Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9C5X9

- HAC1_ARATH

UniProt

Q9C5X9 - HAC1_ARATH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone acetyltransferase HAC1

Gene

HAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1279 – 12791Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri629 – 70981TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri989 – 106678PHD-typeAdd
BLAST
Zinc fingeri1398 – 144548ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1518 – 156649ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1579 – 166284TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. transcription cofactor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G79000-MONOMER.
ARA:GQT-2142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC1 (EC:2.3.1.481 Publication)
Gene namesi
Name:HAC1
Synonyms:PCAT2
Ordered Locus Names:At1g79000
ORF Names:YUP8H12R.38, YUP8H12R_22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G79000.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1159 – 11613FAY → AAA: Abolishes acetyltransferase activity. 1 Publication
Mutagenesisi1279 – 12802WY → AA: Abolishes acetyltransferase activity. 1 Publication
Mutagenesisi1283 – 12842ML → AA: 3-fold decrease in acetyltransferase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16971697Histone acetyltransferase HAC1PRO_0000269740Add
BLAST

Proteomic databases

PaxDbiQ9C5X9.
PRIDEiQ9C5X9.

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

ExpressionAtlasiQ9C5X9. baseline and differential.
GenevestigatoriQ9C5X9.

Interactioni

Protein-protein interaction databases

MINTiMINT-8059460.

Structurei

3D structure databases

ProteinModelPortaliQ9C5X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1081 – 1517437CBP/p300-type HATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1204 – 12063Acetyl-CoA bindingBy similarity
Regioni1223 – 12242Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi266 – 30136Gln-richAdd
BLAST
Compositional biasi399 – 524126Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.Curated
Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri629 – 70981TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri989 – 106678PHD-typeAdd
BLAST
Zinc fingeri1398 – 144548ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1518 – 156649ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1579 – 166284TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG326839.
HOGENOMiHOG000242057.
InParanoidiQ9C5X9.
KOiK04498.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C5X9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVQAHMSGQ VSNQGTMSQQ NGNSQMQNLV GGGSAPATGA GLGPSRVSPV
60 70 80 90 100
DNDILKLRQA MRIRIFNILQ QKQPSPADEA SKAKYMDVAR RLEEGLFKIA
110 120 130 140 150
NTKEDYVNPS TLEPRLASLI KGRQLNNYNQ RHANSSSVGT MIPTPGLQHS
160 170 180 190 200
GGNPNLMITS SGDATMAGSN NITTSAMNTG NLLNSGGMLG GNLSNGYQHS
210 220 230 240 250
SSNFGLGSGG NMSSMSSQRN TGQMMPTPGF VNSSTNNNSN NGQSYLSVEA
260 270 280 290 300
SNNSGGFSTA PMMVPQTQQQ QLRQDIGGQN SRMLQNHGSQ MGVGLRPGMQ
310 320 330 340 350
QKLSNVSNSS INGGVGMNAK SVDSGTSYTN PIRNSQQAYD NLQRSGMQGD
360 370 380 390 400
GYGTNNSDPF GSGNLYGAVT SVGMMTNTQN ANTASFQAVS RTSSSLSHQQ
410 420 430 440 450
QQFQQQPNRF QQQPNQFHQQ QQQFLHQQQL KQQSQQQQRF ISHDAFGQNN
460 470 480 490 500
VASDMVTHVK HEPGMENPSE SIHSQTPEQF QLSQFQNQYQ NNAEDRHAGS
510 520 530 540 550
QILPVTSQSD MCTSVPQNSQ QIQQMLHPHS MASDSVNGFS NLSVGVKTES
560 570 580 590 600
GMRGHWQSQS QEHTQMSNSM SNERHIQEDF RQRMSGTDEA QPNNMSGGSI
610 620 630 640 650
IGQNRVSTTS ESLNPQNPTA TTCRNGNGNR DPRFKNQQKW LLFLRHARHC
660 670 680 690 700
KAPEGKCPDR NCVTVQKLWK HMDSCAAPQC SYPRCLPTKT LINHHRSCKE
710 720 730 740 750
PNCPVCIPVK AYLQQQANAR SLARLKNETD AARSVNGGGI SSDAVQTSAG
760 770 780 790 800
AKSCTSPGAD ISGHLQPSLK RLKVEQSSQP VDVETESCKS SVVSVTEAQS
810 820 830 840 850
SQYAERKDHK HSDVRAPSKY FEVKAEVSDF SVQTRPGFKD TKIGIAENIP
860 870 880 890 900
KQRPVSQPDK QDLSDVSPMQ ETTKVEKEPE SLKKENLAES TEHTSKSGKP
910 920 930 940 950
EIKGVSLTEL FTPEQVREHI RGLRQWVGQS KAKAEKNQAM EHSMSENSCQ
960 970 980 990 1000
LCAVEKLTFE PPPIYCTPCG ARIKRNAMYY TVGAGDTRHY FCIPCYNESR
1010 1020 1030 1040 1050
GDTILAEGTP MPKARLEKKK NDEETEEWWV QCDKCEAWQH QICALFNGRR
1060 1070 1080 1090 1100
NDGGQAEYTC PYCFIAEVEQ SKRKPLPQSA VLGAKDLPRT ILSDHIEQRL
1110 1120 1130 1140 1150
FKRLKQERTE RARAQGKSYD EIPTAESLVI RVVSSVDKKL EVKPRFLEIF
1160 1170 1180 1190 1200
REDSYPTEFA YKSKVVLLFQ KIEGVEVCLF GMYVQEFGSE CAFPNQRRVY
1210 1220 1230 1240 1250
LSYLDSVKYF RPEVRSYNGE ALRTFVYHEI LIGYLEYCKL RGFTSCYIWA
1260 1270 1280 1290 1300
CPPLKGEDYI LYCHPEIQKT PKSDKLREWY LAMLRKASKE GIVAETINLY
1310 1320 1330 1340 1350
DHFFMQTGEC RAKVTAARLP YFDGDYWPGA AEDLIYQMSQ EEDGRKGNKK
1360 1370 1380 1390 1400
GMLKKTITKR ALKASGQTDL SGNASKDLLL MHRLGETIHP MKEDFIMVHL
1410 1420 1430 1440 1450
QPSCTHCCIL MVSGNRWVCS QCKHFQICDK CYEAEQRRED RERHPVNFKD
1460 1470 1480 1490 1500
KHALYPVEIM DIPADTRDKD EILESEFFDT RQAFLSLCQG NHYQYDTLRR
1510 1520 1530 1540 1550
AKHSSMMVLY HLHNPTAPAF VTTCNACHLD IETGQGWRCE VCPDYDVCNA
1560 1570 1580 1590 1600
CFSRDGGVNH PHKLTNHPSL ADQNAQNKEA RQLRVLQLRK MLDLLVHASQ
1610 1620 1630 1640 1650
CRSAHCQYPN CRKVKGLFRH GINCKVRASG GCVLCKKMWY LLQLHARACK
1660 1670 1680 1690
ESECHVPRCR DLKEHLRRLQ QQSDSRRRAA VMEMMRQRAA EVAGGSG
Length:1,697
Mass (Da):190,045
Last modified:May 31, 2011 - v2
Checksum:i3B735C2DF863CDB0
GO
Isoform 2 (identifier: Q9C5X9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1661-1697: Missing.

