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Q9C5X9

- HAC1_ARATH

UniProt

Q9C5X9 - HAC1_ARATH

Protein

Histone acetyltransferase HAC1

Gene

HAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (31 May 2011)
      Previous versions | rss
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    Functioni

    Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri629 – 70981TAZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri989 – 106678PHD-typeAdd
    BLAST
    Zinc fingeri1398 – 144548ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1518 – 156649ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1579 – 166284TAZ-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. transcription cofactor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT1G79000-MONOMER.
    ARA:GQT-2142-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase HAC1 (EC:2.3.1.48)
    Gene namesi
    Name:HAC1
    Synonyms:PCAT2
    Ordered Locus Names:At1g79000
    ORF Names:YUP8H12R.38, YUP8H12R_22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G79000.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1159 – 11613FAY → AAA: Abolishes acetyltransferase activity. 1 Publication
    Mutagenesisi1279 – 12802WY → AA: Abolishes acetyltransferase activity. 1 Publication
    Mutagenesisi1283 – 12842ML → AA: 3-fold decrease in acetyltransferase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16971697Histone acetyltransferase HAC1PRO_0000269740Add
    BLAST

    Proteomic databases

    PaxDbiQ9C5X9.
    PRIDEiQ9C5X9.

    Expressioni

    Tissue specificityi

    Rosette leaves, stems and flowers.1 Publication

    Developmental stagei

    Expressed in young seedlings.1 Publication

    Gene expression databases

    ArrayExpressiQ9C5X9.
    GenevestigatoriQ9C5X9.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8059460.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9C5X9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi266 – 30136Gln-richAdd
    BLAST
    Compositional biasi399 – 524126Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.Curated
    Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
    Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri629 – 70981TAZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri989 – 106678PHD-typeAdd
    BLAST
    Zinc fingeri1398 – 144548ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1518 – 156649ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1579 – 166284TAZ-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG326839.
    HOGENOMiHOG000242057.
    InParanoidiQ9C5X9.
    KOiK04498.

    Family and domain databases

    Gene3Di1.20.1020.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF08214. KAT11. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 2 hits.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9C5X9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNVQAHMSGQ VSNQGTMSQQ NGNSQMQNLV GGGSAPATGA GLGPSRVSPV     50
    DNDILKLRQA MRIRIFNILQ QKQPSPADEA SKAKYMDVAR RLEEGLFKIA 100
    NTKEDYVNPS TLEPRLASLI KGRQLNNYNQ RHANSSSVGT MIPTPGLQHS 150
    GGNPNLMITS SGDATMAGSN NITTSAMNTG NLLNSGGMLG GNLSNGYQHS 200
    SSNFGLGSGG NMSSMSSQRN TGQMMPTPGF VNSSTNNNSN NGQSYLSVEA 250
    SNNSGGFSTA PMMVPQTQQQ QLRQDIGGQN SRMLQNHGSQ MGVGLRPGMQ 300
    QKLSNVSNSS INGGVGMNAK SVDSGTSYTN PIRNSQQAYD NLQRSGMQGD 350
    GYGTNNSDPF GSGNLYGAVT SVGMMTNTQN ANTASFQAVS RTSSSLSHQQ 400
    QQFQQQPNRF QQQPNQFHQQ QQQFLHQQQL KQQSQQQQRF ISHDAFGQNN 450
    VASDMVTHVK HEPGMENPSE SIHSQTPEQF QLSQFQNQYQ NNAEDRHAGS 500
    QILPVTSQSD MCTSVPQNSQ QIQQMLHPHS MASDSVNGFS NLSVGVKTES 550
    GMRGHWQSQS QEHTQMSNSM SNERHIQEDF RQRMSGTDEA QPNNMSGGSI 600
    IGQNRVSTTS ESLNPQNPTA TTCRNGNGNR DPRFKNQQKW LLFLRHARHC 650
    KAPEGKCPDR NCVTVQKLWK HMDSCAAPQC SYPRCLPTKT LINHHRSCKE 700
    PNCPVCIPVK AYLQQQANAR SLARLKNETD AARSVNGGGI SSDAVQTSAG 750
    AKSCTSPGAD ISGHLQPSLK RLKVEQSSQP VDVETESCKS SVVSVTEAQS 800
    SQYAERKDHK HSDVRAPSKY FEVKAEVSDF SVQTRPGFKD TKIGIAENIP 850
    KQRPVSQPDK QDLSDVSPMQ ETTKVEKEPE SLKKENLAES TEHTSKSGKP 900
    EIKGVSLTEL FTPEQVREHI RGLRQWVGQS KAKAEKNQAM EHSMSENSCQ 950
    LCAVEKLTFE PPPIYCTPCG ARIKRNAMYY TVGAGDTRHY FCIPCYNESR 1000
    GDTILAEGTP MPKARLEKKK NDEETEEWWV QCDKCEAWQH QICALFNGRR 1050
    NDGGQAEYTC PYCFIAEVEQ SKRKPLPQSA VLGAKDLPRT ILSDHIEQRL 1100
    FKRLKQERTE RARAQGKSYD EIPTAESLVI RVVSSVDKKL EVKPRFLEIF 1150
    REDSYPTEFA YKSKVVLLFQ KIEGVEVCLF GMYVQEFGSE CAFPNQRRVY 1200
    LSYLDSVKYF RPEVRSYNGE ALRTFVYHEI LIGYLEYCKL RGFTSCYIWA 1250
    CPPLKGEDYI LYCHPEIQKT PKSDKLREWY LAMLRKASKE GIVAETINLY 1300
    DHFFMQTGEC RAKVTAARLP YFDGDYWPGA AEDLIYQMSQ EEDGRKGNKK 1350
    GMLKKTITKR ALKASGQTDL SGNASKDLLL MHRLGETIHP MKEDFIMVHL 1400
    QPSCTHCCIL MVSGNRWVCS QCKHFQICDK CYEAEQRRED RERHPVNFKD 1450
    KHALYPVEIM DIPADTRDKD EILESEFFDT RQAFLSLCQG NHYQYDTLRR 1500
    AKHSSMMVLY HLHNPTAPAF VTTCNACHLD IETGQGWRCE VCPDYDVCNA 1550
    CFSRDGGVNH PHKLTNHPSL ADQNAQNKEA RQLRVLQLRK MLDLLVHASQ 1600
    CRSAHCQYPN CRKVKGLFRH GINCKVRASG GCVLCKKMWY LLQLHARACK 1650
    ESECHVPRCR DLKEHLRRLQ QQSDSRRRAA VMEMMRQRAA EVAGGSG 1697
    Length:1,697
    Mass (Da):190,045
    Last modified:May 31, 2011 - v2
    Checksum:i3B735C2DF863CDB0
    GO
    Isoform 2 (identifier: Q9C5X9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1661-1697: Missing.

