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Q9C9L4

- HMOX3_ARATH

UniProt

Q9C9L4 - HMOX3_ARATH

Protein

Heme oxygenase 3, chloroplastic

Gene

HO3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Plays a minor role in phytochrome assembly and photomorphogenesis.2 Publications

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    pH dependencei

    Optimum pH is 7.0.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: TAIR
    2. heme oxygenase (decyclizing) activity Source: TAIR
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme oxidation Source: InterPro
    2. photosynthesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Photosynthesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G69720-MONOMER.
    MetaCyc:AT1G69720-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase 3, chloroplastic (EC:1.14.99.3)
    Gene namesi
    Name:HO3
    Ordered Locus Names:At1g69720
    ORF Names:T6C23.8
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G69720.

    Subcellular locationi

    Plastidchloroplast 1 Publication

    GO - Cellular componenti

    1. chloroplast Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype under normal growth conditions.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5858ChloroplastSequence AnalysisAdd
    BLAST
    Chaini59 – 285227Heme oxygenase 3, chloroplasticPRO_0000412187Add
    BLAST

    Proteomic databases

    PRIDEiQ9C9L4.

    Expressioni

    Tissue specificityi

    Widely expressed at low levels.1 Publication

    Gene expression databases

    GenevestigatoriQ9C9L4.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G69720.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C9L4.
    SMRiQ9C9L4. Positions 153-280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG308332.
    HOGENOMiHOG000265822.
    InParanoidiQ9C9L4.
    KOiK00510.
    OMAiHIMANSG.
    PhylomeDBiQ9C9L4.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR016951. Haem_Oase_decyc_pln.
    [Graphical view]
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF030219. Heme_Oase_decyc_pln. 1 hit.
    SUPFAMiSSF48613. SSF48613. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C9L4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATTRLNPSC HFPASTRLSC ESYLGLRTTG RISYARTLTA PRGYLAVKAN    50
    GGQASVVTAA AITEKQQKKY PGESKGFVEE MRFVAMRLHT KDQAREGEKE 100
    SRSPEEGPVA KWEPTVEGYL HFLVDSKLVY DTLEGIIDGS NFPTYAGFKN 150
    TGLERAESLR KDLEWFKEQG YEIPEPMAPG KTYSEYLKDL AENDPQAFIC 200
    HFYNIYFAHS AGGQMIGTKV SKKILDNKEL EFYKWDGQLS QLLQNVRQKL 250
    NKVAEWWTRE EKSHCLEETE KSFKFSGEIL RLILS 285
    Length:285
    Mass (Da):32,434
    Last modified:June 1, 2001 - v1
    Checksum:iD552E638E7DFF241
    GO
    Isoform 2 (identifier: Q9C9L4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-227: VSKKILDN → LCRYLRRY
         228-285: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:227
    Mass (Da):25,607
    Checksum:iDC1F3852838F4265
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei220 – 2278VSKKILDN → LCRYLRRY in isoform 2. CuratedVSP_041653
    Alternative sequencei228 – 28558Missing in isoform 2. CuratedVSP_041654Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320022 Genomic DNA. Translation: AAK63006.1.
    AC013289 Genomic DNA. Translation: AAG52552.1.
    CP002684 Genomic DNA. Translation: AEE34966.1.
    CP002684 Genomic DNA. Translation: AEE34967.1.
    AY084250 mRNA. Translation: AAM60844.1.
    PIRiB96719.
    RefSeqiNP_001117574.1. NM_001124102.1. [Q9C9L4-2]
    NP_177130.1. NM_105640.3. [Q9C9L4-1]
    UniGeneiAt.35382.
    At.71252.

    Genome annotation databases

    EnsemblPlantsiAT1G69720.1; AT1G69720.1; AT1G69720. [Q9C9L4-1]
    GeneIDi843308.
    KEGGiath:AT1G69720.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320022 Genomic DNA. Translation: AAK63006.1 .
    AC013289 Genomic DNA. Translation: AAG52552.1 .
    CP002684 Genomic DNA. Translation: AEE34966.1 .
    CP002684 Genomic DNA. Translation: AEE34967.1 .
    AY084250 mRNA. Translation: AAM60844.1 .
    PIRi B96719.
    RefSeqi NP_001117574.1. NM_001124102.1. [Q9C9L4-2 ]
    NP_177130.1. NM_105640.3. [Q9C9L4-1 ]
    UniGenei At.35382.
    At.71252.

    3D structure databases

    ProteinModelPortali Q9C9L4.
    SMRi Q9C9L4. Positions 153-280.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G69720.1-P.

    Proteomic databases

    PRIDEi Q9C9L4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G69720.1 ; AT1G69720.1 ; AT1G69720 . [Q9C9L4-1 ]
    GeneIDi 843308.
    KEGGi ath:AT1G69720.

    Organism-specific databases

    TAIRi AT1G69720.

    Phylogenomic databases

    eggNOGi NOG308332.
    HOGENOMi HOG000265822.
    InParanoidi Q9C9L4.
    KOi K00510.
    OMAi HIMANSG.
    PhylomeDBi Q9C9L4.

    Enzyme and pathway databases

    BioCyci ARA:AT1G69720-MONOMER.
    MetaCyc:AT1G69720-MONOMER.

    Gene expression databases

    Genevestigatori Q9C9L4.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR016951. Haem_Oase_decyc_pln.
    [Graphical view ]
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF030219. Heme_Oase_decyc_pln. 1 hit.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The heme-oxygenase family required for phytochrome chromophore biosynthesis is necessary for proper photomorphogenesis in higher plants."
      Davis S.J., Bhoo S.H., Durski A.M., Walker J.M., Vierstra R.D.
      Plant Physiol. 126:656-669(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Multiple heme oxygenase family members contribute to the biosynthesis of the phytochrome chromophore in Arabidopsis."
      Emborg T.J., Walker J.M., Noh B., Vierstra R.D.
      Plant Physiol. 140:856-868(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    6. "Characterization of the haem oxygenase protein family in Arabidopsis thaliana reveals a diversity of functions."
      Gisk B., Yasui Y., Kohchi T., Frankenberg-Dinkel N.
      Biochem. J. 425:425-434(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES.

    Entry informationi

    Entry nameiHMOX3_ARATH
    AccessioniPrimary (citable) accession number: Q9C9L4
    Secondary accession number(s): B3H531
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3