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Protein

ABC transporter C family member 12

Gene

ABCC12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Pump for glutathione S-conjugates.By similarity

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi650 – 657ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1269 – 1276ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G30410-MONOMER.
ReactomeiR-ATH-114608. Platelet degranulation.
R-ATH-2142850. Hyaluronan biosynthesis and export.
R-ATH-382556. ABC-family proteins mediated transport.
R-ATH-5689880. Ub-specific processing proteases.
R-ATH-8856825. Cargo recognition for clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter C family member 12 (EC:3.6.3.44)
Short name:
ABC transporter ABCC.12
Short name:
AtABCC12
Alternative name(s):
ATP-energized glutathione S-conjugate pump 13
Glutathione S-conjugate-transporting ATPase 13
Multidrug resistance-associated protein 13
Gene namesi
Name:ABCC12
Synonyms:MRP12, MRP13
Ordered Locus Names:At1g30410
ORF Names:T4K22.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G30410.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei76 – 96HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei110 – 130HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei146 – 166HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei173 – 195HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei303 – 323HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei337 – 357HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei420 – 440HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei441 – 461HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei528 – 548HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei558 – 578HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei907 – 927HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei949 – 969HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1042 – 1062HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1140 – 1160HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1166 – 1186HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260841 – 1495ABC transporter C family member 12Add BLAST1495

