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Protein

ABC transporter C family member 11

Gene

ABCC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Pump for glutathione S-conjugates.By similarity

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi650 – 657ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1269 – 1276ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G30420-MONOMER.
ReactomeiR-ATH-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.
R-ATH-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-ATH-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter C family member 11 (EC:3.6.3.44)
Short name:
ABC transporter ABCC.11
Short name:
AtABCC11
Alternative name(s):
ATP-energized glutathione S-conjugate pump 12
Glutathione S-conjugate-transporting ATPase 12
Multidrug resistance-associated protein 12
Gene namesi
Name:ABCC11
Synonyms:MRP11, MRP12
Ordered Locus Names:At1g30420
ORF Names:F26G16.1, T4K22.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G30420.
TAIRilocus:2028155. AT1G30420.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei76 – 96HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei110 – 130HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei146 – 166HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei182 – 202HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei337 – 357HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei420 – 440HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei441 – 461HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei528 – 548HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei907 – 927HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei949 – 969HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1042 – 1062HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1142 – 1162HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1166 – 1186HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260831 – 1495ABC transporter C family member 11Add BLAST1495

Proteomic databases

PaxDbiQ9C8H1.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

GenevisibleiQ9C8H1. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G30420.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C8H1.
SMRiQ9C8H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini303 – 583ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini615 – 839ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini914 – 1198ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST285
Domaini1235 – 1469ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ9C8H1.
OMAiYVRGLYM.
OrthoDBiEOG093611PX.
PhylomeDBiQ9C8H1.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9C8H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFEALNWYC KPIAEGFWEK TPDGAFGAYT PCAIDSLVMI VSNSVLLGLC
60 70 80 90 100
FYRIWITLYN AKAQIYVLRK MYYHCVLWIL ACCCVVEPVL RLVMGISLFD
110 120 130 140 150
MGDETDLPPF EVASLMVEAF AWFAMLVLIG LETKQYVKEF RWYVRFGVVY
160 170 180 190 200
VLVADAVLLD LVLPLKNSIN RTALYLCISS RCCQALFGIL LLVYIPELDL
210 220 230 240 250
YPDYHILNNE SLDNVEYDAL PGGVNICPER YASIFSGIYF SWMTPLMQLG
260 270 280 290 300
YRKPITERDV WQLDQWDQTE TLIKRFQRCW TEESRRPKPW LLRALNNSLG
310 320 330 340 350
RRFWLGGIFK VGHDLSQFVG PVILSHILQS MIEGDPAWVG YVYAFLIFFG
360 370 380 390 400
VTFGVLCQSQ YFQHVGRVGF RLRSTLVAAI FHKSLRLTNK ARKNFASGKV
410 420 430 440 450
TNMITTDANA LQLIAEQLHG LWSAPFRIIV SMVLLYQQLG VASIFGSLIL
460 470 480 490 500
FLLIPFQTLI VRKMRKLTKE GLQWTDKRVG IIYEILASMD IVKCYAWEKS
510 520 530 540 550
FESRIQGIRN EELSWFRKAQ LLSAFNSFIL NSTPVVVTLV SFGVYVLLGG
560 570 580 590 600
DLTPARAFTS LSLFAVLRSP LSTLPNLISQ AVNANVSLQR IEELLLSEER
610 620 630 640 650
ILAQNPPLQP GAPAISIKNG YFSWDSKTSK PTLSDINLEI PVGSLVAIVG
660 670 680 690 700
GTGEGKTSLI SAMLGELSHA ETSSVDIRGS VAYVPQVSWI FNATLRENIL
710 720 730 740 750
FGSDFESERY WRAIDVTALQ HDLDLFPGRD RTEIGERGVN ISGGQKQRVS
760 770 780 790 800
MARAVYSNSD IYIFDDPFSA LDAHVAHQVF DSCVKHELKG KTRVLVTNQL
810 820 830 840 850
HFLPLMDRII LVSEGMIKEE GNFAELSKSG TLFKKLMENA GKMDATQEVN
860 870 880 890 900
TNDENISKLG PTVTIDVSER SLGSIQQGKW GRSMLVKQEE RETGIISWDV
910 920 930 940 950
VMRYNKAVGG LWVVMILLVC YLTTEVLRVL SSTWLSIWTD QSTPKSYSPG
960 970 980 990 1000
FYIVVYALLG FGQVAVTFTN SFWLISSSLH AAKRLHDAML NSILRAPMLF
1010 1020 1030 1040 1050
FETNPTGRVI NRFSKDIGDI DRNVANLMNM FMNQLWQLLS TFALIGIVST
1060 1070 1080 1090 1100
ISLWAIMPLL ILFYATYIYY QSTSREVRRL DSVTRSPIYA LFGEALNGLS
1110 1120 1130 1140 1150
SIRAYKAYDR MAKINGKSMD NNIRFTLAST SSNRWLTIRS ESLGGVMIWL
1160 1170 1180 1190 1200
TATFAVLRYG NAENQAVFAS TMGLLLSYTL NITTLLSGVL RQASKAENSL
1210 1220 1230 1240 1250
NSVERVGNYI DLPSEATAII ENNRPVSGWP SRGSIQFEDV HLRYRPGLPP
1260 1270 1280 1290 1300
VLHGLSFFVY PSEKVGVVGR TGAGKSSMLN ALYRIVELEK GRILIDDYDV
1310 1320 1330 1340 1350
AKFGLTDLRR VLSIIPQSPV LFSGTVRFNI DPFSEHNDAD LWEALERAHI
1360 1370 1380 1390 1400
KDVIDRNPFG LDAEVSEGGE NFSVGQRQLL SLARALLRRS KILFLDEATA
1410 1420 1430 1440 1450
SVDVRTDSLI QRTIREEFKS CTMLIIAHRL NTIIDCDKIL VLSSGQVLEY
1460 1470 1480 1490
DSPQELLSRD TSAFFKMVHS TGPENGQYLS NLVFERRGNG MSQGG
Length:1,495
Mass (Da):168,104
Last modified:March 7, 2006 - v2
Checksum:i9318F5DC045C35F2
GO

Sequence cautioni

The sequence AAF19743 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG51094 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009917 Genomic DNA. Translation: AAF19743.1. Sequence problems.
AC025295 Genomic DNA. Translation: AAG51094.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE31215.1.
PIRiF86428.
RefSeqiNP_001319112.1. NM_001332898.1.
UniGeneiAt.51838.

Genome annotation databases

EnsemblPlantsiAT1G30420.1; AT1G30420.1; AT1G30420.
GeneIDi839922.
GrameneiAT1G30420.1; AT1G30420.1; AT1G30420.
KEGGiath:AT1G30420.

Similar proteinsi

Entry informationi

Entry nameiAB11C_ARATH
AccessioniPrimary (citable) accession number: Q9C8H1
Secondary accession number(s): Q9S9R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: June 7, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families