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Protein

Putative CCR4-associated factor 1 homolog 4

Gene

CAF1-4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).By similarity

Catalytic activityi

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Divalent metal cation; catalyticBy similarity1
Metal bindingi31Divalent metal cation; catalyticBy similarity1
Metal bindingi145Divalent metal cation; catalyticBy similarity1
Metal bindingi218Divalent metal cation; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative CCR4-associated factor 1 homolog 4 (EC:3.1.13.4)
Gene namesi
Name:CAF1-4
Ordered Locus Names:At1g27890
ORF Names:F13K9.1, F28L5.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G27890
TAIRilocus:2010414 AT1G27890

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003715541 – 302Putative CCR4-associated factor 1 homolog 4Add BLAST302

Proteomic databases

PaxDbiQ9C6M9

PTM databases

iPTMnetiQ9C6M9

Interactioni

Subunit structurei

Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.By similarity

Protein-protein interaction databases

BioGridi24917, 1 interactor
STRINGi3702.AT1G27890.1

Structurei

3D structure databases

ProteinModelPortaliQ9C6M9
SMRiQ9C6M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CAF1 family.Curated

Phylogenomic databases

eggNOGiKOG0304 Eukaryota
COG5228 LUCA
HOGENOMiHOG000173077
InParanoidiQ9C6M9
KOiK12581
OMAiLNHAGAI
OrthoDBiEOG09360DRA
PhylomeDBiQ9C6M9

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006941 RNase_CAF1
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF04857 CAF1, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C6M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEVWRWNKE VEMDSIRDCL KHFSSIAIDT EFPGCLKETP MDASEEIRYR
60 70 80 90 100
DMKFNVDNTH LIQLGFTLFD RRGITKTWEI NLSDFNEHKC FKNDKSIAFL
110 120 130 140 150
KSNGLNLDKI GEEGIGIEEF FRDFSQILKE KDGKITWVNF QGSYDNAYLV
160 170 180 190 200
KGLTGGKPLP ETKEEFHETV EQLLGKFVFD VKKIAESCSG LSSRFGLQRI
210 220 230 240 250
ADVLQMKRVG KAHHAGSDSE LTARVFTKLT FDLLNSRKQC VRRVDHQQYQ
260 270 280 290 300
LEQQQLMMTR CYIPIPIPIP RPRSVMFAAH HPNPYFGGGY FGMPVQGRNY

VL
Length:302
Mass (Da):34,862
Last modified:June 1, 2001 - v1
Checksum:iF19BC314E98E1174
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069471 Genomic DNA Translation: AAG51471.1
AC079280 Genomic DNA Translation: AAG50583.1
CP002684 Genomic DNA Translation: AEE30888.1
PIRiB86404
RefSeqiNP_174110.1, NM_102554.2

Genome annotation databases

EnsemblPlantsiAT1G27890.1; AT1G27890.1; AT1G27890
GeneIDi839682
GrameneiAT1G27890.1; AT1G27890.1; AT1G27890
KEGGiath:AT1G27890

Similar proteinsi

Entry informationi

Entry nameiCAF1D_ARATH
AccessioniPrimary (citable) accession number: Q9C6M9
Secondary accession number(s): Q9C7G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health