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Q9CAG3

- LOX6_ARATH

UniProt

Q9CAG3 - LOX6_ARATH

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Protein

Lipoxygenase 6, chloroplastic

Gene
LOX6, At1g67560, F12B7.11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure By similarity. 13S-lipoxygenase that can use linolenic acid as substrates.1 Publication

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Binds 1 iron ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi575 – 5751Iron; catalytic By similarity
Metal bindingi580 – 5801Iron; catalytic By similarity
Metal bindingi767 – 7671Iron; catalytic By similarity
Metal bindingi771 – 7711Iron; catalytic By similarity
Metal bindingi917 – 9171Iron; via carboxylate; catalytic By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB

GO - Biological processi

  1. jasmonic acid biosynthetic process Source: TAIR
  2. lipid oxidation Source: TAIR
  3. oxylipin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase 6, chloroplastic (EC:1.13.11.12)
Short name:
AtLOX6
Gene namesi
Name:LOX6
Ordered Locus Names:At1g67560
ORF Names:F12B7.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G67560.

Subcellular locationi

Plastidchloroplast Reviewed prediction 1 Publication

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040Chloroplast Reviewed predictionAdd
BLAST
Chaini41 – 917877Lipoxygenase 6, chloroplasticPRO_0000380595Add
BLAST

Proteomic databases

PaxDbiQ9CAG3.
PRIDEiQ9CAG3.

Expressioni

Gene expression databases

GenevestigatoriQ9CAG3.

Structurei

3D structure databases

ProteinModelPortaliQ9CAG3.
SMRiQ9CAG3. Positions 105-917.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 216119PLATAdd
BLAST
Domaini219 – 917699LipoxygenaseAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.
Contains 1 PLAT domain.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG69653.
HOGENOMiHOG000230469.
InParanoidiQ9CAG3.
KOiK00454.
OMAiTKVMAVQ.
PhylomeDBiQ9CAG3.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CAG3-1 [UniParc]FASTAAdd to Basket

« Hide

MFVASPVKTN FNGVSLVKSP AFSALSCRKQ HRVPISRQVR AVISREEKAV    50
DQEDGKKSTN KPLINSSQFP WQRSKYTGSK TVTAVVKIRK KIKEKLTERF 100
EHQLELFMKA IGQGMLIQLV SEEIDPETGK GRKSLESPVM GLPKAVKDPR 150
YLVFTADFTV PINFGKPGAI LVTNLLSTEI CLSEIIIEDS TDTILFPANT 200
WIHSKNDNPQ ARIIFRSQPC LPSETPDGIK ELREKDLVSV RGDGKGERKP 250
HERIYDYDVY NDLGDPRKTE RVRPVLGVPE TPYPRRCRTG RPLVSKDPPC 300
ESRGKEKEEF YVPRDEVFEE IKRDTFRAGR FKALFHNLVP SIAAALSNLD 350
IPFTCFSDID NLYKSNIVLG HTEPKDTGLG GFIGGFMNGI LNVTETLLKY 400
DTPAVIKWDR FAWLRDNEFG RQALAGVNPV NIELLKELPI RSNLDPALYG 450
PQESVLTEEI IAREVEHYGT TIEKALEEKR LFLVDYHDIL LPFVEKINSI 500
KEDPRKTYAS RTIFFYSKNG ALRPLAIELS LPPTAESENK FVYTHGHDAT 550
THWIWKLAKA HVCSNDAGVH QLVNHWLRTH ASMEPYIIAT NRQLSTMHPV 600
YKLLHPHMRY TLEINARARK SLINGGGIIE SCFTPGKYAM ELSSAAYKSM 650
WRFDMEGLPA DLVRRGMAEE DSSAECGVRL VIDDYPYAAD GLLIWKAIKD 700
LVESYVKHFY SDSKSITSDL ELQAWWDEIK NKGHYDKKDE PWWPKLNTTQ 750
DLSQILTNMI WIASGQHAAI NFGQYPFGGY VPNRPTLLRK LIPQETDPDY 800
EMFMRNPQYS FLGSLPTQLQ ATKVMAVQET LSTHSPDEEY LIELREVQRH 850
WFQDEQVVKY FNKFSEELVK IEKTINERNK DKKLKNRTGA GMPPYELLLP 900
TSPHGVTGRG IPNSISI 917
Length:917
Mass (Da):104,516
Last modified:June 1, 2001 - v1
Checksum:i14405AD036EC3F64
GO

Sequence cautioni

The sequence BAD95111.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ748537 mRNA. Translation: CAG38328.1.
AC011020 Genomic DNA. Translation: AAG52309.1.
CP002684 Genomic DNA. Translation: AEE34664.1.
AY081253 mRNA. Translation: AAL91142.1.
BT010546 mRNA. Translation: AAQ65169.1.
AK222124 mRNA. Translation: BAD95111.1. Different initiation.
AK230188 mRNA. Translation: BAF01997.1.
PIRiB96699.
RefSeqiNP_176923.1. NM_105423.2.
UniGeneiAt.27885.

Genome annotation databases

EnsemblPlantsiAT1G67560.1; AT1G67560.1; AT1G67560.
GeneIDi843077.
KEGGiath:AT1G67560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ748537 mRNA. Translation: CAG38328.1 .
AC011020 Genomic DNA. Translation: AAG52309.1 .
CP002684 Genomic DNA. Translation: AEE34664.1 .
AY081253 mRNA. Translation: AAL91142.1 .
BT010546 mRNA. Translation: AAQ65169.1 .
AK222124 mRNA. Translation: BAD95111.1 . Different initiation.
AK230188 mRNA. Translation: BAF01997.1 .
PIRi B96699.
RefSeqi NP_176923.1. NM_105423.2.
UniGenei At.27885.

3D structure databases

ProteinModelPortali Q9CAG3.
SMRi Q9CAG3. Positions 105-917.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9CAG3.
PRIDEi Q9CAG3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G67560.1 ; AT1G67560.1 ; AT1G67560 .
GeneIDi 843077.
KEGGi ath:AT1G67560.

Organism-specific databases

TAIRi AT1G67560.

Phylogenomic databases

eggNOGi NOG69653.
HOGENOMi HOG000230469.
InParanoidi Q9CAG3.
KOi K00454.
OMAi TKVMAVQ.
PhylomeDBi Q9CAG3.

Enzyme and pathway databases

UniPathwayi UPA00382 .

Gene expression databases

Genevestigatori Q9CAG3.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AtLOX6, the fourth chloroplastic 13-LOX from Arabidopsis thaliana."
    Behrends V., Kunze S., Feussner I.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 564-917.
    Strain: cv. Columbia.
  6. "The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions."
    Kleffmann T., Russenberger D., von Zychlinski A., Christopher W., Sjoelander K., Gruissem W., Baginsky S.
    Curr. Biol. 14:354-362(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana."
    Bannenberg G., Martinez M., Hamberg M., Castresana C.
    Lipids 44:85-95(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLOX6_ARATH
AccessioniPrimary (citable) accession number: Q9CAG3
Secondary accession number(s): Q0WLL0, Q56WC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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