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Protein

Probable ubiquitin-conjugating enzyme E2 12

Gene

UBC12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-ATH-5689896 Ovarian tumor domain proteases
R-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-9033241 Peroxisomal protein import
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 12 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 12
Gene namesi
Name:UBC12
Ordered Locus Names:At3g08700
ORF Names:F17O14.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G08700
TAIRilocus:2077788 AT3G08700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451811 – 149Probable ubiquitin-conjugating enzyme E2 12Add BLAST149

Proteomic databases

PaxDbiQ9C9Y7

Expressioni

Tissue specificityi

Ubiquitously expressed at very low levels.1 Publication

Gene expression databases

ExpressionAtlasiQ9C9Y7 baseline and differential
GenevisibleiQ9C9Y7 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G08700.1

Structurei

3D structure databases

ProteinModelPortaliQ9C9Y7
SMRiQ9C9Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233455
InParanoidiQ9C9Y7
OMAiRHPPANC
OrthoDBiEOG093617WZ
PhylomeDBiQ9C9Y7

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C9Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKRISREL RDMQRHPPAN CSAGPVAEED IFHWQATIMG PHDSPYSGGV
60 70 80 90 100
FTVSIDFSSD YPFKPPKVNF KTKVYHPNID SKGSICLDIL KEQWSPAPTT
110 120 130 140
SKVLLSICSL LTDPNPNDPL VPEIAHLYKV DKSKYESTAQ KWTQKYAMG
Length:149
Mass (Da):16,710
Last modified:June 1, 2001 - v1
Checksum:i090792870D52F9FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ027026 mRNA Translation: AAY44852.1
AC012562 Genomic DNA Translation: AAG51365.1
CP002686 Genomic DNA Translation: AEE74666.1
CP002686 Genomic DNA Translation: ANM65238.1
BT024821 mRNA Translation: ABD60704.1
RefSeqiNP_001319500.1, NM_001337764.1
NP_566332.1, NM_111704.2
UniGeneiAt.53221

Genome annotation databases

EnsemblPlantsiAT3G08700.1; AT3G08700.1; AT3G08700
AT3G08700.2; AT3G08700.2; AT3G08700
GeneIDi820017
GrameneiAT3G08700.1; AT3G08700.1; AT3G08700
AT3G08700.2; AT3G08700.2; AT3G08700
KEGGiath:AT3G08700

Similar proteinsi

Entry informationi

Entry nameiUBC12_ARATH
AccessioniPrimary (citable) accession number: Q9C9Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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