Proteomic databases

PaxDbiQ9C8H0.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ExpressionAtlasiQ9C8H0. baseline and differential.
GenevisibleiQ9C8H0. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G30410.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C8H0.
SMRiQ9C8H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini303 – 583ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini615 – 839ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini914 – 1198ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST285
Domaini1235 – 1469ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ9C8H0.
OrthoDBiEOG093600AW.
PhylomeDBiQ9C8H0.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9C8H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFEALNWYC KPVADGFWEK AVDGAFGAYT PCAIDSLVML VSHFVLLGLC
60 70 80 90 100
FYRIWIIFHN TKAQIYVLRK KYYNCVLGLL ACYCVVEPVL RLVMGISLFD
110 120 130 140 150
MDEETDFPPF EVASLMVEAF AWFSMLVLIG LETKQYVKEF RWYVRFGVLY
160 170 180 190 200
VLVADAVLLD LVLPLKNSIN RTALYLFISS RCSQALFGIL LLIYIPELDP
210 220 230 240 250
YPGYHIVNNE PLDNVEYDAL RGGEHICPER HASIFSRIYF GWITPLMQLG
260 270 280 290 300
YRKPITEKDV WQLDKWDQTE TLIKRFQRCW TEESRRPKPW LLRALNNSLG
310 320 330 340 350
GRFWLAGIFK IGNDLSQFVG PVILSHLLRS MQEGDPAWVG YVYAFIIFVG
360 370 380 390 400
VTLGVLCEAQ YFQNVWRVGF RLRSTLVAAI FHKSLRLTHE ARKNFASGKV
410 420 430 440 450
TNMITTDANA LQQISQQLHG LWSAPFRIIV SMILLYQQLG VASLFGSLIL
460 470 480 490 500
FLLIPLQTLI ISKMRKLTKE GLQWTDKRVG ITNEILSSMD TVKCYAWEKS
510 520 530 540 550
FESRIQGIRN EELSWFRKAQ LLSAFNSFIL NSIPVVVTVV SFGVFVLLGG
560 570 580 590 600
DLTPARAFTS LSLFAVLRFP LNMLPNLLSQ VVNANVSLQR IEELLLSEER
610 620 630 640 650
ILAQNPPLQP GTPAISIKNG YFSWDSKTTK PTLSDINLEI PVGTLVAIVG
660 670 680 690 700
GTGEGKTSLI SAMLGELSHA ETTSVVIRGS VAYVPQVSWI FNATVRENIL
710 720 730 740 750
FGSDFESERY WRAIDATALQ HDLDLLPGRD LTEIGERGVN ISGGQKQRVS
760 770 780 790 800
MARAVYSNSD VYIFDDPLSA LDAHVAHQVF DSCMKDELRG KTRVLVTNQL
810 820 830 840 850
HFLPLMDKII LVSEGMIKEE GTFVELSKSG ILFKKLMENA GKMDATQEVN
860 870 880 890 900
TNDENILKLG PTVTVDVSER NLGSTKQGKR RRSVLIKQEE RETGIISWNV
910 920 930 940 950
LMRYKEAVGG LWVVMILLAC YLATEVLRVS SSTWLSIWTD QSTSKNYSPG
960 970 980 990 1000
FYIVVYALLG FGQVAVTFTN SFWLITSSLH AARRLHDAML SSILRAPMLF
1010 1020 1030 1040 1050
FHTNPTGRVI NRFSKDIGDI DRNVANLMNM FMNQLWQLLS TFALIGTVST
1060 1070 1080 1090 1100
ISLWAIMPLL ILFYAAYLYY QSTSREVRRL DSVTRSPIYA QFGEALNGLS
1110 1120 1130 1140 1150
SIRAYKAYDR MAKINGKSMD NNIRFTLANT SSNRWLTIRL ETLGGVMIWL
1160 1170 1180 1190 1200
TATFAVLQNG NTNNQAGFAS TMGLLLSYTL NITSLLSGVL RQASRAENSL
1210 1220 1230 1240 1250
NSVERVGNYI DLPSEATDII ENNRPVCGWP SGGSIKFEDV HLRYRPGLPP
1260 1270 1280 1290 1300
VLHGLTFFVS PSEKVGVVGR TGAGKSSMLN ALFRIVEVEK GRIMIDDCDV
1310 1320 1330 1340 1350
AKFGLTDVRR VLSIIPQSPV LFSGTVRFNI DPFSEHNDAG LWEALHRAHI
1360 1370 1380 1390 1400
KDVISRNPFG LDAEVCEGGE NFSVGQRQLL SLARALLRRS KILVLDEATA
1410 1420 1430 1440 1450
SVDVRTDSLI QRTIREEFKS CTMLVIAHRL NTIIDCDKIL VLSSGQVLEY
1460 1470 1480 1490
DSPQELLSRD TSAFFRMVHS TGPANAQYLS NLVFERRENG MSVGG
Length:1,495
Mass (Da):167,956
Last modified:June 1, 2001 - v1
Checksum:iD29EF05C6D6BDE13
GO

Sequence cautioni

The sequence AEE31214 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025295 Genomic DNA. Translation: AAG51100.1.
CP002684 Genomic DNA. Translation: AEE31214.1. Sequence problems.
CP002684 Genomic DNA. Translation: ANM60872.1.
CP002684 Genomic DNA. Translation: ANM60873.1.
CP002684 Genomic DNA. Translation: ANM60875.1.
PIRiE86428.
RefSeqiNP_001319111.1. NM_001332892.1.
NP_001323123.1. NM_001332893.1.
NP_001323124.1. NM_001332895.1.
NP_001323126.1. NM_001332897.1.
UniGeneiAt.40558.

Genome annotation databases

EnsemblPlantsiAT1G30410.2; AT1G30410.2; AT1G30410.
AT1G30410.4; AT1G30410.4; AT1G30410.
AT1G30410.6; AT1G30410.6; AT1G30410.
GeneIDi839921.
GrameneiAT1G30410.2; AT1G30410.2; AT1G30410.
AT1G30410.4; AT1G30410.4; AT1G30410.
AT1G30410.6; AT1G30410.6; AT1G30410.
KEGGiath:AT1G30410.

Similar proteinsi

Entry informationi

Entry nameiAB12C_ARATH
AccessioniPrimary (citable) accession number: Q9C8H0
Secondary accession number(s): F4I4U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families