Reviewed, UniProtKB/Swiss-Prot Q9C8H1 (AB11C_ARATH)

Names and origin

Protein names

Recommended name:
    ABC transporter C family member 11
      Short name=ABC transporter ABCC.11
      Short name=AtABCC11
    EC=3.6.3.44
Alternative name(s):
    Multidrug resistance-associated protein 12
    Glutathione S-conjugate-transporting ATPase 12
    ATP-energized glutathione S-conjugate pump 12

Gene names

Name:	ABCC11
Synonyms:	MRP11, MRP12
Ordered Locus Names:	At1g30420
ORF Names:	F26G16.1, T4K22.1

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	1495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Pump for glutathione S-conjugates By similarity.
Catalytic activity	ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Ubiquitous. Ref.4
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Sequence caution	The sequence AAF19743.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAG51094.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1495	1495	ABC transporter C family member 11		PRO_0000226083
Regions
	Transmembrane	32 – 52	21	Potential
	Transmembrane	76 – 96	21	Potential
	Transmembrane	110 – 130	21	Potential
	Transmembrane	146 – 166	21	Potential
	Transmembrane	182 – 202	21	Potential
	Transmembrane	337 – 357	21	Potential
	Transmembrane	420 – 440	21	Potential
	Transmembrane	441 – 461	21	Potential
	Transmembrane	528 – 548	21	Potential
	Transmembrane	907 – 927	21	Potential
	Transmembrane	949 – 969	21	Potential
	Transmembrane	1042 – 1062	21	Potential
	Transmembrane	1142 – 1162	21	Potential
	Transmembrane	1166 – 1186	21	Potential
	Domain	303 – 583	281	ABC transmembrane type-1 1
	Domain	615 – 839	225	ABC transporter 1
	Domain	914 – 1198	285	ABC transmembrane type-1 2
	Domain	1235 – 1469	235	ABC transporter 2
	Nucleotide binding	650 – 657	8	ATP 1 Potential
	Nucleotide binding	1269 – 1276	8	ATP 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9C8H1-1 [UniParc]. Last modified March 7, 2006. Version 2. Checksum: 9318F5DC045C35F2	FASTA	1,495	168,104
	10 20 30 40 50 60 MGFEALNWYC KPIAEGFWEK TPDGAFGAYT PCAIDSLVMI VSNSVLLGLC FYRIWITLYN 70 80 90 100 110 120 AKAQIYVLRK MYYHCVLWIL ACCCVVEPVL RLVMGISLFD MGDETDLPPF EVASLMVEAF 130 140 150 160 170 180 AWFAMLVLIG LETKQYVKEF RWYVRFGVVY VLVADAVLLD LVLPLKNSIN RTALYLCISS 190 200 210 220 230 240 RCCQALFGIL LLVYIPELDL YPDYHILNNE SLDNVEYDAL PGGVNICPER YASIFSGIYF 250 260 270 280 290 300 SWMTPLMQLG YRKPITERDV WQLDQWDQTE TLIKRFQRCW TEESRRPKPW LLRALNNSLG 310 320 330 340 350 360 RRFWLGGIFK VGHDLSQFVG PVILSHILQS MIEGDPAWVG YVYAFLIFFG VTFGVLCQSQ 370 380 390 400 410 420 YFQHVGRVGF RLRSTLVAAI FHKSLRLTNK ARKNFASGKV TNMITTDANA LQLIAEQLHG 430 440 450 460 470 480 LWSAPFRIIV SMVLLYQQLG VASIFGSLIL FLLIPFQTLI VRKMRKLTKE GLQWTDKRVG 490 500 510 520 530 540 IIYEILASMD IVKCYAWEKS FESRIQGIRN EELSWFRKAQ LLSAFNSFIL NSTPVVVTLV 550 560 570 580 590 600 SFGVYVLLGG DLTPARAFTS LSLFAVLRSP LSTLPNLISQ AVNANVSLQR IEELLLSEER 610 620 630 640 650 660 ILAQNPPLQP GAPAISIKNG YFSWDSKTSK PTLSDINLEI PVGSLVAIVG GTGEGKTSLI 670 680 690 700 710 720 