Note: Incomplete sequence.

Show »
Length:1,660
Mass (Da):185,837
Checksum:i69BF7EDE6D8B6A13
GO

Sequence cautioni

The sequence AAC17068.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1661 – 169737Missing in isoform 2. 1 PublicationVSP_041112Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002986 Genomic DNA. Translation: AAC17068.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36191.1.
AF323954 mRNA. Translation: AAG60059.1.
PIRiT01055.
RefSeqiNP_565197.3. NM_106550.3. [Q9C5X9-1]
UniGeneiAt.21972.

Genome annotation databases

EnsemblPlantsiAT1G79000.1; AT1G79000.1; AT1G79000. [Q9C5X9-1]
AT1G79000.2; AT1G79000.2; AT1G79000.
GeneIDi844241.
KEGGiath:AT1G79000.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002986 Genomic DNA. Translation: AAC17068.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE36191.1 .
AF323954 mRNA. Translation: AAG60059.1 .
PIRi T01055.
RefSeqi NP_565197.3. NM_106550.3. [Q9C5X9-1 ]
UniGenei At.21972.

3D structure databases

ProteinModelPortali Q9C5X9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8059460.

Proteomic databases

PaxDbi Q9C5X9.
PRIDEi Q9C5X9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G79000.1 ; AT1G79000.1 ; AT1G79000 . [Q9C5X9-1 ]
AT1G79000.2 ; AT1G79000.2 ; AT1G79000 .
GeneIDi 844241.
KEGGi ath:AT1G79000.

Organism-specific databases

TAIRi AT1G79000.

Phylogenomic databases

eggNOGi NOG326839.
HOGENOMi HOG000242057.
InParanoidi Q9C5X9.
KOi K04498.

Enzyme and pathway databases

BioCyci ARA:AT1G79000-MONOMER.
ARA:GQT-2142-MONOMER.

Gene expression databases

ExpressionAtlasi Q9C5X9. baseline and differential.
Genevestigatori Q9C5X9.

Family and domain databases

Gene3Di 1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEi PS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
    Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
    Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-1660 (ISOFORM 2), MUTAGENESIS OF 1159-PHE--TYR-1161; 1279-TRP-TYR-1280 AND 1283-MET-LEU-1284, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, CATALYTIC ACTIVITY.
  4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiHAC1_ARATH
AccessioniPrimary (citable) accession number: Q9C5X9
Secondary accession number(s): O64548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 31, 2011
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3