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Protein

Probable histone H2A variant 3

Gene

At1g52740

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. May replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • defense response to bacterium Source: TAIR
  • response to temperature stimulus Source: TAIR
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone H2A variant 3
Alternative name(s):
H2A.F/Z 3
HTA9
Gene namesi
Ordered Locus Names:At1g52740
ORF Names:F14G24.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G52740.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: GO_Central
  • nucleosome Source: UniProtKB-KW
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553141 – 134Probable histone H2A variant 3Add BLAST134

Proteomic databases

PaxDbiQ9C944.
PRIDEiQ9C944.

Expressioni

Gene expression databases

GenevisibleiQ9C944. AT.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
CPK11Q390169EBI-1537419,EBI-979321

Protein-protein interaction databases

BioGridi26932. 3 interactors.
IntActiQ9C944. 3 interactors.
STRINGi3702.AT1G52740.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C944.
SMRiQ9C944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
HOGENOMiHOG000234652.
InParanoidiQ9C944.
KOiK11251.
OMAiCFCDASI.
OrthoDBiEOG09360UZS.
PhylomeDBiQ9C944.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9C944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKGAKGLI MGKPSGSDKD KDKKKPITRS SRAGLQFPVG RVHRLLKTRS
60 70 80 90 100
TAHGRVGATA AVYTAAILEY LTAEVLELAG NASKDLKVKR ISPRHLQLAI
110 120 130
RGDEELDTLI KGTIAGGGVI PHIHKSLINK SAKE
Length:134
Mass (Da):14,272
Last modified:June 1, 2001 - v1
Checksum:iBE63E2B00DC3955A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019018 Genomic DNA. Translation: AAG52265.1.
CP002684 Genomic DNA. Translation: AEE32847.1.
AY054557 mRNA. Translation: AAK96748.1.
AY058147 mRNA. Translation: AAL25563.1.
AY084390 mRNA. Translation: AAM60967.1.
AY064631 mRNA. Translation: AAL47344.1.
PIRiD96568.
RefSeqiNP_175683.1. NM_104152.4.
UniGeneiAt.22624.
At.37537.

Genome annotation databases

EnsemblPlantsiAT1G52740.1; AT1G52740.1; AT1G52740.
GeneIDi841707.
GrameneiAT1G52740.1; AT1G52740.1; AT1G52740.
KEGGiath:AT1G52740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019018 Genomic DNA. Translation: AAG52265.1.
CP002684 Genomic DNA. Translation: AEE32847.1.
AY054557 mRNA. Translation: AAK96748.1.
AY058147 mRNA. Translation: AAL25563.1.
AY084390 mRNA. Translation: AAM60967.1.
AY064631 mRNA. Translation: AAL47344.1.
PIRiD96568.
RefSeqiNP_175683.1. NM_104152.4.
UniGeneiAt.22624.
At.37537.

3D structure databases

ProteinModelPortaliQ9C944.
SMRiQ9C944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi26932. 3 interactors.
IntActiQ9C944. 3 interactors.
STRINGi3702.AT1G52740.1.

Proteomic databases

PaxDbiQ9C944.
PRIDEiQ9C944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G52740.1; AT1G52740.1; AT1G52740.
GeneIDi841707.
GrameneiAT1G52740.1; AT1G52740.1; AT1G52740.
KEGGiath:AT1G52740.

Organism-specific databases

TAIRiAT1G52740.

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
HOGENOMiHOG000234652.
InParanoidiQ9C944.
KOiK11251.
OMAiCFCDASI.
OrthoDBiEOG09360UZS.
PhylomeDBiQ9C944.

Miscellaneous databases

PROiQ9C944.

Gene expression databases

GenevisibleiQ9C944. AT.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR032458. Histone_H2A_CS.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
[Graphical view]
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00046. HISTONE_H2A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2AV3_ARATH
AccessioniPrimary (citable) accession number: Q9C944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.