Q9C5X9 (HAC1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase HAC1
EC=2.3.1.48

Gene names

Name:	HAC1
Synonyms:	PCAT2
Ordered Locus Names:	At1g79000
ORF Names:	YUP8H12R.38, YUP8H12R_22

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	1697 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone]. Ref.3
Subcellular location	Nucleus Probable.
Tissue specificity	Rosette leaves, stems and flowers. Ref.3
Developmental stage	Expressed in young seedlings. Ref.3
Sequence similarities	Contains 1 PHD-type zinc finger. Contains 2 TAZ-type zinc fingers. Contains 2 ZZ-type zinc fingers.
Sequence caution	The sequence AAC17068.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Activator Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone acetylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC transcription cofactor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9C5X9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9C5X9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1661-1697: Missing.

Note: Incomplete sequence.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1697	1697	Histone acetyltransferase HAC1		PRO_0000269740
Regions
	Zinc finger	629 – 709	81	TAZ-type 1
	Zinc finger	989 – 1066	78	PHD-type
	Zinc finger	1398 – 1445	48	ZZ-type 1
	Zinc finger	1518 – 1566	49	ZZ-type 2
	Zinc finger	1579 – 1662	84	TAZ-type 2
	Compositional bias	266 – 301	36	Gln-rich
	Compositional bias	399 – 524	126	Gln-rich
Natural variations
	Alternative sequence	1661 – 1697	37	Missing in isoform 2.		VSP_041112
Experimental info
	Mutagenesis	1159 – 1161	3	FAY → AAA: Abolishes acetyltransferase activity.
	Mutagenesis	1279 – 1280	2	WY → AA: Abolishes acetyltransferase activity.
	Mutagenesis	1283 – 1284	2	ML → AA: 3-fold decrease in acetyltransferase activity.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 31, 2011. Version 2. Checksum: 3B735C2DF863CDB0	FASTA	1,697	190,045
	10 20 30 40 50 60 MNVQAHMSGQ VSNQGTMSQQ NGNSQMQNLV GGGSAPATGA GLGPSRVSPV DNDILKLRQA 70 80 90 100 110 120 MRIRIFNILQ QKQPSPADEA SKAKYMDVAR RLEEGLFKIA NTKEDYVNPS TLEPRLASLI 130 140 150 160 170 180 KGRQLNNYNQ RHANSSSVGT MIPTPGLQHS GGNPNLMITS SGDATMAGSN NITTSAMNTG 190 200 210 220 230 240 NLLNSGGMLG GNLSNGYQHS SSNFGLGSGG NMSSMSSQRN TGQMMPTPGF VNSSTNNNSN 250 260 270 280 290 300 NGQSYLSVEA SNNSGGFSTA PMMVPQTQQQ QLRQDIGGQN SRMLQNHGSQ MGVGLRPGMQ 310 320 330 340 350 360 QKLSNVSNSS INGGVGMNAK SVDSGTSYTN PIRNSQQAYD NLQRSGMQGD GYGTNNSDPF 370 380 390 400 410 420 GSGNLYGAVT SVGMMTNTQN ANTASFQAVS RTSSSLSHQQ QQFQQQPNRF QQQPNQFHQQ 430 440 450 460 470 480 QQQFLHQQQL KQQSQQQQRF ISHDAFGQNN VASDMVTHVK HEPGMENPSE SIHSQTPEQF 490 500 510 520 530 540 QLSQFQNQYQ NNAEDRHAGS QILPVTSQSD MCTSVPQNSQ QIQQMLHPHS MASDSVNGFS 550 560 570 580 590 600 NLSVGVKTES GMRGHWQSQS QEHTQMSNSM SNERHIQEDF RQRMSGTDEA QPNNMSGGSI 610 620 630 640 650 660 IGQNRVSTTS ESLNPQNPTA TTCRNGNGNR DPRFKNQQKW LLFLRHARHC KAPEGKCPDR 670 680 690 700 710 720 NCVTVQKLWK HMDSCAAPQC SYPRCLPTKT LINHHRSCKE PNCPVCIPVK AYLQQQANAR 730 740 750 760 770 780 SLARLKNETD AARSVNGGGI SSDAVQTSAG AKSCTSPGAD ISGHLQPSLK RLKVEQSSQP 790 800 810 820 830 840 VDVETESCKS SVVSVTEAQS SQYAERKDHK HSDVRAPSKY FEVKAEVSDF SVQTRPGFKD 850 860 870 880 890 900 TKIGIAENIP KQRPVSQPDK QDLSDVSPMQ ETTKVEKEPE SLKKENLAES TEHTSKSGKP 910 920 930 940 950 960 EIKGVSLTEL FTPEQVREHI RGLRQWVGQS KAKAEKNQAM EHSMSENSCQ LCAVEKLTFE 970 980 990 1000 1010 1020 PPPIYCTPCG ARIKRNAMYY TVGAGDTRHY FCIPCYNESR GDTILAEGTP MPKARLEKKK 1030 1040 1050 1060 1070 1080 NDEETEEWWV QCDKCEAWQH QICALFNGRR NDGGQAEYTC PYCFIAEVEQ SKRKPLPQSA 1090 1100 1110 1120 1130 1140 VLGAKDLPRT ILSDHIEQRL FKRLKQERTE RARAQGKSYD EIPTAESLVI RVVSSVDKKL 1150 1160 1170 1180 1190 1200 EVKPRFLEIF REDSYPTEFA YKSKVVLLFQ KIEGVEVCLF GMYVQEFGSE CAFPNQRRVY 1210 1220 1230 1240 1250 1260 LSYLDSVKYF RPEVRSYNGE ALRTFVYHEI LIGYLEYCKL RGFTSCYIWA CPPLKGEDYI 1270 1280 1290 1300 1310 1320 LYCHPEIQKT PKSDKLREWY LAMLRKASKE GIVAETINLY DHFFMQTGEC RAKVTAARLP 1330 1340 1350 1360 1370 1380 YFDGDYWPGA AEDLIYQMSQ EEDGRKGNKK GMLKKTITKR ALKASGQTDL SGNASKDLLL 1390 1400 1410 1420 1430 1440 MHRLGETIHP MKEDFIMVHL QPSCTHCCIL MVSGNRWVCS QCKHFQICDK CYEAEQRRED 1450 1460 1470 1480 1490 1500 RERHPVNFKD KHALYPVEIM DIPADTRDKD EILESEFFDT RQAFLSLCQG NHYQYDTLRR 1510 1520 1530 1540 1550 1560 AKHSSMMVLY HLHNPTAPAF VTTCNACHLD IETGQGWRCE VCPDYDVCNA CFSRDGGVNH 1570 1580 1590 1600 1610 1620 PHKLTNHPSL ADQNAQNKEA RQLRVLQLRK MLDLLVHASQ CRSAHCQYPN CRKVKGLFRH 1630 1640 1650 1660 1670 1680 GINCKVRASG GCVLCKKMWY LLQLHARACK ESECHVPRCR DLKEHLRRLQ QQSDSRRRAA 1690 VMEMMRQRAA EVAGGSG
	Isoform 2 [UniParc]. Checksum: 69BF7EDE6D8B6A13	FASTA	1,660	185,837
	10 20 30 40 50 60 MNVQAHMSGQ VSNQGTMSQQ NGNSQMQNLV GGGSAPATGA GLGPSRVSPV DNDILKLRQA 70 80 90 100 110 120 MRIRIFNILQ QKQPSPADEA SKAKYMDVAR RLEEGLFKIA NTKEDYVNPS TLEPRLASLI 130 140 150 160 170 180 KGRQLNNYNQ RHANSSSVGT MIPTPGLQHS GGNPNLMITS SGDATMAGSN NITTSAMNTG 190 200 210 220 230 240 NLLNSGGMLG GNLSNGYQHS SSNFGLGSGG NMSSMSSQRN TGQMMPTPGF VNSSTNNNSN 250 260 270 280 290 300 NGQSYLSVEA SNNSGGFSTA PMMVPQTQQQ QLRQDIGGQN SRMLQNHGSQ MGVGLRPGMQ 310 320 330 340 350 360 QKLSNVSNSS INGGVGMNAK SVDSGTSYTN PIRNSQQAYD NLQRSGMQGD GYGTNNSDPF 370 380 390 400 410 420 GSGNLYGAVT SVGMMTNTQN ANTASFQAVS RTSSSLSHQQ QQFQQQPNRF QQQPNQFHQQ 430 440 450 460 470 480 QQQFLHQQQL KQQSQQQQRF ISHDAFGQNN VASDMVTHVK HEPGMENPSE SIHSQTPEQF 490 500 510 520 530 540 QLSQFQNQYQ NNAEDRHAGS QILPVTSQSD MCTSVPQNSQ QIQQMLHPHS MASDSVNGFS 550 560 570 580 590 600 NLSVGVKTES GMRGHWQSQS QEHTQMSNSM SNERHIQEDF RQRMSGTDEA QPNNMSGGSI 610 620 630 640 650 660 IGQNRVSTTS ESLNPQNPTA TTCRNGNGNR DPRFKNQQKW LLFLRHARHC KAPEGKCPDR 670 680 690 700 710 720 NCVTVQKLWK HMDSCAAPQC SYPRCLPTKT LINHHRSCKE PNCPVCIPVK AYLQQQANAR 730 740 750 760 770 780 SLARLKNETD AARSVNGGGI SSDAVQTSAG AKSCTSPGAD ISGHLQPSLK RLKVEQSSQP 790 800 810 820 830 840 VDVETESCKS SVVSVTEAQS SQYAERKDHK HSDVRAPSKY FEVKAEVSDF SVQTRPGFKD 850 860 870 880 890 900 TKIGIAENIP KQRPVSQPDK QDLSDVSPMQ ETTKVEKEPE SLKKENLAES TEHTSKSGKP 910 920 930 940 950 960 EIKGVSLTEL FTPEQVREHI RGLRQWVGQS KAKAEKNQAM EHSMSENSCQ LCAVEKLTFE 970 980 990 1000 1010 1020 PPPIYCTPCG ARIKRNAMYY TVGAGDTRHY FCIPCYNESR GDTILAEGTP MPKARLEKKK 1030 1040 1050 1060 1070 1080 NDEETEEWWV QCDKCEAWQH