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Q9C5X9

- HAC1_ARATH

UniProt

Q9C5X9 - HAC1_ARATH

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Protein
Histone acetyltransferase HAC1
Gene
HAC1, PCAT2, At1g79000, YUP8H12R.38, YUP8H12R_22
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri629 – 70981TAZ-type 1
Add
BLAST
Zinc fingeri989 – 106678PHD-type
Add
BLAST
Zinc fingeri1398 – 144548ZZ-type 1
Add
BLAST
Zinc fingeri1518 – 156649ZZ-type 2
Add
BLAST
Zinc fingeri1579 – 166284TAZ-type 2
Add
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. transcription cofactor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G79000-MONOMER.
ARA:GQT-2142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC1 (EC:2.3.1.48)
Gene namesi
Name:HAC1
Synonyms:PCAT2
Ordered Locus Names:At1g79000
ORF Names:YUP8H12R.38, YUP8H12R_22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G79000.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1159 – 11613FAY → AAA: Abolishes acetyltransferase activity.
Mutagenesisi1279 – 12802WY → AA: Abolishes acetyltransferase activity.
Mutagenesisi1283 – 12842ML → AA: 3-fold decrease in acetyltransferase activity.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16971697Histone acetyltransferase HAC1
PRO_0000269740Add
BLAST

Proteomic databases

PaxDbiQ9C5X9.
PRIDEiQ9C5X9.

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

ArrayExpressiQ9C5X9.
GenevestigatoriQ9C5X9.

Interactioni

Protein-protein interaction databases

MINTiMINT-8059460.

Structurei

3D structure databases

ProteinModelPortaliQ9C5X9.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi266 – 30136Gln-rich
Add
BLAST
Compositional biasi399 – 524126Gln-rich
Add
BLAST

Sequence similaritiesi

Contains 2 ZZ-type zinc fingers.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG326839.
HOGENOMiHOG000242057.
InParanoidiQ9C5X9.
KOiK04498.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9C5X9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNVQAHMSGQ VSNQGTMSQQ NGNSQMQNLV GGGSAPATGA GLGPSRVSPV     50
DNDILKLRQA MRIRIFNILQ QKQPSPADEA SKAKYMDVAR RLEEGLFKIA 100
NTKEDYVNPS TLEPRLASLI KGRQLNNYNQ RHANSSSVGT MIPTPGLQHS 150
GGNPNLMITS SGDATMAGSN NITTSAMNTG NLLNSGGMLG GNLSNGYQHS 200
SSNFGLGSGG NMSSMSSQRN TGQMMPTPGF VNSSTNNNSN NGQSYLSVEA 250
SNNSGGFSTA PMMVPQTQQQ QLRQDIGGQN SRMLQNHGSQ MGVGLRPGMQ 300
QKLSNVSNSS INGGVGMNAK SVDSGTSYTN PIRNSQQAYD NLQRSGMQGD 350
GYGTNNSDPF GSGNLYGAVT SVGMMTNTQN ANTASFQAVS RTSSSLSHQQ 400
QQFQQQPNRF QQQPNQFHQQ QQQFLHQQQL KQQSQQQQRF ISHDAFGQNN 450
VASDMVTHVK HEPGMENPSE SIHSQTPEQF QLSQFQNQYQ NNAEDRHAGS 500
QILPVTSQSD MCTSVPQNSQ QIQQMLHPHS MASDSVNGFS NLSVGVKTES 550
GMRGHWQSQS QEHTQMSNSM SNERHIQEDF RQRMSGTDEA QPNNMSGGSI 600
IGQNRVSTTS ESLNPQNPTA TTCRNGNGNR DPRFKNQQKW LLFLRHARHC 650
KAPEGKCPDR NCVTVQKLWK HMDSCAAPQC SYPRCLPTKT LINHHRSCKE 700
PNCPVCIPVK AYLQQQANAR SLARLKNETD AARSVNGGGI SSDAVQTSAG 750
AKSCTSPGAD ISGHLQPSLK RLKVEQSSQP VDVETESCKS SVVSVTEAQS 800
SQYAERKDHK HSDVRAPSKY FEVKAEVSDF SVQTRPGFKD TKIGIAENIP 850
KQRPVSQPDK QDLSDVSPMQ ETTKVEKEPE SLKKENLAES TEHTSKSGKP 900
EIKGVSLTEL FTPEQVREHI RGLRQWVGQS KAKAEKNQAM EHSMSENSCQ 950
LCAVEKLTFE PPPIYCTPCG ARIKRNAMYY TVGAGDTRHY FCIPCYNESR 1000
GDTILAEGTP MPKARLEKKK NDEETEEWWV QCDKCEAWQH QICALFNGRR 1050
NDGGQAEYTC PYCFIAEVEQ SKRKPLPQSA VLGAKDLPRT ILSDHIEQRL 1100
FKRLKQERTE RARAQGKSYD EIPTAESLVI RVVSSVDKKL EVKPRFLEIF 1150
REDSYPTEFA YKSKVVLLFQ KIEGVEVCLF GMYVQEFGSE CAFPNQRRVY 1200
LSYLDSVKYF RPEVRSYNGE ALRTFVYHEI LIGYLEYCKL RGFTSCYIWA 1250
CPPLKGEDYI LYCHPEIQKT PKSDKLREWY LAMLRKASKE GIVAETINLY 1300
DHFFMQTGEC RAKVTAARLP YFDGDYWPGA AEDLIYQMSQ EEDGRKGNKK 1350
GMLKKTITKR ALKASGQTDL SGNASKDLLL MHRLGETIHP MKEDFIMVHL 1400
QPSCTHCCIL MVSGNRWVCS QCKHFQICDK CYEAEQRRED RERHPVNFKD 1450
KHALYPVEIM DIPADTRDKD EILESEFFDT RQAFLSLCQG NHYQYDTLRR 1500
AKHSSMMVLY HLHNPTAPAF VTTCNACHLD IETGQGWRCE VCPDYDVCNA 1550
CFSRDGGVNH PHKLTNHPSL ADQNAQNKEA RQLRVLQLRK MLDLLVHASQ 1600
CRSAHCQYPN CRKVKGLFRH GINCKVRASG GCVLCKKMWY LLQLHARACK 1650
ESECHVPRCR DLKEHLRRLQ QQSDSRRRAA VMEMMRQRAA EVAGGSG 1697
Length:1,697
Mass (Da):190,045
Last modified:May 31, 2011 - v2
Checksum:i3B735C2DF863CDB0
GO
Isoform 2 (identifier: Q9C5X9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1661-1697: Missing.

