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Protein

Long chain acyl-CoA synthetase 3

Gene

LACS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Cofactori

Mg2+By similarity

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi228 – 239ATPSequence analysisAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • fatty acid metabolic process Source: UniProtKB

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G64400-MONOMER
MetaCyc:AT1G64400-MONOMER
UniPathwayiUPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
Long chain acyl-CoA synthetase 3 (EC:6.2.1.3)
Gene namesi
Name:LACS3
Ordered Locus Names:At1g64400
ORF Names:F15H21.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G64400
TAIRilocus:2014265 AT1G64400

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004014111 – 665Long chain acyl-CoA synthetase 3Add BLAST665

Proteomic databases

PaxDbiQ9C7W4
PRIDEiQ9C7W4

PTM databases

iPTMnetiQ9C7W4

Expressioni

Gene expression databases

ExpressionAtlasiQ9C7W4 baseline and differential
GenevisibleiQ9C7W4 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G64400.1

Structurei

3D structure databases

ProteinModelPortaliQ9C7W4
SMRiQ9C7W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni495 – 519Fatty acid-bindingSequence analysisAdd BLAST25

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
HOGENOMiHOG000159459
InParanoidiQ9C7W4
KOiK01897
OMAiECVMLCH
OrthoDBiEOG093604GF
PhylomeDBiQ9C7W4

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C7W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGRYIVEV EKGKQGVDGG SPSVGPVYRS IYAKDGFPEP PDDLVSAWDI
60 70 80 90 100
FRLSVEKSPN NPMLGRREIV DGKAGKYVWQ TYKEVHNVVI KLGNSIRTIG
110 120 130 140 150
VGKGDKCGIY GANSPEWIIS MEACNAHGLY CVPLYDTLGA GAIEFIICHA
160 170 180 190 200
EVSLAFAEEN KISELLKTAP KSTKYLKYIV SFGEVTNNQR VEAERHRLTI
210 220 230 240 250
YSWDQFLKLG EGKHYELPEK RRSDVCTIMY TSGTTGDPKG VLLTNESIIH
260 270 280 290 300
LLEGVKKLLK TIDEELTSKD VYLSYLPLAH IFDRVIEELC IYEAASIGFW
310 320 330 340 350
RGDVKILIED IAALKPTVFC AVPRVLERIY TGLQQKLSDG GFVKKKLFNF
360 370 380 390 400
AFKYKHKNME KGQPHEQASP IADKIVFKKV KEGLGGNVRL ILSGAAPLAA
410 420 430 440 450
HIESFLRVVA CAHVLQGYGL TESCGGTFVS IPNELSMLGT VGPPVPNVDI
460 470 480 490 500
RLESVPEMGY DALASNPRGE ICIRGKTLFS GYYKREDLTQ EVFIDGWLHT
510 520 530 540 550
GDVGEWQPDG AMKIIDRKKN IFKLSQGEYV AVENLENIYS HVAAIESIWV
560 570 580 590 600
YGNSYESYLV AVVCPSKIQI EHWAKEHKVS GDFESICRNQ KTKEFVLGEF
610 620 630 640 650
NRVAKDKKLK GFELIKGVHL DTVPFDMERD LITPSYKMKR PQLLKYYQKE
660
IDEMYKKNRE VQLRV
Length:665
Mass (Da):74,751
Last modified:June 1, 2001 - v1
Checksum:iB546A845F101DB6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503753 mRNA Translation: AAM28870.1
AC066689 Genomic DNA Translation: AAG51719.1
CP002684 Genomic DNA Translation: AEE34237.1
AY039935 mRNA Translation: AAK64039.1
AY079314 mRNA Translation: AAL85045.1
PIRiB96668
RefSeqiNP_176622.1, NM_105115.4
UniGeneiAt.24316

Genome annotation databases

EnsemblPlantsiAT1G64400.1; AT1G64400.1; AT1G64400
GeneIDi842748
GrameneiAT1G64400.1; AT1G64400.1; AT1G64400
KEGGiath:AT1G64400

Similar proteinsi

Entry informationi

Entry nameiLACS3_ARATH
AccessioniPrimary (citable) accession number: Q9C7W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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