QICALFNGRR NDGGQAEYTC PYCFIAEVEQ SKRKPLPQSA 1090 1100 1110 1120 1130 1140 VLGAKDLPRT ILSDHIEQRL FKRLKQERTE RARAQGKSYD EIPTAESLVI RVVSSVDKKL 1150 1160 1170 1180 1190 1200 EVKPRFLEIF REDSYPTEFA YKSKVVLLFQ KIEGVEVCLF GMYVQEFGSE CAFPNQRRVY 1210 1220 1230 1240 1250 1260 LSYLDSVKYF RPEVRSYNGE ALRTFVYHEI LIGYLEYCKL RGFTSCYIWA CPPLKGEDYI 1270 1280 1290 1300 1310 1320 LYCHPEIQKT PKSDKLREWY LAMLRKASKE GIVAETINLY DHFFMQTGEC RAKVTAARLP 1330 1340 1350 1360 1370 1380 YFDGDYWPGA AEDLIYQMSQ EEDGRKGNKK GMLKKTITKR ALKASGQTDL SGNASKDLLL 1390 1400 1410 1420 1430 1440 MHRLGETIHP MKEDFIMVHL QPSCTHCCIL MVSGNRWVCS QCKHFQICDK CYEAEQRRED 1450 1460 1470 1480 1490 1500 RERHPVNFKD KHALYPVEIM DIPADTRDKD EILESEFFDT RQAFLSLCQG NHYQYDTLRR 1510 1520 1530 1540 1550 1560 AKHSSMMVLY HLHNPTAPAF VTTCNACHLD IETGQGWRCE VCPDYDVCNA CFSRDGGVNH 1570 1580 1590 1600 1610 1620 PHKLTNHPSL ADQNAQNKEA RQLRVLQLRK MLDLLVHASQ CRSAHCQYPN CRKVKGLFRH 1630 1640 1650 1660 GINCKVRASG GCVLCKKMWY LLQLHARACK ESECHVPRCR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins." Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R. Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-1660 (ISOFORM 2), MUTAGENESIS OF 1159-PHE--TYR-1161; 1279-TRP-TYR-1280 AND 1283-MET-LEU-1284, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, CATALYTIC ACTIVITY.
[4]	"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes." Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A. Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002986 Genomic DNA. Translation: AAC17068.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE36191.1. AF323954 mRNA. Translation: AAG60059.1.
IPI	IPI00537495. IPI01018437.
PIR	T01055.
RefSeq	NP_565197.3. NM_106550.3.
UniGene	At.21972.
3D structure databases
HSSP	HSSP built from PDB template 1TOT based on UniProtKB P45481.
ModBase	Search...
Proteomic databases
PaxDb	Q9C5X9.
PRIDE	Q9C5X9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G79000.1; AT1G79000.1; AT1G79000.
GeneID	844241.
KEGG	ath:AT1G79000.
Organism-specific databases
TAIR	At1g79000.
Phylogenomic databases
eggNOG	NOG326839.
HOGENOM	HOG000242057.
InParanoid	Q9C5X9.
KO	K04498.
Gene expression databases
ArrayExpress	Q9C5X9.
Genevestigator	Q9C5X9.
Family and domain databases
Gene3D	1.20.1020.10. 2 hits. 3.30.40.10. 1 hit.
InterPro	IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR013083. Znf_RING/FYVE/PHD. IPR000197. Znf_TAZ. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF08214. KAT11. 1 hit. PF02135. zf-TAZ. 2 hits. PF00569. ZZ. 1 hit. [Graphical view]
SMART	SM00249. PHD. 1 hit. SM00551. ZnF_TAZ. 2 hits. SM00291. ZnF_ZZ. 2 hits. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit. SSF57933. TAZ_finger. 2 hits.
PROSITE	PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. False negative. PS50134. ZF_TAZ. 2 hits. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAC1_ARATH

Accession

Primary (citable) accession number: Q9C5X9
Secondary accession number(s): O64548

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	May 31, 2011
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program