SAMLGELSHA ETSSVDIRGS VAYVPQVSWI FNATLRENIL FGSDFESERY WRAIDVTALQ 730 740 750 760 770 780 HDLDLFPGRD RTEIGERGVN ISGGQKQRVS MARAVYSNSD IYIFDDPFSA LDAHVAHQVF 790 800 810 820 830 840 DSCVKHELKG KTRVLVTNQL HFLPLMDRII LVSEGMIKEE GNFAELSKSG TLFKKLMENA 850 860 870 880 890 900 GKMDATQEVN TNDENISKLG PTVTIDVSER SLGSIQQGKW GRSMLVKQEE RETGIISWDV 910 920 930 940 950 960 VMRYNKAVGG LWVVMILLVC YLTTEVLRVL SSTWLSIWTD QSTPKSYSPG FYIVVYALLG 970 980 990 1000 1010 1020 FGQVAVTFTN SFWLISSSLH AAKRLHDAML NSILRAPMLF FETNPTGRVI NRFSKDIGDI 1030 1040 1050 1060 1070 1080 DRNVANLMNM FMNQLWQLLS TFALIGIVST ISLWAIMPLL ILFYATYIYY QSTSREVRRL 1090 1100 1110 1120 1130 1140 DSVTRSPIYA LFGEALNGLS SIRAYKAYDR MAKINGKSMD NNIRFTLAST SSNRWLTIRS 1150 1160 1170 1180 1190 1200 ESLGGVMIWL TATFAVLRYG NAENQAVFAS TMGLLLSYTL NITTLLSGVL RQASKAENSL 1210 1220 1230 1240 1250 1260 NSVERVGNYI DLPSEATAII ENNRPVSGWP SRGSIQFEDV HLRYRPGLPP VLHGLSFFVY 1270 1280 1290 1300 1310 1320 PSEKVGVVGR TGAGKSSMLN ALYRIVELEK GRILIDDYDV AKFGLTDLRR VLSIIPQSPV 1330 1340 1350 1360 1370 1380 LFSGTVRFNI DPFSEHNDAD LWEALERAHI KDVIDRNPFG LDAEVSEGGE NFSVGQRQLL 1390 1400 1410 1420 1430 1440 SLARALLRRS KILFLDEATA SVDVRTDSLI QRTIREEFKS CTMLIIAHRL NTIIDCDKIL 1450 1460 1470 1480 1490 VLSSGQVLEY DSPQELLSRD TSAFFKMVHS TGPENGQYLS NLVFERRGNG MSQGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"The Arabidopsis thaliana ABC protein superfamily, a complete inventory." Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A. J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[3]	"Multifunctionality of plant ABC transporters -- more than just detoxifiers." Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B. Planta 214:345-355(2002) [PubMed: 11855639] [Abstract] Cited for: GENE FAMILY.
[4]	"Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana." Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D., Martinoia E., Schulz B. Planta 216:107-119(2002) [PubMed: 12430019] [Abstract] Cited for: TISSUE SPECIFICITY.
[5]	"Plant ABC proteins - a unified nomenclature and updated inventory." Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L. Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC009917 Genomic DNA. Translation: AAF19743.1. Sequence problems. AC025295 Genomic DNA. Translation: AAG51094.1. Sequence problems.
IPI	IPI00535365.
PIR	F86428.
RefSeq	NP_174331.2.
UniGene	At.51838
3D structure databases
HSSP	HSSP built from PDB template 1R0Z based on UniProtKB P26361.
ModBase	Search...
Genome annotation databases
GeneID	839922.
GenomeReviews	Gene locus AT1G30420 in contig CT485782_GR.
KEGG	ath:AT1G30420.
Organism-specific databases
TAIR	At1g30420.
Enzyme and pathway databases
BRENDA	3.6.3.44. 302.
Gene expression databases
Genevestigator	Q9C8H1.
GermOnline	AT1G30420. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AB11C_ARATH

Accession

Primary (citable) accession number: Q9C8H1
Secondary accession number(s): Q9S9R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	October 13, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)