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Protein

Structural maintenance of chromosomes protein 2-1

Gene

SMC2-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • transporter activity Source: TAIR

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Meiosis, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-2299718 Condensation of Prophase Chromosomes
R-ATH-2514853 Condensation of Prometaphase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 2-1
Short name:
AtSMC2-1
Alternative name(s):
Chromosome-associated protein E-1
Short name:
AtCAP-E1
Protein TITAN 3
Gene namesi
Name:SMC2-1
Synonyms:CAP-E1, TTN3
Ordered Locus Names:At5g62410
ORF Names:MMI9.19, MMI9.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G62410
TAIRilocus:2167973 AT5G62410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848941 – 1175Structural maintenance of chromosomes protein 2-1Add BLAST1175

Proteomic databases

PaxDbiQ9C5Y4

PTM databases

iPTMnetiQ9C5Y4

Expressioni

Tissue specificityi

Highly expressed in roots and young floral buds.1 Publication

Gene expression databases

ExpressionAtlasiQ9C5Y4 baseline and differential
GenevisibleiQ9C5Y4 AT

Interactioni

Subunit structurei

Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: CAPH, CAPD2 and CAPG.

Protein-protein interaction databases

STRINGi3702.AT5G62410.1

Structurei

3D structure databases

ProteinModelPortaliQ9C5Y4
SMRiQ9C5Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 1161Zinc-hookAdd BLAST1160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni509 – 672Flexible hingeAdd BLAST164

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili172 – 508Sequence analysisAdd BLAST337
Coiled coili673 – 1028Sequence analysisAdd BLAST356

Domaini

The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.

Sequence similaritiesi

Belongs to the SMC family. SMC2 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0933 Eukaryota
COG1196 LUCA
HOGENOMiHOG000163792
InParanoidiQ9C5Y4
KOiK06674
OMAiGANKVWR
OrthoDBiEOG093600ZC
PhylomeDBiQ9C5Y4

Family and domain databases

CDDicd03273 ABC_SMC2_euk, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR027120 Smc2_ABC
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF75553 SSF75553, 1 hit

Sequencei

Sequence statusi: Complete.

