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Reviewed, UniProtKB/Swiss-Prot Q9C8H0 (AB12C_ARATH)

Last modified November 3, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ABC transporter C family member 12
      Short name=ABC transporter ABCC.12
      Short name=AtABCC12
    EC=3.6.3.44
Alternative name(s):
    Multidrug resistance-associated protein 13
    Glutathione S-conjugate-transporting ATPase 13
    ATP-energized glutathione S-conjugate pump 13
Gene names
Name: ABCC12
Synonyms: MRP12, MRP13
Ordered Locus Names: At1g30410
ORF Names: T4K22.13
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length1495 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Pump for glutathione S-conjugates By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.4

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

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Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14951495ABC transporter C family member 12
PRO_0000226084

Regions

Transmembrane38 – 5821 Potential
Transmembrane76 – 9621 Potential
Transmembrane110 – 13021 Potential
Transmembrane146 – 16621 Potential
Transmembrane173 – 19523 Potential
Transmembrane303 – 32321 Potential
Transmembrane337 – 35721 Potential
Transmembrane420 – 44021 Potential
Transmembrane441 – 46121 Potential
Transmembrane528 – 54821 Potential
Transmembrane558 – 57821 Potential
Transmembrane907 – 92721 Potential
Transmembrane949 – 96921 Potential
Transmembrane1042 – 106221 Potential
Transmembrane1140 – 116021 Potential
Transmembrane1166 – 118621 Potential
Domain303 – 583281ABC transmembrane type-1 1
Domain615 – 839225ABC transporter 1
Domain914 – 1198285ABC transmembrane type-1 2
Domain1235 – 1469235ABC transporter 2
Nucleotide binding650 – 6578ATP 1 Potential
Nucleotide binding1269 – 12768ATP 2 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q9C8H0-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D29EF05C6D6BDE13

FASTA1,495167,956
        10         20         30         40         50         60 
MGFEALNWYC KPVADGFWEK AVDGAFGAYT PCAIDSLVML VSHFVLLGLC FYRIWIIFHN 

        70         80         90        100        110        120 
TKAQIYVLRK KYYNCVLGLL ACYCVVEPVL RLVMGISLFD MDEETDFPPF EVASLMVEAF 

       130        140        150        160        170        180 
AWFSMLVLIG LETKQYVKEF RWYVRFGVLY VLVADAVLLD LVLPLKNSIN RTALYLFISS 

       190        200        210        220        230        240 
RCSQALFGIL LLIYIPELDP YPGYHIVNNE PLDNVEYDAL RGGEHICPER HASIFSRIYF 

       250        260        270        280        290        300 
GWITPLMQLG YRKPITEKDV WQLDKWDQTE TLIKRFQRCW TEESRRPKPW LLRALNNSLG 

       310        320        330        340        350        360 
GRFWLAGIFK IGNDLSQFVG PVILSHLLRS MQEGDPAWVG YVYAFIIFVG VTLGVLCEAQ 

       370        380        390        400        410        420 
YFQNVWRVGF RLRSTLVAAI FHKSLRLTHE ARKNFASGKV TNMITTDANA LQQISQQLHG 

       430        440        450        460        470        480 
LWSAPFRIIV SMILLYQQLG VASLFGSLIL FLLIPLQTLI ISKMRKLTKE GLQWTDKRVG 

       490        500        510        520        530        540 
ITNEILSSMD TVKCYAWEKS FESRIQGIRN EELSWFRKAQ LLSAFNSFIL NSIPVVVTVV 

       550        560        570        580        590        600 
SFGVFVLLGG DLTPARAFTS LSLFAVLRFP LNMLPNLLSQ VVNANVSLQR IEELLLSEER 

       610        620        630        640        650        660 
ILAQNPPLQP GTPAISIKNG YFSWDSKTTK PTLSDINLEI PVGTLVAIVG GTGEGKTSLI 

       670        680        690        700        710        720 
SAMLGELSHA ETTSVVIRGS VAYVPQVSWI FNATVRENIL FGSDFESERY WRAIDATALQ 

       730        740        750        760        770        780 
HDLDLLPGRD LTEIGERGVN ISGGQKQRVS MARAVYSNSD VYIFDDPLSA LDAHVAHQVF 

       790        800        810        820        830        840 
DSCMKDELRG KTRVLVTNQL HFLPLMDKII LVSEGMIKEE GTFVELSKSG ILFKKLMENA 

       850        860        870        880        890        900 
GKMDATQEVN TNDENILKLG PTVTVDVSER NLGSTKQGKR RRSVLIKQEE RETGIISWNV 

       910        920        930        940        950        960 
LMRYKEAVGG LWVVMILLAC YLATEVLRVS SSTWLSIWTD QSTSKNYSPG FYIVVYALLG 

       970        980        990       1000       1010       1020 
FGQVAVTFTN SFWLITSSLH AARRLHDAML SSILRAPMLF FHTNPTGRVI NRFSKDIGDI 

      1030       1040       1050       1060       1070       1080 
DRNVANLMNM FMNQLWQLLS TFALIGTVST ISLWAIMPLL ILFYAAYLYY QSTSREVRRL 

      1090       1100       1110       1120       1130       1140 
DSVTRSPIYA QFGEALNGLS SIRAYKAYDR MAKINGKSMD NNIRFTLANT SSNRWLTIRL 

      1150       1160       1170       1180       1190       1200 
ETLGGVMIWL TATFAVLQNG NTNNQAGFAS TMGLLLSYTL NITSLLSGVL RQASRAENSL 

      1210       1220       1230       1240       1250       1260 
NSVERVGNYI DLPSEATDII ENNRPVCGWP SGGSIKFEDV HLRYRPGLPP VLHGLTFFVS 

      1270       1280       1290       1300       1310       1320 
PSEKVGVVGR TGAGKSSMLN ALFRIVEVEK GRIMIDDCDV AKFGLTDVRR VLSIIPQSPV 

      1330       1340       1350       1360       1370       1380 
LFSGTVRFNI DPFSEHNDAG LWEALHRAHI KDVISRNPFG LDAEVCEGGE NFSVGQRQLL 

      1390       1400       1410       1420       1430       1440 
SLARALLRRS KILVLDEATA SVDVRTDSLI QRTIREEFKS CTMLVIAHRL NTIIDCDKIL 

      1450       1460       1470       1480       1490 
VLSSGQVLEY DSPQELLSRD TSAFFRMVHS TGPANAQYLS NLVFERRENG MSVGG

« Hide

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References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed: 11130712] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[3]"Multifunctionality of plant ABC transporters -- more than just detoxifiers."
Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.
Planta 214:345-355(2002) [PubMed: 11855639] [Abstract]
Cited for: GENE FAMILY.
[4]"Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana."
Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D., Martinoia E., Schulz B.
Planta 216:107-119(2002) [PubMed: 12430019] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Plant ABC proteins - a unified nomenclature and updated inventory."
Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.
Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AC025295 Genomic DNA. Translation: AAG51100.1.
IPIIPI00531700.
PIRE86428.

3D structure databases

HSSPHSSP built from PDB template 1R0W based on UniProtKB P26361.
ModBaseSearch...

Genome annotation databases

GenomeReviewsGene locus AT1G30410 in contig CT485782_GR.
NMPDRfig|3702.1.peg.3376.

Organism-specific databases

TAIRAt1g30410.

Phylogenomic databases

OMAITSSLHA.

Enzyme and pathway databases

BRENDA3.6.3.44. 302.

Gene expression databases

GenevestigatorQ9C8H0.
GermOnlineAT1G30410. Arabidopsis thaliana.

Family and domain databases

InterProIPR001140. ABC_TM_transpt.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
ProDomPD000006. ABC_transporter. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAB12C_ARATH
AccessionPrimary (citable) accession number: Q9C8H0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2001
Last modified: November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents