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Q9C9U2

- CDKD1_ARATH

UniProt

Q9C9U2 - CDKD1_ARATH

Protein

Cyclin-dependent kinase D-1

Gene

CDKD-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401ATPCurated
    Active sitei133 – 1331Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein binding Source: TAIR
    4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell differentiation Source: TAIR
    2. regulation of cell cycle Source: TAIR

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G73690-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase D-1 (EC:2.7.11.22, EC:2.7.11.23)
    Short name:
    CDKD;1
    Alternative name(s):
    CDK-activating kinase 3-At
    Short name:
    CAK3-At
    Gene namesi
    Name:CDKD-1
    Ordered Locus Names:At1g73690
    ORF Names:F25P22.11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G73690.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi40 – 401K → R: Prevents autophosphorylation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Cyclin-dependent kinase D-1PRO_0000293119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221PhosphotyrosineBy similarity
    Modified residuei166 – 1661PhosphothreonineBy similarity

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9C9U2.

    Expressioni

    Tissue specificityi

    Expressed at low levels in suspension cell culture, but not in plant organs.1 Publication

    Gene expression databases

    ArrayExpressiQ9C9U2.
    GenevestigatoriQ9C9U2.

    Interactioni

    Protein-protein interaction databases

    BioGridi28923. 18 interactions.
    IntActiQ9C9U2. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C9U2.
    SMRiQ9C9U2. Positions 7-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 291281Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    InParanoidiQ9C9U2.
    KOiK02202.
    OMAiHKENLHI.
    PhylomeDBiQ9C9U2.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9C9U2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPKKVADR YLKREVLGQG TYGVVFKATD TKNGETVAIK KIRLGKEKEG    50
    VNVTALREIK LLKELKHPHI IELIDAFPHK ENLHIVFEFM ETDLEAVIRD 100
    RNLYLSPGDV KSYLQMILKG LEYCHGKWVL HRDMKPNNLL IGPNGQLKLA 150
    DFGLARIFGS PGRKFTHQVF ARWYRAPELL FGAKQYDGAV DVWAAGCIFA 200
    ELLLRRPFLQ GNSDIDQLSK IFAAFGTPKA DQWPDMICLP DYVEYQFVPA 250
    PSLRSLLPTV SEDALDLLSK MFTYDPKSRI SIQQALKHRY FTSAPSPTDP 300
    LKLPRPVSKQ DAKSSDSKLE AIKVLSPAHK FRRVMPDRGK SGNGFKDQSV 350
    DVMRQASHDG QAPMSLDFTI LAERPPNRPT ITSADRSHLK RKLDLEFL 398
    Length:398
    Mass (Da):45,138
    Last modified:June 1, 2001 - v1
    Checksum:i32BA95E61E6D2C45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047275 mRNA. Translation: BAB62844.1.
    AC012679 Genomic DNA. Translation: AAG52081.1.
    CP002684 Genomic DNA. Translation: AEE35498.1.
    AY063843 mRNA. Translation: AAL36199.1.
    AY091227 mRNA. Translation: AAM14166.1.
    PIRiA96764.
    RefSeqiNP_177510.1. NM_106028.3.
    UniGeneiAt.17996.

    Genome annotation databases

    EnsemblPlantsiAT1G73690.1; AT1G73690.1; AT1G73690.
    GeneIDi843704.
    KEGGiath:AT1G73690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047275 mRNA. Translation: BAB62844.1 .
    AC012679 Genomic DNA. Translation: AAG52081.1 .
    CP002684 Genomic DNA. Translation: AEE35498.1 .
    AY063843 mRNA. Translation: AAL36199.1 .
    AY091227 mRNA. Translation: AAM14166.1 .
    PIRi A96764.
    RefSeqi NP_177510.1. NM_106028.3.
    UniGenei At.17996.

    3D structure databases

    ProteinModelPortali Q9C9U2.
    SMRi Q9C9U2. Positions 7-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 28923. 18 interactions.
    IntActi Q9C9U2. 2 interactions.

    Proteomic databases

    PRIDEi Q9C9U2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G73690.1 ; AT1G73690.1 ; AT1G73690 .
    GeneIDi 843704.
    KEGGi ath:AT1G73690.

    Organism-specific databases

    GeneFarmi 3285. 109.
    TAIRi AT1G73690.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    InParanoidi Q9C9U2.
    KOi K02202.
    OMAi HKENLHI.
    PhylomeDBi Q9C9U2.

    Enzyme and pathway databases

    BioCyci ARA:AT1G73690-MONOMER.

    Gene expression databases

    ArrayExpressi Q9C9U2.
    Genevestigatori Q9C9U2.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential phosphorylation activities of CDK-activating kinases in Arabidopsis thaliana."
      Shimotohno A., Matsubayashi S., Yamaguchi M., Uchimiya H., Umeda M.
      FEBS Lett. 534:69-74(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Genome-wide analysis of core cell cycle genes in Arabidopsis."
      Vandepoele K., Raes J., de Veylder L., Rouze P., Rombauts S., Inze D.
      Plant Cell 14:903-916(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    6. "The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis."
      Shimotohno A., Umeda-Hara C., Bisova K., Uchimiya H., Umeda M.
      Plant Cell 16:2954-2966(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-40.
    7. "Cell cycle regulation in plant development."
      Inze D., de Veylder L.
      Annu. Rev. Genet. 40:77-105(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiCDKD1_ARATH
    AccessioniPrimary (citable) accession number: Q9C9U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3