Q9C5Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIKEICLEG FKSYATRTVV SGFDPHFNAI TGLNGSGKSN ILDSICFVLG
60 70 80 90 100
ITNLQQVRAA NLQELVYKQG QAGITKATVS VTFDNSERHR SPLGYEEHPE
110 120 130 140 150
ITVTRQIVVG GRNKYLINGK LAQPSQVQNL FHSVQLNVNN PHFLIMQGRI
160 170 180 190 200
TKVLNMKPPE ILSMLEEAAG TRMYENKKEA ALKTLEKKQT KVDEINKLLD
210 220 230 240 250
HEILPALEKL RKEKSQYMQW ANGNAELDRL RRFCIAFEYV QAEKIRDNAV
260 270 280 290 300
LGVGEMKAKL GKIDAETEKT QEEIQEFEKQ IKALTQAKEA SMGGEVKTLS
310 320 330 340 350
EKVDSLAQEM TRESSKLNNK EDTLLGEKEN VEKIVHSIED LKKSVKERAA
360 370 380 390 400
AVKKSEEGAA DLKQRFQELS TTLEECEKEH QGVLAGKSSG DEEKCLEDQL
410 420 430 440 450
RDAKIAVGTA GTELKQLKTK IEHCEKELKE RKSQLMSKLE EAIEVENELG
460 470 480 490 500
ARKNDVEHVK KALESIPYNE GQMEALEKDR GAELEVVQRL EDKVRGLSAQ
510 520 530 540 550
LANFQFTYSD PVRNFDRSKV KGVVAKLIKV KDRSSMTALE VTAGGKLYDV
560 570 580 590 600
VVDSEDTGKQ LLQNGALRRR VTIIPLNKIQ SYVVQPRVQQ ATARLVGKDN
610 620 630 640 650
AELALSLVGY SDELKNAMEY VFGSTFVCKT TDVAKEVAFN RDIRTPSVTL
660 670 680 690 700
EGDIFQPSGL LTGGSRKGGG DRLRKLHDLA EAESELQGHQ KRLADVESQI
710 720 730 740 750
KELQPLQMKF TDVYAQLELK TYDLSLFLKR AEQNEHHKLG EAVKKLEEEL
760 770 780 790 800
EEAKSQIKEK ELAYKNCFDA VSKLENSIKD HDKNREGRLK DLEKNIKTIK
810 820 830 840 850
AQMQAASKDL KSHENEKEKL VMEEEAMKQE QSSLESHLTS LETQISTLTS
860 870 880 890 900
EVDEQRAKVD ALQKIHDESL AELKLIHAKM KECDTQISGF VTDQEKCLQK
910 920 930 940 950
LSDMKLERKK LENEVVRMET DHKDCSVKVD KLVEKHTWIA SEKQLFGKGG
960 970 980 990 1000
TDYDFESCDP YVAREKLEKL QSDQSGLEKR VNKKVMAMFE KAEDEYNALI
1010 1020 1030 1040 1050
SKKNTIENDK SKITKVIEEL DEKKKETLKV TWVKVNQDFG SIFSTLLPGT
1060 1070 1080 1090 1100
MAKLEPPEDG NFLDGLEVRV AFGKVWKQSL SELSGGQRSL LALSLILALL
1110 1120 1130 1140 1150
LFKPAPLYIL DEVDAALDLS HTQNIGRMIR AHFPHSQFIV VSLKEGMFNN
1160 1170
ANVLFRTKFV DGVSTVQRTV TKQTK
Length:1,175
Mass (Da):132,600
Last modified:May 1, 2007 - v2
Checksum:i51EA64A11C3FFF62
GO

Sequence cautioni

The sequence AAG27593 differs from that shown. Reason: Frameshift at positions 168 and 174.Curated
The sequence AAK58634 differs from that shown. Reason: Frameshift at positions 168 and 174.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107I → V in AAK58634 (PubMed:11846874).Curated1
Sequence conflicti107I → V in AAG27593 (PubMed:11846874).Curated1
Sequence conflicti213E → K in AAG53093 (PubMed:12783798).Curated1
Sequence conflicti254G → GVG in AAK58634 (PubMed:11846874).Curated1
Sequence conflicti254G → GVG in AAG27593 (PubMed:11846874).Curated1
Sequence conflicti439L → R in AAK58634 (PubMed:11846874).Curated1
Sequence conflicti439L → R in AAG27593 (PubMed:11846874).Curated1
Sequence conflicti439L → R in AAG53093 (PubMed:12783798).Curated1
Sequence conflicti602E → G in AAG53093 (PubMed:12783798).Curated1
Sequence conflicti965E → V in AAK58634 (PubMed:11846874).Curated1
Sequence conflicti965E → V in AAG27593 (PubMed:11846874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271730 Genomic DNA Translation: AAG27593.2 Frameshift.
AF271731 mRNA Translation: AAK58634.1 Frameshift.
AF306547 mRNA Translation: AAG53093.1
AB015469, AB019235 Genomic DNA Translation: BAB11491.1
CP002688 Genomic DNA Translation: AED97605.1
RefSeqiNP_201047.1, NM_125635.3
UniGeneiAt.19029

Genome annotation databases

EnsemblPlantsiAT5G62410.1; AT5G62410.1; AT5G62410
GeneIDi836362
GrameneiAT5G62410.1; AT5G62410.1; AT5G62410
KEGGiath:AT5G62410

Similar proteinsi

Entry informationi

Entry nameiSMC21_ARATH
AccessioniPrimary (citable) accession number: Q9C5Y4
Secondary accession number(s): Q9FJK1, Q9FUY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome