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Protein

Probable histone H2A variant 3

Gene

At1g52740

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. May replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • defense response to bacterium Source: TAIR
  • response to temperature stimulus Source: TAIR

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-212300 PRC2 methylates histones and DNA
R-ATH-2299718 Condensation of Prophase Chromosomes
R-ATH-2559580 Oxidative Stress Induced Senescence
R-ATH-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-ATH-5578749 Transcriptional regulation by small RNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone H2A variant 3
Alternative name(s):
H2A.F/Z 3
HTA9
Gene namesi
Ordered Locus Names:At1g52740
ORF Names:F14G24.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G52740
TAIRilocus:2011456 AT1G52740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553141 – 134Probable histone H2A variant 3Add BLAST134

Proteomic databases

PaxDbiQ9C944
PRIDEiQ9C944

Expressioni

Gene expression databases

ExpressionAtlasiQ9C944 baseline and differential
GenevisibleiQ9C944 AT

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
CPK11Q390169EBI-1537419,EBI-979321

GO - Molecular functioni

Protein-protein interaction databases

BioGridi26932, 3 interactors
IntActiQ9C944, 3 interactors
STRINGi3702.AT1G52740.1

Structurei

3D structure databases

ProteinModelPortaliQ9C944
SMRiQ9C944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757 Eukaryota
COG5262 LUCA
HOGENOMiHOG000234652
InParanoidiQ9C944
KOiK11251
OMAiHRVQANG
OrthoDBiEOG09360UZS
PhylomeDBiQ9C944

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKGAKGLI MGKPSGSDKD KDKKKPITRS SRAGLQFPVG RVHRLLKTRS
60 70 80 90 100
TAHGRVGATA AVYTAAILEY LTAEVLELAG NASKDLKVKR ISPRHLQLAI
110 120 130
RGDEELDTLI KGTIAGGGVI PHIHKSLINK SAKE
Length:134
Mass (Da):14,272
Last modified:June 1, 2001 - v1
Checksum:iBE63E2B00DC3955A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019018 Genomic DNA Translation: AAG52265.1
CP002684 Genomic DNA Translation: AEE32847.1
AY054557 mRNA Translation: AAK96748.1
AY058147 mRNA Translation: AAL25563.1
AY084390 mRNA Translation: AAM60967.1
AY064631 mRNA Translation: AAL47344.1
PIRiD96568
RefSeqiNP_175683.1, NM_104152.4
UniGeneiAt.22624
At.37537

Genome annotation databases

EnsemblPlantsiAT1G52740.1; AT1G52740.1; AT1G52740
GeneIDi841707
GrameneiAT1G52740.1; AT1G52740.1; AT1G52740
KEGGiath:AT1G52740

Similar proteinsi

Entry informationi

Entry nameiH2AV3_ARATH
AccessioniPrimary (citable) accession number: Q9C944
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health