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Protein

ABC transporter B family member 14

Gene

ABCB14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi407 – 414ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1041 – 1048ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G28010-MONOMER.
ReactomeiR-ATH-159418. Recycling of bile acids and salts.
R-ATH-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-ATH-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 14
Short name:
ABC transporter ABCB.14
Short name:
AtABCB14
Alternative name(s):
Multidrug resistance protein 12
P-glycoprotein 14
Gene namesi
Name:ABCB14
Synonyms:MDR12, PGP14
Ordered Locus Names:At1g28010
ORF Names:F13K9.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G28010.
TAIRilocus:2010444. AT1G28010.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei95 – 115HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei172 – 192HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei196 – 216HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei277 – 297HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei315 – 335HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei680 – 700HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei727 – 747HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei807 – 824HelicalPROSITE-ProRule annotationAdd BLAST18
Transmembranei830 – 850HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei915 – 935HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei949 – 969HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279231 – 1247ABC transporter B family member 14Add BLAST1247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1010N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1108N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9C7F2.

PTM databases

iPTMnetiQ9C7F2.

Expressioni

Gene expression databases

GenevisibleiQ9C7F2. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G28010.1.

Structurei

3D structure databases

ProteinModelPortaliQ9C7F2.
SMRiQ9C7F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 337ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST290
Domaini373 – 608ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini679 – 971ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST293
Domaini1006 – 1242ABC transporter 2PROSITE-ProRule annotationAdd BLAST237

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9C7F2.
KOiK05658.
OMAiNALMEGE.
OrthoDBiEOG093601EV.
PhylomeDBiQ9C7F2.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9C7F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNIEPPFSG NIHAETEVKK EEKKKMKKES VSLMGLFSAA DNVDYFLMFL
60 70 80 90 100
GGLGTCIHGG TLPLFFVFFG GMLDSLGKLS TDPNAISSRV SQNALYLVYL
110 120 130 140 150
GLVNLVSAWI GVACWMQTGE RQTARLRINY LKSILAKDIT FFDTEARDSN
160 170 180 190 200
FIFHISSDAI LVQDAIGDKT GHVLRYLCQF IAGFVIGFLS VWQLTLLTLG
210 220 230 240 250
VVPLIAIAGG GYAIVMSTIS EKSEAAYADA GKVAEEVMSQ VRTVYAFVGE
260 270 280 290 300
EKAVKSYSNS LKKALKLSKR SGLAKGLGVG LTYSLLFCAW ALLFWYASLL
310 320 330 340 350
VRHGKTNGAK AFTTILNVIY SGFALGQAVP SLSAISKGRV AAANIFKMIG
360 370 380 390 400
NNNLESSERL ENGTTLQNVV GKIEFCGVSF AYPSRPNMVF ENLSFTIHSG
410 420 430 440 450
KTFAFVGPSG SGKSTIISMV QRFYEPRSGE ILLDGNDIKN LKLKWLREQM
460 470 480 490 500
GLVSQEPALF ATTIASNILL GKEKANMDQI IEAAKAANAD SFIKSLPNGY
510 520 530 540 550
NTQVGEGGTQ LSGGQKQRIA IARAVLRNPK ILLLDEATSA LDAESEKIVQ
560 570 580 590 600
QALDNVMEKR TTIVIAHRLS TIRNVDKIVV LRDGQVRETG SHSELISRGG
610 620 630 640 650
DYATLVNCQD TEPQENLRSV MYESCRSQAG SYSSRRVFSS RRTSSFREDQ
660 670 680 690 700
EKTEKDSKGE DLISSSSMIW ELIKLNAPEW LYALLGSIGA VLAGSQPALF
710 720 730 740 750
SMGLAYVLTT FYSPFPSLIK REVDKVAIIF VGAGIVTAPI YILQHYFYTL
760 770 780 790 800
MGERLTSRVR LSLFSAILSN EIGWFDLDEN NTGSLTSILA ADATLVRSAI
810 820 830 840 850
ADRLSTIVQN LSLTITALAL AFFYSWRVAA VVTACFPLLI AASLTEQLFL
860 870 880 890 900
KGFGGDYTRA YSRATSLARE AISNIRTVAA FSAEKQISEQ FTCELSKPTK
910 920 930 940 950
SALLRGHISG FGYGLSQCLA FCSYALGLWY ISVLIKRNET NFEDSIKSFM
960 970 980 990 1000
VLLVTAYSVA ETLALTPDIV KGTQALGSVF RVLHRETEIP PDQPNSRLVT
1010 1020 1030 1040 1050
HIKGDIEFRN VSFAYPTRPE IAIFKNLNLR VSAGKSLAVV GPSGSGKSTV
1060 1070 1080 1090 1100
IGLIMRFYDP SNGNLCIDGH DIKSVNLRSL RKKLALVQQE PALFSTSIHE
1110 1120 1130 1140 1150
NIKYGNENAS EAEIIEAAKA ANAHEFISRM EEGYMTHVGD KGVQLSGGQK
1160 1170 1180 1190 1200
QRVAIARAVL KDPSVLLLDE ATSALDTSAE KQVQEALDKL MKGRTTILVA
1210 1220 1230 1240
HRLSTIRKAD TIVVLHKGKV VEKGSHRELV SKSDGFYKKL TSLQEAV
Length:1,247
Mass (Da):136,176
Last modified:June 1, 2001 - v1
Checksum:iC036DBD9C770DF1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069471 Genomic DNA. Translation: AAG51476.1.
CP002684 Genomic DNA. Translation: AEE30902.1.
PIRiF86405.
RefSeqiNP_174122.1. NM_102566.3.
UniGeneiAt.40954.
At.51796.

Genome annotation databases

EnsemblPlantsiAT1G28010.1; AT1G28010.1; AT1G28010.
GeneIDi839694.
GrameneiAT1G28010.1; AT1G28010.1; AT1G28010.
KEGGiath:AT1G28010.

Similar proteinsi

Entry informationi

Entry nameiAB14B_ARATH
AccessioniPrimary (citable) accession number: Q9C7F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families