    Note: Incomplete sequence.

    Show »
    Length:1,660
    Mass (Da):185,837
    Checksum:i69BF7EDE6D8B6A13
    GO

    Sequence cautioni

    The sequence AAC17068.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1661 – 169737Missing in isoform 2. 1 PublicationVSP_041112Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002986 Genomic DNA. Translation: AAC17068.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE36191.1.
    AF323954 mRNA. Translation: AAG60059.1.
    PIRiT01055.
    RefSeqiNP_565197.3. NM_106550.3. [Q9C5X9-1]
    UniGeneiAt.21972.

    Genome annotation databases

    EnsemblPlantsiAT1G79000.1; AT1G79000.1; AT1G79000. [Q9C5X9-1]
    AT1G79000.2; AT1G79000.2; AT1G79000.
    GeneIDi844241.
    KEGGiath:AT1G79000.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    PlantsUBQ

    A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002986 Genomic DNA. Translation: AAC17068.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE36191.1 .
    AF323954 mRNA. Translation: AAG60059.1 .
    PIRi T01055.
    RefSeqi NP_565197.3. NM_106550.3. [Q9C5X9-1 ]
    UniGenei At.21972.

    3D structure databases

    ProteinModelPortali Q9C5X9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8059460.

    Proteomic databases

    PaxDbi Q9C5X9.
    PRIDEi Q9C5X9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G79000.1 ; AT1G79000.1 ; AT1G79000 . [Q9C5X9-1 ]
    AT1G79000.2 ; AT1G79000.2 ; AT1G79000 .
    GeneIDi 844241.
    KEGGi ath:AT1G79000.

    Organism-specific databases

    TAIRi AT1G79000.

    Phylogenomic databases

    eggNOGi NOG326839.
    HOGENOMi HOG000242057.
    InParanoidi Q9C5X9.
    KOi K04498.

    Enzyme and pathway databases

    BioCyci ARA:AT1G79000-MONOMER.
    ARA:GQT-2142-MONOMER.

    Gene expression databases

    ArrayExpressi Q9C5X9.
    Genevestigatori Q9C5X9.

    Family and domain databases

    Gene3Di 1.20.1020.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF08214. KAT11. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 2 hits.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
      Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
      Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-1660 (ISOFORM 2), MUTAGENESIS OF 1159-PHE--TYR-1161; 1279-TRP-TYR-1280 AND 1283-MET-LEU-1284, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, CATALYTIC ACTIVITY.
    4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiHAC1_ARATH
    AccessioniPrimary (citable) accession number: Q9C5X9
    Secondary accession number(s): O64548
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3