Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9C5X9 (HAC1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase HAC1

EC=2.3.1.48
Gene names
Name:HAC1
Synonyms:PCAT2
Ordered Locus Names:At1g79000
ORF Names:YUP8H12R.38, YUP8H12R_22
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length1697 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone]. Ref.3

Subcellular location

Nucleus Probable.

Tissue specificity

Rosette leaves, stems and flowers. Ref.3

Developmental stage

Expressed in young seedlings. Ref.3

Sequence similarities

Contains 1 PHD-type zinc finger.

Contains 2 TAZ-type zinc fingers.

Contains 2 ZZ-type zinc fingers.

Sequence caution

The sequence AAC17068.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9C5X9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9C5X9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1661-1697: Missing.
Note: Incomplete sequence.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16971697Histone acetyltransferase HAC1
PRO_0000269740

Regions

Zinc finger629 – 70981TAZ-type 1
Zinc finger989 – 106678PHD-type
Zinc finger1398 – 144548ZZ-type 1
Zinc finger1518 – 156649ZZ-type 2
Zinc finger1579 – 166284TAZ-type 2
Compositional bias266 – 30136Gln-rich
Compositional bias399 – 524126Gln-rich

Natural variations

Alternative sequence1661 – 169737Missing in isoform 2.
VSP_041112

Experimental info

Mutagenesis1159 – 11613FAY → AAA: Abolishes acetyltransferase activity.
Mutagenesis1279 – 12802WY → AA: Abolishes acetyltransferase activity.
Mutagenesis1283 – 12842ML → AA: 3-fold decrease in acetyltransferase activity.

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 31, 2011. Version 2.
Checksum: 3B735C2DF863CDB0

FASTA1,697190,045
        10         20         30         40         50         60 
MNVQAHMSGQ VSNQGTMSQQ NGNSQMQNLV GGGSAPATGA GLGPSRVSPV DNDILKLRQA 

        70         80         90        100        110        120 
MRIRIFNILQ QKQPSPADEA SKAKYMDVAR RLEEGLFKIA NTKEDYVNPS TLEPRLASLI 

       130        140        150        160        170        180 
KGRQLNNYNQ RHANSSSVGT MIPTPGLQHS GGNPNLMITS SGDATMAGSN NITTSAMNTG 

       190        200        210        220        230        240 
NLLNSGGMLG GNLSNGYQHS SSNFGLGSGG NMSSMSSQRN TGQMMPTPGF VNSSTNNNSN 

       250        260        270        280        290        300 
NGQSYLSVEA SNNSGGFSTA PMMVPQTQQQ QLRQDIGGQN SRMLQNHGSQ MGVGLRPGMQ 

       310        320        330        340        350        360 
QKLSNVSNSS INGGVGMNAK SVDSGTSYTN PIRNSQQAYD NLQRSGMQGD GYGTNNSDPF 

       370        380        390        400        410        420 
GSGNLYGAVT SVGMMTNTQN ANTASFQAVS RTSSSLSHQQ QQFQQQPNRF QQQPNQFHQQ 

       430        440        450        460        470        480 
QQQFLHQQQL KQQSQQQQRF ISHDAFGQNN VASDMVTHVK HEPGMENPSE SIHSQTPEQF 

       490        500        510        520        530        540 
QLSQFQNQYQ NNAEDRHAGS QILPVTSQSD MCTSVPQNSQ QIQQMLHPHS MASDSVNGFS 

       550        560        570        580        590        600 
NLSVGVKTES GMRGHWQSQS QEHTQMSNSM SNERHIQEDF RQRMSGTDEA QPNNMSGGSI 

       610        620        630        640        650        660 
IGQNRVSTTS ESLNPQNPTA TTCRNGNGNR DPRFKNQQKW LLFLRHARHC KAPEGKCPDR 

       670        680        690        700        710        720 
NCVTVQKLWK HMDSCAAPQC SYPRCLPTKT LINHHRSCKE PNCPVCIPVK AYLQQQANAR 

       730        740        750        760        770        780 
SLARLKNETD AARSVNGGGI SSDAVQTSAG AKSCTSPGAD ISGHLQPSLK RLKVEQSSQP 

       790        800        810        820        830        840 
VDVETESCKS SVVSVTEAQS SQYAERKDHK HSDVRAPSKY FEVKAEVSDF SVQTRPGFKD 

       850        860        870        880        890        900 
TKIGIAENIP KQRPVSQPDK QDLSDVSPMQ ETTKVEKEPE SLKKENLAES TEHTSKSGKP 

       910        920        930        940        950        960 
EIKGVSLTEL FTPEQVREHI RGLRQWVGQS KAKAEKNQAM EHSMSENSCQ LCAVEKLTFE 

       970        980        990       1000       1010       1020 
PPPIYCTPCG ARIKRNAMYY TVGAGDTRHY FCIPCYNESR GDTILAEGTP MPKARLEKKK 

      1030       1040       1050       1060       1070       1080 
NDEETEEWWV QCDKCEAWQH QICALFNGRR NDGGQAEYTC PYCFIAEVEQ SKRKPLPQSA 

      1090       1100       1110       1120       1130       1140 
VLGAKDLPRT ILSDHIEQRL FKRLKQERTE RARAQGKSYD EIPTAESLVI RVVSSVDKKL 

      1150       1160       1170       1180       1190       1200 
EVKPRFLEIF REDSYPTEFA YKSKVVLLFQ KIEGVEVCLF GMYVQEFGSE CAFPNQRRVY 

      1210       1220       1230       1240       1250       1260 
LSYLDSVKYF RPEVRSYNGE ALRTFVYHEI LIGYLEYCKL RGFTSCYIWA CPPLKGEDYI 

      1270       1280       1290       1300       1310       1320 
LYCHPEIQKT PKSDKLREWY LAMLRKASKE GIVAETINLY DHFFMQTGEC RAKVTAARLP 

      1330       1340       1350       1360       1370       1380 
YFDGDYWPGA AEDLIYQMSQ EEDGRKGNKK GMLKKTITKR ALKASGQTDL SGNASKDLLL 

      1390       1400       1410       1420       1430       1440 
MHRLGETIHP MKEDFIMVHL QPSCTHCCIL MVSGNRWVCS QCKHFQICDK CYEAEQRRED 

      1450       1460       1470       1480       1490       1500 
RERHPVNFKD KHALYPVEIM DIPADTRDKD EILESEFFDT RQAFLSLCQG NHYQYDTLRR 

      1510       1520       1530       1540       1550       1560 
AKHSSMMVLY HLHNPTAPAF VTTCNACHLD IETGQGWRCE VCPDYDVCNA CFSRDGGVNH 

      1570       1580       1590       1600       1610       1620 
PHKLTNHPSL ADQNAQNKEA RQLRVLQLRK MLDLLVHASQ CRSAHCQYPN CRKVKGLFRH 

      1630       1640       1650       1660       1670       1680 
GINCKVRASG GCVLCKKMWY LLQLHARACK ESECHVPRCR DLKEHLRRLQ QQSDSRRRAA 

      1690 
VMEMMRQRAA EVAGGSG 

« Hide

Isoform 2 [UniParc].

Checksum: 69BF7EDE6D8B6A13
Show »

FASTA1,660185,837

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-1660 (ISOFORM 2), MUTAGENESIS OF 1159-PHE--TYR-1161; 1279-TRP-TYR-1280 AND 1283-MET-LEU-1284, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, CATALYTIC ACTIVITY.
[4]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC002986 Genomic DNA. Translation: AAC17068.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36191.1.
AF323954 mRNA. Translation: AAG60059.1.
PIRT01055.
RefSeqNP_565197.3. NM_106550.3.
UniGeneAt.21972.

3D structure databases

ProteinModelPortalQ9C5X9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-8059460.

Proteomic databases

PaxDbQ9C5X9.
PRIDEQ9C5X9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G79000.1; AT1G79000.1; AT1G79000. [Q9C5X9-1]
GeneID844241.
KEGGath:AT1G79000.

Organism-specific databases

TAIRAT1G79000.

Phylogenomic databases

eggNOGNOG326839.
HOGENOMHOG000242057.
InParanoidQ9C5X9.
KOK04498.

Enzyme and pathway databases

BioCycARA:AT1G79000-MONOMER.
ARA:GQT-2142-MONOMER.

Gene expression databases

ArrayExpressQ9C5X9.
GenevestigatorQ9C5X9.

Family and domain databases

Gene3D1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHAC1_ARATH
AccessionPrimary (citable) accession number: Q9C5X9
Secondary accession number(s): O64548
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 31, 2011
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names