Note: Incomplete sequence.

Show »
Length:1,660
Mass (Da):185,837
Checksum:i69BF7EDE6D8B6A13
GO

Sequence cautioni

The sequence AAC17068.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1661 – 169737Missing in isoform 2.
VSP_041112Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002986 Genomic DNA. Translation: AAC17068.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36191.1.
AF323954 mRNA. Translation: AAG60059.1.
PIRiT01055.
RefSeqiNP_565197.3. NM_106550.3. [Q9C5X9-1]
UniGeneiAt.21972.

Genome annotation databases

EnsemblPlantsiAT1G79000.1; AT1G79000.1; AT1G79000. [Q9C5X9-1]
AT1G79000.2; AT1G79000.2; AT1G79000.
GeneIDi844241.
KEGGiath:AT1G79000.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002986 Genomic DNA. Translation: AAC17068.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE36191.1 .
AF323954 mRNA. Translation: AAG60059.1 .
PIRi T01055.
RefSeqi NP_565197.3. NM_106550.3. [Q9C5X9-1 ]
UniGenei At.21972.

3D structure databases

ProteinModelPortali Q9C5X9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8059460.

Proteomic databases

PaxDbi Q9C5X9.
PRIDEi Q9C5X9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G79000.1 ; AT1G79000.1 ; AT1G79000 . [Q9C5X9-1 ]
AT1G79000.2 ; AT1G79000.2 ; AT1G79000 .
GeneIDi 844241.
KEGGi ath:AT1G79000.

Organism-specific databases

TAIRi AT1G79000.

Phylogenomic databases

eggNOGi NOG326839.
HOGENOMi HOG000242057.
InParanoidi Q9C5X9.
KOi K04498.

Enzyme and pathway databases

BioCyci ARA:AT1G79000-MONOMER.
ARA:GQT-2142-MONOMER.

Gene expression databases

ArrayExpressi Q9C5X9.
Genevestigatori Q9C5X9.

Family and domain databases

Gene3Di 1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
    Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
    Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-1660 (ISOFORM 2), MUTAGENESIS OF 1159-PHE--TYR-1161; 1279-TRP-TYR-1280 AND 1283-MET-LEU-1284, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, CATALYTIC ACTIVITY.
  4. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiHAC1_ARATH
AccessioniPrimary (citable) accession number: Q9C5X9
Secondary accession number(s): O64548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 31, 2011
Last modified: June 11, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi