Q9C6I4 (G2OX7_ARATH) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 67.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Gibberellin 2-beta-dioxygenase 7 EC=1.14.11.13 Alternative name(s): GA 2-oxidase 7 Gibberellin 2-beta-hydroxylase 7 Gibberellin 2-oxidase 7 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Protein attributes
| Sequence length | 336 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the 2-beta-hydroxylation of gibberellins (GA) precursors, rendering them unable to be converted to active GAs. Hydroxylates the C20-GA GA12 and GA53, but is not active on C19-GAs, like GA1, GA4, GA9 and GA20. Ref.3 |
| Catalytic activity | Gibberellin 1 + 2-oxoglutarate + O2 = 2-beta-hydroxygibberellin 1 + succinate + CO2. |
| Cofactor | Iron By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the iron/ascorbate-dependent oxidoreductase family. GA2OX subfamily. Contains 1 Fe2OG dioxygenase domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | gibberellin metabolic process Inferred from direct assay Ref.3. Source: TAIR response to salt stressInferred from genetic interaction. Source: TAIR |
| Molecular function | C-20 gibberellin 2-beta-dioxygenase activity Inferred from direct assay Ref.3. Source: TAIR metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 336 | 336 | Gibberellin 2-beta-dioxygenase 7 | PRO_0000067308 | |||||
Regions | |||||||||
| Domain | 191 – 291 | 101 | Fe2OG dioxygenase | ||||||
Sites | |||||||||
| Active site | 282 | 1 | Potential | ||||||
| Metal binding | 216 | 1 | Iron By similarity | ||||||
| Metal binding | 218 | 1 | Iron By similarity | ||||||
| Metal binding | 272 | 1 | Iron By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W.Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia. |
| [3] | "Overexpression of a novel class of gibberellin 2-oxidases decreases gibberellin levels and creates dwarf plants." Schomburg F.M., Bizzell C.M., Lee D.J., Zeevaart J.A.D., Amasino R.M. Plant Cell 15:151-163(2003) [PubMed: 12509528] [Abstract] Cited for: FUNCTION, CHARACTERIZATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC079284 Genomic DNA. Translation: AAG50945.1. CP002684 Genomic DNA. Translation: AEE32606.1. |
| IPI | IPI00519781. |
| PIR | G96546. |
| RefSeq | NP_175509.1. NM_103976.1. |
| UniGene | At.52121. |
3D structure databases | |
| ProteinModelPortal | Q9C6I4. |
| SMR | Q9C6I4. Positions 9-321. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9C6I4. |
Proteomic databases | |
| PRIDE | Q9C6I4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblPlants | AT1G50960.1; AT1G50960.1; AT1G50960. |
| GeneID | 841518. |
| GenomeReviews | Gene locus AT1G50960 in contig CT485782_GR. |
| KEGG | ath:AT1G50960. |
| NMPDR | fig|3702.1.peg.4566. |
Organism-specific databases | |
| TAIR | At1g50960. |
Phylogenomic databases | |
| eggNOG | KOG0143. |
| GeneTree | EPGT00050000009705. |
| HOGENOM | HBG592995. |
| InParanoid | Q9C6I4. |
| OMA | RVISPAN. |
| PhylomeDB | Q9C6I4. |
| ProtClustDB | CLSN2912822. |
Enzyme and pathway databases | |
| BioCyc | ARA:AT1G50960-MONOMER. MetaCyc:AT1G50960-MONOMER. |
Gene expression databases | |
| Genevestigator | Q9C6I4. |
| GermOnline | AT1G50960. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR005123. Oxoglutarate/Fe-dep_oxygenase. [Graphical view] |
| Pfam | PF03171. 2OG-FeII_Oxy. 1 hit. [Graphical view] |
| PROSITE | PS51471. FE2OG_OXY. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G2OX7_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9C6I4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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