRNPQYS FLGSLPTQLQ ATKVMAVQET LSTHSPDEEY LIELREVQRH 850
    WFQDEQVVKY FNKFSEELVK IEKTINERNK DKKLKNRTGA GMPPYELLLP 900
    TSPHGVTGRG IPNSISI 917
    Length:917
    Mass (Da):104,516
    Last modified:June 1, 2001 - v1
    Checksum:i14405AD036EC3F64
    GO

    Sequence cautioni

    The sequence BAD95111.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ748537 mRNA. Translation: CAG38328.1.
    AC011020 Genomic DNA. Translation: AAG52309.1.
    CP002684 Genomic DNA. Translation: AEE34664.1.
    AY081253 mRNA. Translation: AAL91142.1.
    BT010546 mRNA. Translation: AAQ65169.1.
    AK222124 mRNA. Translation: BAD95111.1. Different initiation.
    AK230188 mRNA. Translation: BAF01997.1.
    PIRiB96699.
    RefSeqiNP_176923.1. NM_105423.2.
    UniGeneiAt.27885.

    Genome annotation databases

    EnsemblPlantsiAT1G67560.1; AT1G67560.1; AT1G67560.
    GeneIDi843077.
    KEGGiath:AT1G67560.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ748537 mRNA. Translation: CAG38328.1 .
    AC011020 Genomic DNA. Translation: AAG52309.1 .
    CP002684 Genomic DNA. Translation: AEE34664.1 .
    AY081253 mRNA. Translation: AAL91142.1 .
    BT010546 mRNA. Translation: AAQ65169.1 .
    AK222124 mRNA. Translation: BAD95111.1 . Different initiation.
    AK230188 mRNA. Translation: BAF01997.1 .
    PIRi B96699.
    RefSeqi NP_176923.1. NM_105423.2.
    UniGenei At.27885.

    3D structure databases

    ProteinModelPortali Q9CAG3.
    SMRi Q9CAG3. Positions 105-917.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9CAG3.
    PRIDEi Q9CAG3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G67560.1 ; AT1G67560.1 ; AT1G67560 .
    GeneIDi 843077.
    KEGGi ath:AT1G67560.

    Organism-specific databases

    TAIRi AT1G67560.

    Phylogenomic databases

    eggNOGi NOG69653.
    HOGENOMi HOG000230469.
    InParanoidi Q9CAG3.
    KOi K00454.
    OMAi TKVMAVQ.
    PhylomeDBi Q9CAG3.

    Enzyme and pathway databases

    UniPathwayi UPA00382 .

    Gene expression databases

    Genevestigatori Q9CAG3.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    4.10.372.10. 1 hit.
    InterProi IPR008976. Lipase_LipOase.
    IPR000907. LipOase.
    IPR013819. LipOase_C.
    IPR020834. LipOase_CS.
    IPR020833. LipOase_Fe_BS.
    IPR001246. LipOase_pln.
    IPR027433. Lipoxygenase_domain_3.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11771. PTHR11771. 1 hit.
    Pfami PF00305. Lipoxygenase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PRINTSi PR00087. LIPOXYGENASE.
    PR00468. PLTLPOXGNASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48484. SSF48484. 1 hit.
    SSF49723. SSF49723. 1 hit.
    PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
    PS00081. LIPOXYGENASE_2. 1 hit.
    PS51393. LIPOXYGENASE_3. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AtLOX6, the fourth chloroplastic 13-LOX from Arabidopsis thaliana."
      Behrends V., Kunze S., Feussner I.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-917.
      Strain: cv. Columbia.
    6. "The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions."
      Kleffmann T., Russenberger D., von Zychlinski A., Christopher W., Sjoelander K., Gruissem W., Baginsky S.
      Curr. Biol. 14:354-362(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana."
      Bannenberg G., Martinez M., Hamberg M., Castresana C.
      Lipids 44:85-95(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiLOX6_ARATH
    AccessioniPrimary (citable) accession number: Q9CAG3
    Secondary accession number(s): Q0WLL0, Q56WC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3