Q9C8W3 (FUT13_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-(1,4)-fucosyltransferase
EC=2.4.1.-

Alternative name(s):
FT4-M
FucTC
Fucosyltransferase 13
Short name=AtFUT13
Galactoside 3(4)-L-fucosyltransferase

Gene names

Name:	FUT13
Ordered Locus Names:	At1g71990
ORF Names:	F17M19.14

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in cell wall synthesis. Catalyzes alpha-1,4 glycosidic linkages and generates Lewis-a epitopes.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Tissue specificity	Present in root, stem, flower buds and green siliques.
Sequence similarities	Belongs to the glycosyltransferase 10 family.
Caution	It is uncertain whether Met-1 or Met-9 is the initiator.
Sequence caution	The sequence AAG52222.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Lewis a epitope biosynthetic process Inferred from direct assay. Source: TAIR cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW protein glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fucosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Alpha-(1,4)-fucosyltransferase		PRO_0000221126
Regions
	Topological domain	1 – 4	4	Cytoplasmic Potential
	Transmembrane	5 – 27	23	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	28 – 401	374	Lumenal Potential
Amino acid modifications
	Glycosylation	85	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9C8W3 [UniParc]. Last modified September 26, 2001. Version 2. Checksum: E2DB2B48550C36D6	FASTA	401	45,098
	10 20 30 40 50 60 MPMRYLNAMA ALLMMFFTLL ILSFTGILEF PSASTSMEHS IDPEPKLSDS TSDPFSDVLV 70 80 90 100 110 120 AYKKWDFEVG CARFRENHKD AILGNVSSGS LQEFGCGKLK MKHVKVLVKG WTWIPDNLEN 130 140 150 160 170 180 LYSCRCGMTC LWTKSSVLAD SPDALLFETT TPPLQRRVGD PLRVYMELEA GRKRSGREDI 190 200 210 220 230 240 FISYHAKDDV QTTYAGSLFH NNRNYHISPH KNNDVLVYWS SSRCLPHRDR LAKSLLDLIP 250 260 270 280 290 300 HHSFGKCLNN VGGLDSALSM YPECVAEHNA EAKWYDHLHC AMSHYKFVLA IENTAVESYV 310 320 330 340 350 360 TEKLFYALDS GSVPIYFGAS NVQDFVPPHS VIDGSKFGSM QELAAYVKRL GDDPVAYSEY 370 380 390 400 HAWRRCGLMG NYGKTRAVSL DTLPCRLCEE ISRRGGKNAG V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of cDNAs encoding alpha1,3-fucosyltransferase homologues from Arabidopsis thaliana." Wilson I.B., Rendic D., Freilinger A., Dumic J., Altmann F., Mucha J., Muller S., Hauser M.T. Biochim. Biophys. Acta 1527:88-96(2001) [PubMed: 11420147] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. Tissue: Root.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"The presence of Lewis a epitopes in Arabidopsis thaliana glycoconjugates depends on an active alpha4-fucosyltransferase gene." Leonard R., Costa G., Darrambide E., Lhernould S., Fleurat-Lessard P., Carlue M., Gomord V., Faye L., Maftah A. Glycobiology 12:299-306(2002) [PubMed: 12070072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-401.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ404862 mRNA. Translation: CAC38049.1. AC021665 Genomic DNA. Translation: AAG52222.1. Different initiation. CP002684 Genomic DNA. Translation: AEE35261.1. AY026941 mRNA. Translation: AAK11728.1.
IPI	IPI00542520.
PIR	H96742.
RefSeq	NP_177344.2. NM_105857.3.
UniGene	At.22334.
3D structure databases
ProteinModelPortal	Q9C8W3.
ModBase	Search...
Protein family/group databases
CAZy	GT10. Glycosyltransferase Family 10.
Proteomic databases
PRIDE	Q9C8W3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G71990.1; AT1G71990.1; AT1G71990.
GeneID	843530.
GenomeReviews	Gene locus AT1G71990 in contig CT485782_GR.
KEGG	ath:AT1G71990.
NMPDR	fig|3702.1.peg.6684.
Organism-specific databases
TAIR	At1g71990.
Phylogenomic databases
GeneTree	EPGT00070000030487.
HOGENOM	HBG589640.
InParanoid	Q9C8W3.
OMA	LLFETTT.
PhylomeDB	Q9C8W3.
ProtClustDB	CLSN2680641.
Gene expression databases
ArrayExpress	Q9C8W3.
Genevestigator	Q9C8W3.
GermOnline	AT1G71990. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR017177. Alpha-1_3/4-FUT_pln. IPR001503. Glyco_trans_10. [Graphical view]
KO	K14412.
PANTHER	PTHR11929. Glyco_trans_10. 1 hit.
Pfam	PF00852. Glyco_transf_10. 1 hit. [Graphical view]
PIRSF	PIRSF037334. Alpha1_3/4FUT_pln. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUT13_ARATH

Accession

Primary (citable) accession number: Q9C8W3
Secondary accession number(s): Q8RYC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	September 26, 2001
Last modified:	November 16, 2011
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program