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Protein

Histone acetyltransferase HAC1

Gene

HAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.1 Publication

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1279Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri629 – 709TAZ-type 1PROSITE-ProRule annotationAdd BLAST81
Zinc fingeri989 – 1066PHD-typeAdd BLAST78
Zinc fingeri1398 – 1445ZZ-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1518 – 1566ZZ-type 2PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri1579 – 1662TAZ-type 2PROSITE-ProRule annotationAdd BLAST84

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-3371568. Attenuation phase.
R-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC1 (EC:2.3.1.481 Publication)
Gene namesi
Name:HAC1
Synonyms:PCAT2
Ordered Locus Names:At1g79000
ORF Names:YUP8H12R.38, YUP8H12R_22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G79000.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1159 – 1161FAY → AAA: Abolishes acetyltransferase activity. 1 Publication3
Mutagenesisi1279 – 1280WY → AA: Abolishes acetyltransferase activity. 1 Publication2
Mutagenesisi1283 – 1284ML → AA: 3-fold decrease in acetyltransferase activity. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697401 – 1697Histone acetyltransferase HAC1Add BLAST1697

Proteomic databases

PaxDbiQ9C5X9.

PTM databases

iPTMnetiQ9C5X9.

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

ExpressionAtlasiQ9C5X9. baseline and differential.
GenevisibleiQ9C5X9. AT.

Interactioni

Protein-protein interaction databases

BioGridi29460. 3 interactors.
IntActiQ9C5X9. 11 interactors.
MINTiMINT-8059460.
STRINGi3702.AT1G79000.2.

Structurei

3D structure databases

ProteinModelPortaliQ9C5X9.
SMRiQ9C5X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1081 – 1517CBP/p300-type HATPROSITE-ProRule annotationAdd BLAST437

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1204 – 1206Acetyl-CoA bindingBy similarity3
Regioni1223 – 1224Acetyl-CoA bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi266 – 301Gln-richAdd BLAST36
Compositional biasi399 – 524Gln-richAdd BLAST126

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri629 – 709TAZ-type 1PROSITE-ProRule annotationAdd BLAST81
Zinc fingeri989 – 1066PHD-typeAdd BLAST78
Zinc fingeri1398 – 1445ZZ-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1518 – 1566ZZ-type 2PROSITE-ProRule annotationAdd BLAST49
Zinc fingeri1579 – 1662TAZ-type 2PROSITE-ProRule annotationAdd BLAST84

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRVA. Eukaryota.
ENOG410XPJ0. LUCA.
HOGENOMiHOG000242057.
InParanoidiQ9C5X9.
KOiK04498.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR031162. CBP_P300_HAT.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR035898. TAZ_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
PfamiView protein in Pfam
PF08214. HAT_KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
SMARTiView protein in SMART
SM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiView protein in PROSITE
PS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9C5X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVQAHMSGQ VSNQGTMSQQ NGNSQMQNLV GGGSAPATGA GLGPSRVSPV
60 70 80 90 100
DNDILKLRQA MRIRIFNILQ QKQPSPADEA SKAKYMDVAR RLEEGLFKIA
110 120 130 140 150
NTKEDYVNPS TLEPRLASLI KGRQLNNYNQ RHANSSSVGT MIPTPGLQHS
160 170 180 190 200
GGNPNLMITS SGDATMAGSN NITTSAMNTG NLLNSGGMLG GNLSNGYQHS
210 220 230 240 250
SSNFGLGSGG NMSSMSSQRN TGQMMPTPGF VNSSTNNNSN NGQSYLSVEA
260 270 280 290 300
SNNSGGFSTA PMMVPQTQQQ QLRQDIGGQN SRMLQNHGSQ MGVGLRPGMQ
310 320 330 340 350
QKLSNVSNSS INGGVGMNAK SVDSGTSYTN PIRNSQQAYD NLQRSGMQGD
360 370 380 390 400
GYGTNNSDPF GSGNLYGAVT SVGMMTNTQN ANTASFQAVS RTSSSLSHQQ
410 420 430 440 450
QQFQQQPNRF QQQPNQFHQQ QQQFLHQQQL KQQSQQQQRF ISHDAFGQNN
460 470 480 490 500
VASDMVTHVK HEPGMENPSE SIHSQTPEQF QLSQFQNQYQ NNAEDRHAGS
510 520 530 540 550
QILPVTSQSD MCTSVPQNSQ QIQQMLHPHS MASDSVNGFS NLSVGVKTES
560 570 580 590 600
GMRGHWQSQS QEHTQMSNSM SNERHIQEDF RQRMSGTDEA QPNNMSGGSI
610 620 630 640 650
IGQNRVSTTS ESLNPQNPTA TTCRNGNGNR DPRFKNQQKW LLFLRHARHC
660 670 680 690 700
KAPEGKCPDR NCVTVQKLWK HMDSCAAPQC SYPRCLPTKT LINHHRSCKE
710 720 730 740 750
PNCPVCIPVK AYLQQQANAR SLARLKNETD AARSVNGGGI SSDAVQTSAG
760 770 780 790 800
AKSCTSPGAD ISGHLQPSLK RLKVEQSSQP VDVETESCKS SVVSVTEAQS
810 820 830 840 850
SQYAERKDHK HSDVRAPSKY FEVKAEVSDF SVQTRPGFKD TKIGIAENIP
860 870 880 890 900
KQRPVSQPDK QDLSDVSPMQ ETTKVEKEPE SLKKENLAES TEHTSKSGKP
910 920 930 940 950
EIKGVSLTEL FTPEQVREHI RGLRQWVGQS KAKAEKNQAM EHSMSENSCQ
960 970 980 990 1000
LCAVEKLTFE PPPIYCTPCG ARIKRNAMYY TVGAGDTRHY FCIPCYNESR
1010 1020 1030 1040 1050
GDTILAEGTP MPKARLEKKK NDEETEEWWV QCDKCEAWQH QICALFNGRR
1060 1070 1080 1090 1100
NDGGQAEYTC PYCFIAEVEQ SKRKPLPQSA VLGAKDLPRT ILSDHIEQRL
1110 1120 1130 1140 1150
FKRLKQERTE RARAQGKSYD EIPTAESLVI RVVSSVDKKL EVKPRFLEIF
1160 1170 1180 1190 1200
REDSYPTEFA YKSKVVLLFQ KIEGVEVCLF GMYVQEFGSE CAFPNQRRVY
1210 1220 1230 1240 1250
LSYLDSVKYF RPEVRSYNGE ALRTFVYHEI LIGYLEYCKL RGFTSCYIWA
1260 1270 1280 1290 1300
CPPLKGEDYI LYCHPEIQKT PKSDKLREWY LAMLRKASKE GIVAETINLY
1310 1320 1330 1340 1350
DHFFMQTGEC RAKVTAARLP YFDGDYWPGA AEDLIYQMSQ EEDGRKGNKK
1360 1370 1380 1390 1400
GMLKKTITKR ALKASGQTDL SGNASKDLLL MHRLGETIHP MKEDFIMVHL
1410 1420 1430 1440 1450
QPSCTHCCIL MVSGNRWVCS QCKHFQICDK CYEAEQRRED RERHPVNFKD
1460 1470 1480 1490 1500
KHALYPVEIM DIPADTRDKD EILESEFFDT RQAFLSLCQG NHYQYDTLRR
1510 1520 1530 1540 1550
AKHSSMMVLY HLHNPTAPAF VTTCNACHLD IETGQGWRCE VCPDYDVCNA
1560 1570 1580 1590 1600
CFSRDGGVNH PHKLTNHPSL ADQNAQNKEA RQLRVLQLRK MLDLLVHASQ
1610 1620 1630 1640 1650
CRSAHCQYPN CRKVKGLFRH GINCKVRASG GCVLCKKMWY LLQLHARACK
1660 1670 1680 1690
ESECHVPRCR DLKEHLRRLQ QQSDSRRRAA VMEMMRQRAA EVAGGSG
Length:1,697
Mass (Da):190,045
Last modified:May 31, 2011 - v2
Checksum:i3B735C2DF863CDB0
GO
Isoform 2 (identifier: Q9C5X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1661-1697: Missing.

Note: Incomplete sequence.
Show »
Length:1,660
Mass (Da):185,837
Checksum:i69BF7EDE6D8B6A13
GO

Sequence cautioni

Q9C5X9: The sequence AAC17068 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0411121661 – 1697Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002986 Genomic DNA. Translation: AAC17068.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36191.1.
AF323954 mRNA. Translation: AAG60059.1.
PIRiT01055.
RefSeqiNP_565197.3. NM_106550.4. [Q9C5X9-1]
UniGeneiAt.21972.

Genome annotation databases

EnsemblPlantsiAT1G79000.1; AT1G79000.1; AT1G79000. [Q9C5X9-1]
GeneIDi844241.
GrameneiAT1G79000.1; AT1G79000.1; AT1G79000.
KEGGiath:AT1G79000.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHAC1_ARATH
AccessioniPrimary (citable) accession number: Q9C5X9
Secondary accession number(s): O64548
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 31, 2011
Last modified: October 25, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names